Patents Assigned to Zogenix, Inc.
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Patent number: 9662449Abstract: A needle free injector system and a method for delivering a formulation using this system are disclosed. The method comprises actuating a needle free injector to pressurize a liquid formulation and force the formulation through an orifice in a skin puncture phase followed by injection of the formulation during a delivery phase. The skin puncture phase is defined by a pressure profile vs. time curve after actuation which has a main pressure peak with a maximum pressure. The delivery phase occurs at a lower pressure than the maximum pressure of the main peak pressure. The device may have one or more orifices and pressurizing the formulation during the puncture phase and delivery phase to extrude the formulation through each orifice is structured so as to improve characteristics of needle free delivery.Type: GrantFiled: January 15, 2016Date of Patent: May 30, 2017Assignee: Zogenix, Inc.Inventors: Brooks M. Boyd, Jeffrey A. Schuster
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Publication number: 20170143721Abstract: Compositions may include a pharmaceutical active agent, a high viscosity liquid carrier material (HVLCM), a lactic acid-based polymer, and an organic solvent. Related compositions and methods are also disclosed.Type: ApplicationFiled: January 5, 2017Publication date: May 25, 2017Applicants: DURECT CORPORATION, ZOGENIX INC.Inventors: Jeremy C. WRIGHT, Wilma TAMRAZ, John J. LEONARD, John W. GIBSON, Keith E. BRANHAM, Stefania SJOBECK, Brooks BOYD, Christopher M. RUBINO
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Patent number: 9629960Abstract: A needleless injector has a syringe body having an opening at one end, a piston housed within the syringe body for urging a liquid within the syringe body through the opening and a ram for driving the piston. A shock absorbing component is provided for reducing an initial transfer of force from the ram to the piston. The initial rate of pressure increase on the liquid is reduced, thereby controlling the rate of collapse of gas bubbles in the liquid.Type: GrantFiled: August 29, 2014Date of Patent: April 25, 2017Assignee: ZOGENIX, INC.Inventor: Terry Green
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Publication number: 20170065771Abstract: A drug capsule and a method for making a drug capsule for a drug delivery device, such as an auto injector or needle-free injector, with improved stability and container closure integrity. The injector comprises a drug capsule sealed by a piston fabricated from PTFE modified by the inclusion of a co-polymer of PPVE, preferably in an amount less than 1% by weight, resulting in better performance while the device is stored and subjected to temperature cycling.Type: ApplicationFiled: November 21, 2016Publication date: March 9, 2017Applicant: ZOGENIX, INC.Inventors: Geoff NEWELL, Brooks M. BOYD, Philip Justus WUNDERLE, III
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Publication number: 20160206618Abstract: Compositions may include a pharmaceutical active agent, a high viscosity liquid carrier material (HVLCM), a lactic acid-based polymer, and an organic solvent. Related compositions and methods are also disclosed.Type: ApplicationFiled: January 14, 2016Publication date: July 21, 2016Applicants: DURECT CORPORATION, ZOGENIX INC.Inventors: Jeremy C. WRIGHT, Wilma TAMRAZ, John J. LEONARD, John W. GIBSON, Keith E. BRANHAM, Stefania SJOBECK, Brooks BOYD, Christopher M. RUBINO
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Publication number: 20160199579Abstract: Improved needle free injectors comprising of a energy sources, triggering mechanisms, impact members, and drug delivery pistons are disclosed. In one preferred embodiment, the triggering mechanism comprises a spool which seals an energy source comprised of compressed gas and a component for releasing the spool to release the pressurized gas and urge a ram forward to force a drug containing formulation through a drug delivery orifice.Type: ApplicationFiled: January 9, 2012Publication date: July 14, 2016Applicant: ZOGENIX, INC.Inventors: Brooks Boyd, Stephen J. Farr, Jeffery A. Schuster, Andy Fry, Andy Pocock, Brennan Miles, Chris Hurlstone, Joe Daintrey
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Publication number: 20160151571Abstract: Systems and methods are described for treating un-met medical needs in migraine and related conditions such as cluster headache. Included are treatments that are both rapid onset and long acting, which include sustained release formulations, and combination products. Also included are treatments for multiple symptoms of migraine, especially headache and nausea and vomiting. Systems that are self contained, portable, prefilled, and simple to self administer at the onset of a migraine attack are disclosed, and preferably include a needle-free injector and a high viscosity formulation, to eliminate such issues as fear of self administration with needles, and needle stick and cross contamination.Type: ApplicationFiled: February 4, 2016Publication date: June 2, 2016Applicant: ZOGENIX, INC.Inventors: Stephen J. FARR, John TURANIN, Roger HAWLEY, Jeffrey A. SCHUSTER
