Patents Assigned to Zenyth Operations Pty Ltd.
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Patent number: 9085628Abstract: Binding members for alpha chain of receptor for granulocyte macrophage colony stimulating factor (GM-CSFR?), especially antibody molecules. Use of the binding members in treating inflammatory and autoimmune diseases, e.g. rheumatoid arthritis, asthma, allergic response, multiple sclerosis, myeloid leukaemia and atherosclerosis.Type: GrantFiled: July 12, 2013Date of Patent: July 21, 2015Assignees: MedImmune Limited, Zenyth Operations Pty. Ltd.Inventors: Emma Suzanne Cohen, Ralph Raymond Minter, Paula Rosamund Harrison, Matthew Alexander Sleeman, Andrew Donald Nash, Louis Jerry Fabri
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Publication number: 20140363445Abstract: The present invention relates generally to the field of cancer therapy and prophylaxis. More particularly, the present invention provides growth factor antagonists which inhibit the growth of cancers including tumors and pre-cancerous tissue. Even more particularly, the present invention is directed to antagonists of vascular endothelial growth factor-B and their use to inhibit the growth of cancer including tumor tissue and pre-cancerous tissue.Type: ApplicationFiled: August 11, 2014Publication date: December 11, 2014Applicant: ZENYTH OPERATIONS PTY LTDInventors: Andrew Nash, Felicity Meredith Dunlop, Manuel Baca, Louis Jerry Fabri, Pierre David Scotney
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Patent number: 8822644Abstract: The present invention relates generally to the field of cancer therapy and prophylaxis. More particularly, the present invention provides growth factor antagonists which inhibit the growth of cancers including tumors and pre-cancerous tissue. Even more particularly, the present invention is directed to antagonists of vascular endothelial growth factor-B and their use to inhibit the growth of cancer including tumor tissue and pre-cancerous tissue.Type: GrantFiled: August 2, 2005Date of Patent: September 2, 2014Assignee: Zenyth Operations Pty LtdInventors: Andrew Nash, Felicity Meredith Dunlop, Manuel Baca, Louis Jerry Fabri, Pierre David Scotney
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Patent number: 8506960Abstract: Binding members for alpha chain of receptor for granulocyte macrophage colony stimulating factor (GM-CSFR?), especially antibody molecules. Use of the binding members in treating inflammatory and autoimmune diseases, e.g. rheumatoid arthritis, asthma, allergic response, multiple sclerosis, myeloid leukaemia and atherosclerosis.Type: GrantFiled: March 27, 2007Date of Patent: August 13, 2013Assignees: MedImmune Limited, Zenyth Operations Pty. Ltd.Inventors: Emma Suzanne Cohen, Ralph Raymond Minter, Paula Rosamund Harrison, Matthew Alexander Sleeman, Andrew Donald Nash, Louis Jerry Fabri
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Patent number: 8221755Abstract: The present invention relates generally to antibodies that bind to the Interleukin-13 receptor.alpha.1 chain (IL-13R.alpha.1) and antagonize IL-13 receptor-mediated signaling by IL-13 and/or IL-4. More particularly, the present invention provides humanized or human antibodies to mammalian and in particular IL-13R.alpha.1. These antibodies have uses in the treatment or prevention of IL-13- and/or IL-4-mediated diseases or conditions. The present invention further contemplates a method of modulating IL-13- and/or IL-4-mediated diseases or conditions by the administration of the subject antibodies. The present invention further provides an assay system useful for identifying antibodies or other agents which modulate IL-13 and/or IL-4 signaling through an IL-13 receptor complex. Accordingly, a method of screening for modulators of IL-13R.alpha.1/ligand interaction is also provided.Type: GrantFiled: July 1, 2010Date of Patent: July 17, 2012Assignee: Zenyth Operations Pty Ltd.Inventors: Felicity Meredith Dunlop, Manuel Baca, Andrew Donald Nash, Louis Jerry Fabri, Douglas James Hilton, Nicos A. Nicola
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Publication number: 20110020363Abstract: The present invention relates generally to antibodies that bind to the Interleukin-13 receptor.alpha.1 chain (IL-13R.alpha.1) and antagonize IL-13 receptor-mediated signaling by IL-13 and/or IL-4. More particularly, the present invention provides humanized or human antibodies to mammalian and in particular IL-13R.alpha.1. These antibodies have uses in the treatment or prevention of IL-13- and/or IL-4-mediated diseases or conditions. The present invention further contemplates a method of modulating IL-13- and/or IL-4-mediated diseases or conditions by the administration of the subject antibodies. The present invention further provides an assay system useful for identifying antibodies or other agents which modulate IL-13 and/or IL-4 signaling through an IL-13 receptor complex. Accordingly, a method of screening for modulators of IL-13R.alpha.1/ligand interaction is also provided.Type: ApplicationFiled: July 1, 2010Publication date: January 27, 2011Applicant: ZENYTH OPERATIONS PTY LTD.Inventors: Felicity Meredith DUNLOP, Manuel BACA, Andrew Donald NASH, Louis Jerry FABRI, Douglas James HILTON, Nicos A. NICOLA
