Abstract: The present disclosure provides a manufacturing process of an arc-shaped bottom titanium cup, including: S1: pressing an inner support ring; S2: primary crystallization; S3: matching; S4: welding opening parts; S5: pressing a titanium cup vacuum bottom; S6: welding the titanium cup vacuum bottom; S7: secondary crystallization; S8: vacuumizing; S9: detecting a thermal insulation function; S10: welding a titanium cup bottom plate; S11: surface polishing; and S12: oxidation processing. The present disclosure provides an inner support ring structure, the inner support ring always holds the titanium cup vacuum bottom round and maintains the titanium cup vacuum bottom in a high degree of roundness, thereby ensuring that a surface of a titanium cup shell and a titanium cup vacuum bottom is flat and smooth. The arc-shaped bottom titanium cup is clamped by adopting an upper mold and a lower mold, so that the arc-shaped bottom titanium cup is accurately limited.