Abstract: A haemostasis device (200) comprises a low pressure seal (206) and a high pressure seal (208). A tubular bayonet (201) is movable from a retracted configuration to an inserted configuration to move the low pressure seal (206) between a closed configuration and an open configuration. With the low pressure seal (206) in the open configuration, a guidewire (222) may be inserted through the low pressure seal (206), and with the low pressure seal (206) in the closed configuration, the guidewire (222) may be passed through the low pressure seal (206) while maintaining sealing around the guidewire (222). A collet (209) is movable in a radial direction to move the high pressure seal (208) between an open configuration and a sealing configuration. With the high pressure seal (208) in the sealing configuration, the guidewire (222) is locked in position.

Abstract: An interventional medical closure device comprises a first engagement element for engagement with an external surface of a vessel on a first side of an opening 8 through the vessel wall and a second engagement element for engagement with an external surface on a second side of the opening. A closure element extends from the first engagement element, into the vessel, and to the second engagement element to assist in closure of the opening. The device may comprise a foot element to engage the internal surface of the vessel on both sides of the opening. The foot element may provide a guide with a pathway for the closure element.

Abstract: An interventional medical closure device is suitable for assisting closure of an opening through a blood vessel wall after completion of an interventional procedure within the internal lumen of the blood vessel. The device comprises a closure element, a grasping element for grasping the closure element, and a delivery element for delivering the closure element into the internal lumen of the blood vessel. The closure element comprises a suture, and an engagement foot at a distal end of the suture. The grasping element is inter-engageable with the closure element to grasp the closure element. The delivery element comprises a main body portion, and a distal nose. The distal nose defines a reception space for carrying the engagment foot of the closure element. The delivery element also comprises an engagement foot which is movable relative to the main body portion between a low-profile delivery configuration and a protruding engagement configuration.