Patents Assigned to Zeria Pharmaceutical Co
-
Patent number: 8772528Abstract: Provided is a method for selectively demethylating a 2-methoxy group. Specifically provided is a production method of a compound represented by formula (7) below through the following reactions.Type: GrantFiled: October 29, 2013Date of Patent: July 8, 2014Assignee: Zeria Pharmaceutical Co., Ltd.Inventors: Masaaki Nagasawa, Kazuyasu Asami, Ryu Nakao, Nobuyuki Tanaka, Yoshiyuki Aida
-
Publication number: 20140058104Abstract: Provided is a method for selectively demethylating a 2-methoxy group. Specifically provided is a production method of a compound represented by formula (7) below through the following reactions.Type: ApplicationFiled: October 29, 2013Publication date: February 27, 2014Applicant: ZERIA PHARMACEUTICAL CO., LTD.Inventors: Masaaki NAGASAWA, Kazuyasu Asami, Ryu Nakao, Nobuyuki Tanaka, Yoshiyuki Aida
-
Publication number: 20140058112Abstract: Provided is a method for selectively demethylating a 2-methoxy group. Specifically provided is a production method of a compound represented by formula (7) below through the following reactions.Type: ApplicationFiled: October 29, 2013Publication date: February 27, 2014Applicant: ZERIA PHARMACEUTICAL CO., LTD.Inventors: Masaaki NAGASAWA, Kazuyasu Asami, Ryu Nakao, Nobuyuki Tanaka, Yoshiyuki Aida
-
Publication number: 20140046088Abstract: Provided is a method for selectively demethylating a 2-methoxy group. Specifically provided is a production method of a compound represented by formula (7) below through the following reactions.Type: ApplicationFiled: October 29, 2013Publication date: February 13, 2014Applicant: ZERIA PHARMACEUTICAL CO., LTD.Inventors: Masaaki NAGASAWA, Kazuyasu Asami, Ryu Nakao, Nobuyuki Tanaka, Yoshiyuki Aida
-
Patent number: 8586761Abstract: Provided is a method for selectively demethylating a 2-methoxy group. Specifically provided is a production method of a compound represented by formula (7) below through the following reactions.Type: GrantFiled: August 23, 2005Date of Patent: November 19, 2013Assignee: Zeria Pharmaceutical Co., Ltd.Inventors: Masaaki Nagasawa, Kazuyasu Asami, Ryu Nakao, Nobuyuki Tanaka, Yoshiyuki Aida
-
Publication number: 20130253222Abstract: Provided is a method for effectively producing a 4,5-dialkoxy-2-hydroxybenzoic acid from an inexpensive raw material. A method for producing a 2-bromo-4,5-dialkoxybenzoic acid represented by the following formula (2): (wherein each of R1 and R2 represents a lower alkyl group), the method including causing a 3,4-dialkoxybenzoic acid represented by the following formula (1): (wherein R1 and R2 have the same meanings as defined above) to react with bromine in concentrated hydrochloric acid.Type: ApplicationFiled: December 6, 2011Publication date: September 26, 2013Applicant: Zeria Pharmaceutical Co., LTDInventor: Ryu Nakao
-
Patent number: 8501772Abstract: A method for treatment of a systemic wasting disease, by administering, to a subject in need thereof, an effective amount of a 3,8-diaminotetrahydroquinoline derivative represented by formula (Ia) (wherein X represents CH2, C?O, CH—OR, CH—SR, or CH—NRR?; m is a number of 1 or 2; Ar represents a phenyl group, a naphthyl group, a 5-membered or 6-membered aromatic heterocyclic group having one or two elements selected from S, N, and O, or a similar group; R1 and R2, which may be identical to or different from each other, each represent a hydrogen atom or a methyl group; R3 represents a C1 to C6 alkyl group or a similar group; n is a number of 0 or 1; R4 and R5, which may be identical to or different from each other, each represent a hydrogen atom, or a C1 to C6 alkyl group, etc.; and R6, R7, R, and R?, which may be identical to or different from one another, each represent a hydrogen atom or a C1 to C6 alkyl group), or a salt thereof.Type: GrantFiled: September 14, 2012Date of Patent: August 6, 2013Assignee: Zeria Pharmaceutical Co., Ltd.Inventors: Takeshi Watanabe, Masaru Terauchi, Masaaki Nagasawa, Kouichirou Tanaka, Masataka Washiduka
