Patents Assigned to ZHEIJIANG HUAHAI TIANCHENG PHARMACEUTICALS CO., LTD.
  • Patent number: 10633329
    Abstract: A method for preparing a lisinopril intermediate is provided. The method includes: treating (R)-hydroxy-4-phenylbutyrate with sulfonyl chloride in an organic solvent in the presence of a base to obtain a solution of sulfonate; reacting the obtained solution with a salt of trifluoroacetyl lysine; and obtaining a N2-[1-(S)-alkoxycarbonyl-3-phenylpropyl]-N6-trifluoroacetyl-L-lysine by separating after the reaction is completed. The method provided has a shorter synthesis route, is easy to operate, has a low cost, and is suitable for industrial production.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: April 28, 2020
    Assignees: ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD., ZHEIJIANG HUAHAI TIANCHENG PHARMACEUTICALS CO., LTD., ZHEJIANG HUAHAI LICHENG PHARMACEUTICALS CO., LTD.
    Inventors: Songqing Wang, Peng Dong, Yang Zheng, Quanjun Li