Abstract: A lyophilizate, method of preparation, and use of the lyophilizate for gonad protection is described. The lyophilizate comprises cetrorelix dissolved in 30% (v/v) acetic acid, transferred to water, and freeze-dried.
Type:
Grant
Filed:
May 24, 2002
Date of Patent:
March 15, 2005
Assignee:
Zentaris GmbH
Inventors:
Jürgen Engel, Burkhard Wichert, Dieter Sauerbier, Thomas Reissmann
Abstract: The present invention is directed in part towards methods of modulating the function of serine/threonine protein kinases with azabenzimidazole-based compounds. The methods incorporate cells that express a serine/threonine protein kinase, such as RAF. In addition, the invention describes methods of preventing and treating serine/threonine protein kinase-related abnormal conditions in organisms with a compound identified by the invention. Furthermore, the invention pertains to azabenzimidazole compounds and pharmaceutical compositions comprising these compounds.
Type:
Grant
Filed:
November 15, 2002
Date of Patent:
February 15, 2005
Assignee:
Zentaris GmbH
Inventors:
Gerald McMahon, Heinz Weinberger, Bernhard Kutscher, Harald App
Abstract: A novel lyophilizate and method of preparation as well as the use of the lyophilizate to treat female infertility and for gonad protection. Cetrorelix is dissolved in acetic acid 30% v/v, the solution is transferred to water and freeze dried.
Type:
Grant
Filed:
June 6, 1995
Date of Patent:
December 7, 2004
Assignee:
Zentaris GmbH
Inventors:
Jürgen Engel, Burkhard Wichert, Dieter Sauerbier, Thomas Reissmann
Abstract: A method for producing peptide salts, including reacting an acid addition salt of a basic starting peptide in the presence of a diluent in a mixed bed ion exchanger, with a mixture of an acid and a basic ion exchanger during the formation of a free basic peptide, and then separating the ion exchanger and then the free basic peptide, with an inorganic or organic acid, and then forming the desired acid addition salt of the peptide, and removing the diluent.
Type:
Grant
Filed:
August 24, 2001
Date of Patent:
August 24, 2004
Assignee:
Zentaris GmbH
Inventors:
Michael Damm, Waldemar Salonek, Jürgen Engel, Horst Bauer, Gabriele Stach