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Patent number: 7785590Abstract: The present invention relates generally to antibodies that bind to the Interleukin-13 receptor ?1 chain (IL-13R?1) and antagonize IL-13 receptor-mediated signaling by IL-13 and/or IL-4. More particularly, the present invention provides humanized or human antibodies to mammalian and in particular IL-13R?1. These antibodies have uses in the treatment or prevention of IL-13- and/or IL-4-mediated diseases or conditions. The present invention further contemplates a method of modulating IL-13- and/or IL-4-mediated diseases or conditions by the administration of the subject antibodies. The present invention further provides an assay system useful for identifying antibodies or other agents which modulate IL-13 and/or IL-4 signaling through an IL-13 receptor complex. Accordingly, a method of screening for modulators of IL-13R?1/ligand interaction is also provided.Type: GrantFiled: May 20, 2004Date of Patent: August 31, 2010Assignee: Zenyth Operations Pty Ltd.Inventors: Felicity Meredith Dunlop, Manuel Baca, Andrew Donald Nash, Louis Jerry Fabri, Douglas James Hilton, Nicos A Nicola
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Publication number: 20090285831Abstract: The present invention relates generally to immunointeractive molecules and more particularly antibodies which bind to vascular endothielial growth factor-B (VEGF-B) or its functional or structural equivalent and inhibit the biological activity of VEGF-B. In particular the present invention relates to deimmunized such as humanized or human antibodies that bind to VEGF-B and inhibit the biological activity of VEGF-B. These antibodies have uses in the treatment or prevention of diseases associated with perturbations in normal vasculogenesis or angiogenesis or vascular remodelling. The present invention further contemplates a method of modulating diseases associated with perturbations in normal vasculogenesis or angiogenesis or vascular remodelling by the administration of the subject antibodies. The present invention further provides an assay system useful for identifying antibodies which bind to VEGF-B and block the biological activity of VEGF-B.Type: ApplicationFiled: March 13, 2009Publication date: November 19, 2009Applicant: ZENYTH OPERATIONS PTY LTDInventors: Andrew NASH, Giuseppe MACCARONE, Pierre David SCOTNEY
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Patent number: 7517524Abstract: The present invention relates generally to immunointeractive molecules and more particularly antibodies which bind to vascular endothelial growth factor-B (VEGF-B) or its functional or structural equivalent and inhibit the biological activity of VEGF-B. In particular, the present invention relates to deimmunized such as humanized or human antibodies that bind to VEGF-B and inhibit the biological activity of VEGF-B. These antibodies have uses in the treatment or prevention of diseases associated with perturbations in normal vasculogenesis or angiogenesis or vascular remodelling. The present invention further contemplates a method of modulating diseases associated with perturbations in normal vasculogenesis or angiogenesis or vascular remodelling by the administration of the subject antibodies. The present invention further provides an assay system useful for identifying antibodies which bind to VEGF-B and block the biological activity of VEGF-B.Type: GrantFiled: January 12, 2007Date of Patent: April 14, 2009Assignee: Zenyth Operations Pty LtdInventors: Andrew Nash, Giuseppe Maccarone, Pierre David Scotney
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Publication number: 20080009444Abstract: The present invention relates generally to a biologically active complex comprising at least two heterologous molecules. More particularly, the biologically active complex of the present invention comprises at least two polypeptides or parts, fragments, truncates or protease-activated forms of one or more of the polypeptides wherein the complex alone or in association with a receptor, ligand or other molecule facilitates proliferation, differentiation and/or survival of a cell. The identification of the biologically active complex of the present invention permits the assay for agonists and antagonists of the formation of the biologically active complex as well as therapeutic and diagnostic reagents based on the biologically active complex or interaction between the biologically active complex and a receptor, ligand or other molecule.Type: ApplicationFiled: February 8, 2007Publication date: January 10, 2008Applicant: Zenyth Operations Pty LtdInventors: Andrew Nash, Kim Jachno, Louis Fabri, Kate Reid, Perry Bartlett, Douglas Hilton, Yasuhiko Nakata, Masakazu Hasegawa
