Abstract: A recombinant baculovirus for use as an insect control agent having a genome which comprises a polyhedrin gene and a heterologous gene, which expresses an insecticidal protein, wherein the polyhedrin gene and the heterologous gene are not under the control of the same promoter, and are located on the genome such that viral progeny produced by a recombination event with wild-type baculovirus which are viable do not retain expression of both the polyhedrin gene and the heterologous gene.
Abstract: A dye of Formula (1) and salts thereof: ##STR1## in which R is H, --NHC.sub.1-4 -alkylN(C.sub.1-4 -alkyl).sub.2 or ##STR2## R.sub.1 and R.sub.2 each independently is H, optionally substituted C.sub.1-4 -alkyl or optionally substituted aryl;R.sub.3 is C.sub.1-4 -alkyl;R.sub.4 is C.sub.1-4 -alkyl or OC.sub.1-4 -alkyl;R.sub.5 is H;R.sub.6 is COOH; andn is 1, 2 or 3.The dyes are useful for preparing ink jet printer inks.
Type:
Grant
Filed:
October 9, 1997
Date of Patent:
March 16, 1999
Assignee:
Zeneca Limited
Inventors:
Peter Gregory, Prahalad Manibhai Mistry, Roy Bradbury, Paul Wight
Abstract: A medical syringe comprises a cylindrical barrel 1 having therein a plunger 4 which can be axially driven by a plunger rod 3. The plunger rod 3 passes through an aperture in the centre of a finger grip 2 having two finger grip projections 2b at opposite sides thereof. A data carrier means in the form of an electrically or magnetically operable device 2c is mounted near the end of one of the two finger grip projections 2b, with preferably a device 2c mounted near the end of each finger grip projection 2b. The device 2c carries data relating to the medicament contained or to be contained within the syringe, and can be read by a suitably adapted syringe pump when the syringe is mounted thereon to be driven by the syringe pump.
Abstract: A toner resin composition comprising a toner resin and an aromatic sulphonic acid salt of a guanidine such as the bis-diphenylguanidine salt of naphthalene-1,5-disulphonic acid. The diphenyl guanidine salts are novel.
Abstract: A bisazo dye of Formula (1) and salts thereof: ##STR1## in which R is H or ##STR2## R.sub.1 and R.sub.2 each independently is H, optionally substituted C.sub.1-4 -alkyl or optionally substituted aryl;R.sub.3 and R.sub.5 together with the carbon atoms to which they are attached form a 5- or 6-membered carbocyclic ring which is optionally substituted by SO.sub.3 H;R.sub.4 is H;R.sub.6 is COOH;n is 1, 2 or 3; andp is 1, 2, 3 or 4.The dyes are useful for ink jet printing.
Type:
Grant
Filed:
October 9, 1997
Date of Patent:
March 16, 1999
Assignee:
Zeneca Limited
Inventors:
Peter Gregory, Prahalad Manibhai Mistry, Roy Bradbury, Paul Wight
Abstract: There is provided a composite article which comprises a first substrate comprising a body of metal containing aluminium or galvanised steel, a second substrate and, interposed between said first and second substrates whereby to provide adhesive bonding between said substrates, an adhesive and 2.sup.1,3,4.sup.1,5,7-pentahydroxyflavone with the proviso that when either substrate is etched or anodised aluminium, the pentahydroxyflavone is not present thereon as a primer coat.
Type:
Grant
Filed:
July 11, 1996
Date of Patent:
March 9, 1999
Assignee:
Zeneca Limited
Inventors:
Michael Ellwood, Stephen William Leeming
Abstract: A method for the protection of a medium by susceptible to microbial attack by the treatment of the medium with an oxaborale or a salt of an oxaborale.