-
Patent number: 8454995Abstract: To provide a peroral tablet for bowel cleansing which leaves no remains in the intestinal tract after bowel cleansing, which exhibits a dissolution property equivalent to that of conventional sodium phosphate-containing tablets including crystalline cellulose, and which is a small-size agent readily taken by a subject. The peroral tablet for bowel cleansing containing the following ingredients (A) and (B): (A) 80 to 95 mass % of sodium phosphate, and (B) (B1) 7 to 11 mass % of hydroxypropyl cellulose which has such a particle size that ?99% of the particles thereof pass through a mesh having an opening of 350 ?m and whose 2-mass % aqueous solution has a viscosity of 2.0 to 10.0 mPa.s, (B2) 5 to 13 mass % of hydroxypropyl cellulose which has such a particle size that ?99% of the particles thereof pass through a mesh having an opening of 150 ?m and whose 2-mass % aqueous solution has a viscosity of 3.0 to 5.9 mPa.Type: GrantFiled: August 27, 2010Date of Patent: June 4, 2013Assignee: Zeria Pharmaceutical Co., Ltd.Inventors: Masafumi Nomura, Tetsuyuki Nishiyama, Mari Ichikawa, Kyoko Fukaya
-
Publication number: 20130012537Abstract: A method for treatment of a systemic wasting disease, by administering, to a subject in need thereof, an effective amount of a 3,8-diaminotetrahydroquinoline derivative represented by formula (Ia) (wherein X represents CH2, C?O, CH—OR, CH—SR, or CH—NRR?; m is a number of 1 or 2; Ar represents a phenyl group, a naphthyl group, a 5-membered or 6-membered aromatic heterocyclic group having one or two elements selected from S, N, and O, or a similar group; R1 and R2, which may be identical to or different from each other, each represent a hydrogen atom or a methyl group; R3 represents a C1 to C6 alkyl group or a similar group; n is a number of 0 or 1; R4 and R5, which may be identical to or different from each other, each represent a hydrogen atom, or a C1 to C6 alkyl group, etc.; and R6, R7, R, and R?, which may be identical to or different from one another, each represent a hydrogen atom or a C1 to C6 alkyl group), or a salt thereof.Type: ApplicationFiled: September 14, 2012Publication date: January 10, 2013Applicant: ZERIA PHARMACEUTICAL CO., LTD.Inventors: Takeshi WATANABE, Masaru Terauchi, Masaaki Nagasawa, Kouichirou Tanaka, Masataka Washiduka
-
Patent number: 8329913Abstract: An object of the present invention is to provide novel carbazole derivatives, solvates thereof, or pharmaceutically acceptable salts thereof having an excellent adipose tissue weight reducing effect, hypoglycemic effect, and hypolipidemic effect, which are useful as a preventive and/or therapeutic agent for fatty liver, obesity, lipid metabolism abnormality, visceral adiposity, diabetes, hyperlipemia, impaired glucose tolerance, hypertension, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, and the like.Type: GrantFiled: October 28, 2005Date of Patent: December 11, 2012Assignee: Zeria Pharmaceutical Co., Ltd.Inventors: Masakazu Murata, Yoshihiko Itokazu, Ryu Nakao
-
Patent number: 8299255Abstract: To provide a compound which has a potent agonistic activity on GHS-R and which is useful as a therapeutic agent for systemic wasting diseases such as cachexia. A 3,8-diaminotetrahydroquinoline derivative represented by formula (1a) (wherein X represents CH2, C?O, CH—OR, CH—SR, or CH—NRR?; m is a number of 1 or 2; Ar represents a phenyl group, a naphthyl group, a 5-membered or 6-membered aromatic heterocyclic group having one or two elements selected from S, N, and O, or a similar group; R1 and R2, which may be identical to or different from each other, each represent a hydrogen atom or a methyl group; R3 represents a C1 to C6 alkyl group or a similar group; n is a number of 0 or 1; R4 and R5, which may be identical to or different from each other, each represent a hydrogen atom, or a C1 to C6 alkyl group, etc.; and R6, R7, R, and R?, which may be identical to or different from one another, each represent a hydrogen atom or a C1 to C6 alkyl group), or a salt thereof.Type: GrantFiled: February 6, 2009Date of Patent: October 30, 2012Assignee: Zeria Pharmaceutical Co., Ltd.Inventors: Takeshi Watanabe, Masaru Terauchi, Masaaki Nagasawa, Kouichirou Tanaka, Masataka Washiduka