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Publication number: 20070212372Abstract: The present invention relates to a method for the treatment and/or prophylaxis of a nervous system disease, demyelinating disease and/or an inflammatory disease of either the central or peripheral nervous system such as but not limited to an encephalopathic condition and even more particularly an encephalomyelopathic condition. The present invention further provides the use of leukemia inhibitory factor or derivatives, homologues or analogues thereof in the treatment and/or prophylaxis of a nervous system disease, demyelinating disease and/or an inflammatory disease of either the central or peripheral nervous system. Leukemia inhibitory factor may be used alone or in combination with one or more other therapeutic molecules.Type: ApplicationFiled: May 3, 2007Publication date: September 13, 2007Applicant: Zenyth Operations Pty LtdInventors: Kylie Shipham, Tamara Bucci, Helmut Butzkueven, Trevor Kilpatrick, Perry Bartlett, Merja Soilu-Hanninen
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Patent number: 7220828Abstract: The present invention relates generally to a novel haemopoietin receptor or derivatives thereof and to genetic sequences encoding same. Interaction between the novel receptor of the present invention and a cytokine ligand facilitates proliferation, differentiation and survival of a wide variety of cells. The novel receptor and its derivatives and the genetic sequences encoding same of the present invention are useful in the development of a wide range of agonists, antagonists, therapeutics and diagnostic reagents based on ligand interaction with its receptor.Type: GrantFiled: March 10, 1998Date of Patent: May 22, 2007Assignee: Zenyth Operations Pty LtdInventors: Tracy Willson, Nicos A. Nicola, Douglas J. Hilton, Jian-Guo Zhang, Alison Farley, Warren Alexander, Steven Rakar, Yasufumi Kikuchi, Tetsuo Kojima, Masatsugu Maeda, Louis Fabri, Andrew Nash
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Patent number: 7192576Abstract: The present invention relates generally to a biologically active complex comprising at least two heterologous molecules. More particularly, the biologically active complex of the present invention comprises at least two polypeptides or parts, fragments, truncates or protease-activated forms of one or more of the polypeptides wherein the complex alone or in association with a receptor, ligand or other molecule facilitates proliferation, differentiation and/or survival of a cell. The identification of the biologically active complex of the present invention permits the assay for agonists and antagonists of the formation of the biologically active complex as well as therapeutic and diagnostic reagents based on the biologically active complex or interaction between the biologically active complex and a receptor, ligand or other molecule.Type: GrantFiled: October 6, 2000Date of Patent: March 20, 2007Assignee: Zenyth Operations Pty Ltd.Inventors: Andrew Nash, Kim Maree Jachno, Louis J. Fabri, Kate Reid, Perry F. Bartlett, Douglas J. Hilton, Yasuhiko Nakata, Masakazu Hasegawa
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Patent number: 7186883Abstract: The present invention relates to the use of leukemia inhibitory factor (LIF) in the isolation and propagation of embryonic stem cells in vitro.Type: GrantFiled: April 12, 2002Date of Patent: March 6, 2007Assignee: Zenyth Operations Pty Ltd.Inventors: Robert Lindsay Williams, Nicholas Martin Gough, Douglas James Hilton
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Patent number: 7173001Abstract: The present invention relates to a method for regulating neuron development/maintenance and/or regeneration in a nervous system of a mammal and to pharmaceutical compositions comprising leukaemia inhibitory factor useful for same.Type: GrantFiled: April 24, 2003Date of Patent: February 6, 2007Assignee: Zenyth Operations Pty Ltd.Inventors: Perry Bartlett, Mark Murphy
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Publication number: 20060294608Abstract: The present invention relates generally to a novel haemopoietin receptor or derivatives thereof and to genetic sequences encoding same. Interaction between the novel receptor of the present invention and a cytokine ligand facilitates proliferation, differentiation and survival of a wide variety of cells. The novel receptor and its derivatives and the genetic sequences encoding same of the present invention are useful in the development of a wide range of agonists, antagonists, therapeutics and diagnostic reagents based on ligand interaction with its receptor.Type: ApplicationFiled: August 24, 2006Publication date: December 28, 2006Applicant: Zenyth Operations Pty LtdInventors: Douglas Hilton, Nicos Nicola, Alison Farley, Tracy Willson, Jian-Guo Zhang, Warren Alexander, Steven Rakar, Louis Fabri, Tetsuo Kojima, Masatsugu Maeda, Yasufumi Kikuchi, Andrew Nash