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Publication number: 20160129191Abstract: A needle free injector system and a method for delivering a formulation using this system are disclosed. The method comprises actuating a needle free injector to pressurize a liquid formulation and force the formulation through an orifice in a skin puncture phase followed by injection of the formulation during a delivery phase. The skin puncture phase is defined by a pressure profile vs. time curve after actuation which has a main pressure peak with a maximum pressure. The delivery phase occurs at a lower pressure than the maximum pressure of the main peak pressure. The device may have one or more orifices and pressurizing the formulation during the puncture phase and delivery phase to extrude the formulation through each orifice is structured so as to improve characteristics of needle free delivery.Type: ApplicationFiled: January 15, 2016Publication date: May 12, 2016Applicant: ZOGENIX, INC.Inventors: BROOKS M. BOYD, Jeffrey A. SCHUSTER
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Patent number: 9265888Abstract: A needle free injector system and a method for delivering a formulation using this system are disclosed. The method comprises actuating a needle free injector to pressurize a liquid formulation and force the formulation through an orifice in a skin puncture phase followed by injection of the formulation during a delivery phase. The skin puncture phase is defined by a pressure profile vs. time curve after actuation which has a main pressure peak with a maximum pressure. The delivery phase occurs at a lower pressure than the maximum pressure of the main peak pressure. The device may have one or more orifices and pressurizing the formulation during the puncture phase and delivery phase to extrude the formulation through each orifice is structured so as to improve characteristics of needle free delivery.Type: GrantFiled: April 14, 2014Date of Patent: February 23, 2016Assignee: ZOGENIX, INC.Inventors: Brooks M. Boyd, Jeffrey A. Schuster
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Patent number: 9259534Abstract: A casing for an injection device of the type having a safety device which prevents operation of the device, incorporating an actuator means by which the safety means of the device can be actuated to allow operation of the device. Also a casing for a medicament container having an opening closed prior to use by a break-off tip, having relatively moveable first and second casing parts, which on relative movement apply a breaking force to the break-off tip. A preferred embodiment includes both such features.Type: GrantFiled: March 26, 2014Date of Patent: February 16, 2016Assignee: Zogenix, Inc.Inventors: Gregor John McLennan Anderson, John Mitchell
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Publication number: 20160038596Abstract: Compositions may include a pharmaceutical active agent, a high viscosity liquid carrier material (HVLCM), a lactic acid-based polymer, and an organic solvent. Related compositions and methods are also disclosed. For instance, a carrier formulation for controlled release of injectable drugs is disclosed. The formulation may include a non-water soluble high viscosity liquid which may be sucrose acetate isobutyrate, a lactic-acid based polymer which may be a poly(lactic acid)(glycolic acid), and an organic solvent which maintains the composition in a monophasic form at 25° C. in one atmosphere. Drug in the formulation may be released upon administration such that less than 10% (e.g. 2-8%) of drug is released in the first 5 hours; 10% to 80% of the drug is released during a period of 5 hours to 7 days after administration; and 10% to 40% of the drug is released gradually over a period of 7 days to 28 days from initial administration. The drug may be an anti-schizophrenia agent delivered by injection.Type: ApplicationFiled: March 11, 2014Publication date: February 11, 2016Applicants: DURECT CORPORATION, ZOGENIX, INC.Inventors: Jeremy C. WRIGHT, Wilma TAMRAZ, John J. LEONARD, John W. GIBSON, Keith E. BRANHAM, Stefania SJOBECK, Brooks Boyd, Christopher M. RUBINO
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Patent number: 9186461Abstract: Formulations are described that are viscous and will benefit from needle-free delivery at high driving pressures. Conventional delivery of these viscous formulations by hypodermic syringes is inconvenient as well as painful. Formulations include those which have a viscosity of about 5 cS or more at about 20° C. and which can have 0.5 ml or more administered by a needle-free injector in about 0.1 second ±0.02 seconds.Type: GrantFiled: July 31, 2012Date of Patent: November 17, 2015Assignee: ZOGENIX, INC.Inventors: Brooks M. Boyd, Sujata Mudumba, Stephen J. Farr
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Patent number: 9138538Abstract: A needle-free injector device comprising a latch having a safe position which disables the triggering of the device, and a ready position which restrains movement of a dispensing member but enables triggering and a triggered position which permits movement of the dispensing member is disclosed. An additional safety mechanism blocks the triggering of the device until removed. A cap is provided to maintain the sterility and stability of the drug formulation and is configured such that the cap removal is required prior to placing the device in a ready to trigger state.Type: GrantFiled: August 30, 2012Date of Patent: September 22, 2015Assignee: ZOGENIX, INC.Inventors: Jeffrey A. Schuster, Paul Stuart Bridges, Graham Gibbins, Nicola Reid