-
Publication number: 20120164219Abstract: To provide a peroral tablet for bowel cleansing which leaves no remains in the intestinal tract after bowel cleansing, which exhibits a dissolution property equivalent to that of conventional sodium phosphate-containing tablets including crystalline cellulose, and which is a small-size agent readily taken by a subject. The peroral tablet for bowel cleansing containing the following ingredients (A) and (B): (A) 80 to 95 mass % of sodium phosphate, and (B) (B1) 7 to 11 mass % of hydroxypropyl cellulose which has such a particle size that ?99% of the particles thereof pass through a mesh having an opening of 350 ?m and whose 2-mass % aqueous solution has a viscosity of 2.0 to 10.0 mPa·s, (B2) 5 to 13 mass % of hydroxypropyl cellulose which has such a particle size that ?99% of the particles thereof pass through a mesh having an opening of 150 ?m and whose 2-mass % aqueous solution has a viscosity of 3.0 to 5.Type: ApplicationFiled: August 27, 2010Publication date: June 28, 2012Applicant: ZERIA PHARMACEUTICAL CO., LTD.Inventors: Masafumi Nomura, Tetsuyuki Nishiyama, Mari Ichikawa, Kyoko Fukaya
-
Publication number: 20120010401Abstract: An industrially advantageous method for producing a 1,5-benzodiazepine compound is provided. A compound (5) is obtained according to the reaction scheme shown below, and this compound is used as an intermediate.Type: ApplicationFiled: March 29, 2010Publication date: January 12, 2012Applicant: Zeria Pharmaceutical Co., Ltd.Inventor: Masaru Terauchi
-
Publication number: 20110059956Abstract: To provide a cancer pain therapeutic and/or prophylactic agent which can be administered to a patient for a long period of time from the early stage to the final stage of the cancer pain therapy, instead of conventional non-opioid analgesic agents or opioid analgesic agents. The cancer pain therapeutic and/or prophylactic agent containing, as an active ingredient, a 1,5-benzodiazepine derivative represented by formula (1): (wherein R1 represents a C1-6 alkyl group, R2 represents a phenyl group or a cyclohexyl group, and Y represents a single bond or a C1-4 an alkylene group) or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: May 14, 2009Publication date: March 10, 2011Applicant: ZERIA PHARMACEUTICAL CO., LTD.Inventors: Koji Yoshinaga, Hiroki Hamano, Takayuki Horii
-
Publication number: 20100317693Abstract: To provide a compound which has a potent agonistic activity on GHS-R and which is useful as a therapeutic agent for systemic wasting diseases such as cachexia. A 3,8-diaminotetrahydroquinoline derivative represented by formula (1a) (wherein X represents CH2, C?O, CH—OR, CH—SR, or CH—NRR?; m is a number of 1 or 2; Ar represents a phenyl group, a naphthyl group, a 5-membered or 6-membered aromatic heterocyclic group having one or two elements selected from S, N, and O, or a similar group; R1 and R2, which may be identical to or different from each other, each represent a hydrogen atom or a methyl group; R3 represents a C1 to C6 alkyl group or a similar group; n is a number of 0 or 1; R4 and R5, which may be identical to or different from each other, each represent a hydrogen atom, or a C1 to C6 alkyl group, etc.; and R6, R7, R, and R?, which may be identical to or different from one another, each represent a hydrogen atom or a C1 to C6 alkyl group), or a salt thereof.Type: ApplicationFiled: February 6, 2009Publication date: December 16, 2010Applicant: ZERIA PHARMACEUTICAL CO., LTDInventors: Takeshi Watanabe, Masaru Terauchi, Masaaki Nagasawa, Kouichirou Tanaka, Masataka Washiduka
-
