Abstract: A tissue box may include a box unit having a first draw-out opening, and a locating piece, which is partially attached to a surface of the box unit having the first draw-out opening, comprises a second draw-out opening which is located at a position misaligned with the first draw-out opening such that an overlapping portion formed between the first draw-out opening and the second draw-out opening is configured to clamp and limit a position of the following tissue when one tissue is pulled out of the box unit.