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Publication number: 20140371669Abstract: A needleless injector has a syringe body having an opening at one end, a piston housed within the syringe body for urging a liquid within the syringe body through the opening and a ram for driving the piston. A shock absorbing component is provided for reducing an initial transfer of force from the ram to the piston. The initial rate of pressure increase on the liquid is reduced, thereby controlling the rate of collapse of gas bubbles in the liquid.Type: ApplicationFiled: August 29, 2014Publication date: December 18, 2014Applicant: ZOGENIX, INC.Inventor: TERRY GREEN
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Patent number: 8876758Abstract: Formulations are described that are viscous and will benefit from needle-free delivery at high driving pressures. Conventional delivery of these viscous formulations by hypodermic syringes is inconvenient as well as painful. Formulations include those which have a viscosity of about 5 cS or more at about 20° C. and which can have 0.5 ml or more administered by a needle-free injector in about 0.1 second±0.02 seconds.Type: GrantFiled: April 19, 2011Date of Patent: November 4, 2014Assignee: Zogenix, Inc.Inventors: Brooks M. Boyd, Sujata Mudumba, Stephen J. Farr
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Publication number: 20140308352Abstract: Compositions may include a pharmaceutical active agent, a high viscosity liquid carrier material (HVLCM), a lactic acid-based polymer, and an organic solvent. Related compositions and methods are also disclosed.Type: ApplicationFiled: March 11, 2014Publication date: October 16, 2014Applicants: ZOGENIX INC., DURECT CORPORATIONInventors: Jeremy C. WRIGHT, Wilma TAMRAZ, John J. LEONARD, John W. GIBSON, Keith E. BRANHAM, Stefania SJOBECK, Brooks BOYD, Christopher M. RUBINO
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Publication number: 20140296776Abstract: A casing for an injection device of the type having a safety device which prevents operation of the device, incorporating an actuator means by which the safety means of the device can be actuated to allow operation of the device. Also a casing for a medicament container having an opening closed prior to use by a break-off tip, having relatively moveable first and second casing parts, which on relative movement apply a breaking force to the break-off tip. A preferred embodiment includes both such features.Type: ApplicationFiled: March 26, 2014Publication date: October 2, 2014Applicant: ZOGENIX, INC.Inventors: GREGOR JOHN McLENNAN ANDERSON, JOHN MITCHELL
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Publication number: 20140221915Abstract: A needle free injector system and a method for delivering a formulation using this system are disclosed. The method comprises actuating a needle free injector to pressurize a liquid formulation and force the formulation through an orifice in a skin puncture phase followed by injection of the formulation during a delivery phase. The skin puncture phase is defined by a pressure profile vs. time curve after actuation which has a main pressure peak with a maximum pressure. The delivery phase occurs at a lower pressure than the maximum pressure of the main peak pressure. The device may have one or more orifices and pressurizing the formulation during the puncture phase and delivery phase to extrude the formulation through each orifice is structured so as to improve characteristics of needle free delivery.Type: ApplicationFiled: April 14, 2014Publication date: August 7, 2014Applicant: ZOGENIX, INC.Inventors: BROOKS M. BOYD, JEFFREY A. SCHUSTER
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Patent number: 8734384Abstract: A needle free injector system and a method for delivering a formulation using this system are disclosed. The method comprises actuating a needle free injector to pressurize a liquid formulation and force the formulation through an orifice in a skin puncture phase followed by injection of the formulation during a delivery phase. The skin puncture phase is defined by a pressure profile vs. time curve after actuation which has a main pressure peak with a maximum pressure. The delivery phase occurs at a lower pressure than the maximum pressure of the main peak pressure. The device may have one or more orifices and pressurizing the formulation during the puncture phase and delivery phase to extrude the formulation through each orifice is structured so as to improve characteristics of needle free delivery.Type: GrantFiled: September 14, 2011Date of Patent: May 27, 2014Assignee: Zogenix, Inc.Inventors: Brooks Boyd, Jeffrey A. Schuster
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Patent number: 8715259Abstract: A casing for an injection device of the type having a safety device which prevents operation of the device, incorporating an actuator means by which the safety means of the device can be actuated to allow operation of the device. Also a casing for a medicament container having an opening closed prior to use by a break-off tip, having relatively movable first and second casing parts, which on relative movement apply a breaking force to the break-off tip. A preferred embodiment includes both such features.Type: GrantFiled: September 12, 2012Date of Patent: May 6, 2014Assignee: Zogenix, Inc.Inventors: Gregor John McLennan Anderson, John Mitchell