Publication number: 20100286210Abstract: An object of the present invention is to provide novel carbazole derivatives, solvates thereof, or pharmaceutically acceptable salts thereof having an excellent adipose tissue weight reducing effect, hypoglycemic effect, and hypolipidemic effect, which are useful as a preventive and/or therapeutic agent for fatty liver, obesity, lipid metabolism abnormality, visceral adiposity, diabetes, hyperlipemia, impaired glucose tolerance, hypertension, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, and the like.Type: ApplicationFiled: October 28, 2005Publication date: November 11, 2010Applicant: Zeria Pharmaceutical Co., Ltd.Inventors: Masakazu Murata, Yoshihiko Itokazu, Ryu Nakao
-
Publication number: 20100175779Abstract: There is provided a constant-volume dispenser which allows easy and reliable air removal from a syringe. A constant-volume dispensing syringe 10 includes a syringe 12 and a constant-volume dispenser 14. The constant-volume dispenser 14 includes an outer cylinder 26 which extends in the Arrow A direction; an inner cylinder 28 and a spring 30 which are housed in the outer cylinder 26; and a lid member 32 which is fitted to the outer cylinder 26; a pusher 34 which penetrates the outer cylinder 26, the inner cylinder 28 and the lid member 32; and an operation member 36 which, is attached to the outer cylinder 26. in a preparation operation, the operation member 36 is moved from an initial position to a stopping position whereas in operations after the preparation operation, the operation member 36 is moved from a stand-by position to the stopping position.Type: ApplicationFiled: July 23, 2007Publication date: July 15, 2010Applicants: TAISEI KAKO CO., LTD., MEN-DAR WU, ZERIA PHARMACEUTICAL CO., LTD.Inventors: Yukihiro Ogawa, Men-dar Wu
-
Publication number: 20100143366Abstract: To provide a pharmaceutical agent or an antitumor agent useful for the treatment and/or prevention of gastrointestinal cancer, leukemia, pituitary tumor, small cell lung cancer, thyroid cancer, and neuroastrocytoma. The antitumor agent containing, as an active ingredient, a 1,5-benzodiazepine derivative represented by the following formula (1): (wherein R1 represents a C1-6 alkyl group; R2 represents a phenyl group or a cyclohexyl group; and Y represents a single bond or a C1-4 alkylene group) or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: February 18, 2010Publication date: June 10, 2010Applicant: ZERIA PHARMACEUTICAL CO., LTD.Inventors: Koji YOSHINAGA, Daisuke Kawasaki, Yutaka Emori
-
Publication number: 20100086553Abstract: To provide a pharmaceutical agent or an antitumor agent useful for the treatment and/or prevention of gastrointestinal cancer, leukemia, pituitary tumor, small cell lung cancer, thyroid cancer, and neuroastrocytoma. The antitumor agent containing, as an active ingredient, a 1,5-benzodiazepine derivative represented by the following formula (1): (wherein R1 represents a C1-6 alkyl group; R2 represents a phenyl group or a cyclohexyl group; and Y represents a single bond or a C1-4 alkylene group) or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: December 7, 2009Publication date: April 8, 2010Applicant: ZERIA PHARMACEUTICAL CO., LTD.Inventors: Koji YOSHINAGA, Daisuke Kawasaki, Yutaka Emori
-
Publication number: 20090156652Abstract: A therapeutic agent for impaired gastric accommodation which contains as an active ingredient a compound represented by the general formula (1): (wherein R1 represents a hydrogen atom, a hydroxyl group or a halogen atom; A represents a furyl group, a thienyl group, a thiazolyl group or an oxazolyl group; R2 and R3 each represents an alkyl group with 1 to 5 carbon atoms; and n represents an integer of 2 to 4), or an acid addition salt thereof. Use of a therapeutic agent of the present invention greatly alleviates symptoms caused by said disorders, such as early satiety and bloating, because it improves relaxation of gastric fundus and impaired gastric accommodation.Type: ApplicationFiled: February 17, 2009Publication date: June 18, 2009Applicant: ZERIA PHARMACEUTICAL CO., LTD.Inventors: Yugo Matsunaga, Shigeru Ueki, Hiroki Kato, Shiro Kobayashi