Abstract: A system for engaging and locking the cartridge on the body of a cutter holder adapted to equip machines for the industrial cutting of flexible laminates, comprising a slider with a dovetail profile on the lower portion of the cutter holder body, the head portion of the cartridge being provided with a slot with a profile complementary to the profile of the slider for engagement of the cartridge on the cutter holder body, elements for locking the cartridge on the cutter holder body, and a lever for actuating locking elements, which comprise at least one movable element, which applies a symmetrical force with an upward traction component on both sides of the complementary profile of the slot.