Type:
Grant
Filed:
December 9, 1996
Date of Patent:
March 9, 1999
Assignee:
Zeneca Limited
Inventors:
Peter William Austin, Christopher Juan Kneale, Patrick Jelf Crowley, John Martin Clough
Abstract: The invention concerns pyrimidine derivatives of formula wherein m is 1, 2 or 3; each R.sup.1 is independently hydrogen, hydroxy, (un)substituted amino, nitro, halogeno, cyano, carboxy, (un)substituted carbamoyl, ureido, (1-4C) alkoxycarbonyl, (un)substituted (1-4C)alkyl, (un)substituted (1-4C)alkoxy, (1-3C)alkylenedioxy, (1-4C)alkylthio, (1-4C)alkylsulphinyl, (1-4C)alkyl-sulphonyl, (2-4C)alkanoyloxy; n is 1, 2 or 3; and each R.sup.2 is independently hydrogen, hydroxy, halogeno, trifluoromethyl, trifluoromethoxy, amino, nitro, cyano, (1-4C)alkyl, (1-4C)alkoxy, (1-4C)alkylamino, di-?(1-4C)alkyl!amino, (1-4C)alkylthio, (1-4C)alkylsulphinyl, (1-4C)alkylsulphonyl, (2-4C)alkanoylamino, (2-4C)alkanoyl or (1-3C)alkylenedioxy; or a pharmaceutically-acceptable salt thereof; processes for their preparation; pharmaceutical compositions containing them; and the use of the receptor tyrosine kinase inhibitory properties of the compounds in the treatment of cell-proliferation diseases.
Abstract: Ink compositions comprising an aqueous medium containing:(1) at least one water-soluble dye;(2) at least one cyclic ester or amide of the formula: ##STR1## wherein m is a whole number from 3 to 5 and X represents --O-- or --N(R)-- in which R represents hydrogen, alkyl or substituted alkyl;(3) at least one hydroxy compound selected from polyhydroxy compounds having at least four hydroxy groups, optionally substituted cycloalkanols, cyclohexane dimethanol, benzyl alcohol, benzene dimethanol, phenol and polyhydroxybenzenes, and(4) at least one water-soluble organic solvent selected from alkanediols, alkanetriols, ether glycols and thioether glycols and suitable for use in inkjet printing processes for coloration of substrates such as paper or overhead projector slides.
Type:
Grant
Filed:
October 29, 1997
Date of Patent:
March 2, 1999
Assignee:
Zeneca Limited
Inventors:
Janet Gunn, Mark Holbrook, Aidan Joseph Lavery
Abstract: The present invention provides novel methods of treating pain comprising administering to a mammal in need of such treatment an effective analgesic amount of a peptide having the amino acid sequence of SEQ ID. NO.: 1 or SEQ ID NO: 2. The invention further provides a purified peptide having the amino acid sequence of SEQ ID NO: 1. The peptides of SEQ ID NO.: 1 and SEQ ID NO.: 2 can also be used in methods for identifying compounds having analgesia-inducing activity.
Abstract: The present invention relates, in general, to a tumor suppressor and, in particular, to the mannose 6-phosphate/insulin-like growth factor-II (M6P/IGF-II) receptor and to diagnostic and therapeutic approaches based on same.
Type:
Grant
Filed:
November 15, 1996
Date of Patent:
February 23, 1999
Assignees:
Duke University, Zeneca Limited
Inventors:
Randy L. Jirtle, Angus T. DeSouza, Gerald R. Hankins
Abstract: A process for the preparation of 4,4,4-trichlorobutan-1-ol which comprises reacting allyl alcohol with chloroform in the presence of a radical initiator. Preferably the allyl alcohol is added incrementally to the chloroform over the period of the reaction.
Abstract: Compounds of the formula: ##STR1## wherein R is CH.sub.2 X or CHX.sub.2 and X is chloro or bromo and R.sup.1 is chloro, bromo or nitro which are useful as intermediates for preparing herbicidal 2-(2'-substituted)-4'-(alkylsulfonyl)benzoyl-1,3-cyclohexanedione compounds.
Abstract: A composition of a water-soluble bis-azo dye of the Formula (1) and an oxidising agent. ##STR1## wherein A is optionally substituted phenyl or optionally substituted naphthyl;B is optionally substituted phenylene or optionally substituted naphthylene;R.sup.1 is H or sulpho;R.sup.2 is H, optionally substituted alkyl, optionally substituted aryl or optionally substituted acyl;R.sup.3 is H, optionally substituted aryl, optionally substituted alkyl or a group, -D-E,D is optionally substituted C.sub.2-6 -alkylene; andE is a group of the Formula (1a): ##STR2## R.sup.4 & R.sup.5 each independently is H or optionally substituted alkyl; andR.sup.6 is H, optionally substituted alkyl, optionally substituted aryl or optionally substituted acyl.
