Abstract: An allergic response indicator is provided which comprises a cutaneous three dimensional polymeric sheet capable of self-adherence to the epidermis of a subject and containing an indicator compound distributed throughout said cutaneous three dimensional polymeric sheet which, when applied to said epidermis, is released thereto over the period of application, whereby upon release of said indicator compound an allergic reaction is manifested by visual signs of skin irritation at the site of application upon the removal of said allergic response indicator.