Abstract: N-[3-(3-Dimethylamino-acryloyl)-phenyl]-N-ethyl-acetamide is reacted with 5-amino-1H-pyrazol-4-carbonitrile in a medium comprising a solution of hydrochloric or hydrobromic acid in a C1-C5 alcohol, or in a C4-C6 aliphatic or cyclic ether, or in a C2-C5 alkoxyalcohol, or in a 5- to 6-membered aromatic heterocyclic solvent, containing 1-2 oxygen atoms, or in mixtures thereof with water, thus forming N-(3-(3-cyanopyrazolo[1,5-?]pyrimidin-7-yl)phenyl)-N-ethylacetamide (zaleplon) of formula I.
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