Type:
Grant
Filed:
January 8, 1998
Date of Patent:
February 9, 1999
Assignee:
Zeneca Limited
Inventors:
Peter Gregory, Ronald Wynford Kenyon, Paul Wight
Abstract: The synthesis of lignin by plants, particularly cereal and forage crops, is modified by genetic transformation with a construct which includes a DNA sequence which modifies the activity of the enzyme cinnamyl coenzyme A reductase (CCR). Sequence-ID-1 is the CCR sequence from Zea mays.
Abstract: The chemically-inducible 27 kD subunit of the enzyme glutathione-S-transferase, isoform II (GST-II-27) and sequences encoding it are provided. In particular, a genomic DNA sequence encoding the gene promoter for the GST-II-27 subunit is provided. Then linked to an exogenous gene and introduced into a plant by transformation, and GST-II-27 promoter provides a means for the external regulation of expression of that exogenous gene. Transformation with DNA encoding glutathione-S-transferase polypeptides produces herbicide resistance transgenic plants.
Type:
Grant
Filed:
June 17, 1996
Date of Patent:
February 2, 1999
Assignee:
Zeneca Limited
Inventors:
Ian George Bridges, Simon William Jonathan Bright, Andrew James Greenland, David Charles Holt, Ian Jepson, Wolfgang Walter Schuch
Abstract: A dye of Formula (1): ##STR1## wherein: D is a group of Formula (2): ##STR2## or a group of Formula (3): ##STR3## or a group of Formula (4): ##STR4## The variables are defined in the disclosures. The dyes and dye mixtures produce blue to green shades on synthetic textile materials such as polyester which have good build up and good light- and wet-fastness.
Type:
Grant
Filed:
June 19, 1997
Date of Patent:
February 2, 1999
Assignee:
Zeneca Limited
Inventors:
Denise Cavanagh, Mark Robert James, Barry Huston Meyrick, Paul Wight
Abstract: The invention concerns quinazoline derivatives of the formula I ##STR1## wherein X.sup.1 is a direct link or a group such as CO, C(R.sup.2).sub.2 and CH(OR.sup.2);wherein Q.sup.1 is phenyl, naphthyl or a 5- or 6-membered heteroaryl moiety and Q.sup.1 optionally bears up to 3 substituents;wherein m is 1 or 2 and each R.sup.1 may be a group such as hydrogen, halogeno and trifluoromethyl; andwherein Q.sup.2 may be phenyl or a 9- or 10-membered bicyclic heterocyclic moiety and Q.sup.2 optionally bears up to 3 substituents;or a pharmaceutically-acceptable salt thereof;processes for their preparation, pharmaceutical compositions containing them and the use of their receptor tyrosine kinase inhibitory properties in the treatment of proliferative disease such as cancer.
Abstract: Compounds of formula I, and their pharmaceutically acceptable salts, ##STR1## in which R.sup.1 and R.sup.2 are hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, phenylalkyl or alkenyl; or NR.sup.1 R.sup.2 is a heterocyclic group; A is trimethylene optionally substituted by alkyl and the phenyl ring is optionally substituted by substituents such as halogeno, alkenyl, amino, cyano, ureido, alkyl, carbamoylalkyl, alkanoylamino, alkoxycarbonyl, N-alkyl-alkanoylamino, alkanoyl and amines thereof; are inhibitors of squalene synthese and hence useful in treating diseases in which a lowering of cholesterol is desirable. As well as the use of these compounds in medicine, novel compounds, processes for their preparation and pharmaceutical compositions are also referred to.
Type:
Grant
Filed:
May 19, 1994
Date of Patent:
February 2, 1999
Assignee:
Zeneca Limited
Inventors:
George Robert Brown, Murdoch Allan Eakin, Peter John Harrison, deceased, Keith Blakeney Mallion
Abstract: A method for the recovery of a metal from an organic complex thereof, said method comprising treating the complex with a weakly acid aqueous solution of an alkali metal or alkaline earth metal chloride having a chloride content of at least 4 molar whereby said complex is decomposed and metal ions are transferred to the aqueous solution.