Abstract: The disclosure provides antimicrobial polymer compositions comprising a plurality of metallic nanoparticles, one or more photosensitizers, and a polymer, wherein the components are combined under high temperature or pressure conditions to form a medical device exhibiting antimicrobial activity under both light and dark conditions without requiring a light-activation source. The disclosure also provides methods of preparing an antimicrobial polymer composition and methods of manufacturing an antimicrobial device with the antimicrobial polymer composition by extrusion, injection molding, pouring, or a combination thereof. The disclosure further provides compositions and methods of preparing antimicrobial products wherein the products are a textile product or a non-textile polymeric article.

Abstract: The disclosure provides antimicrobial bone cement compositions comprising a plurality of metallic nanoparticles, a photosensitizer, and a bone cement, which is mixed to form a metallic nanoparticle-photosensitizer bone cement mixture. This mixture exhibits activity in dark conditions without requiring a light source. The disclosure also provides methods of manufacturing an antimicrobial implant with the antimicrobial metallic nanoparticle-photosensitizer bone cement mixture compositions disclosed by the invention.

Abstract: The invention provides antimicrobial compositions comprising a metallic nanoparticle and a photosensitizer mixed to form a metallic nanoparticle-photosensitizer mixture which has activity in dark conditions without needing a light source. The invention also provides methods of preparing an antimicrobial metallic nanoparticle-photosensitizer mixture compositions and methods of encapsulating a polymer with the antimicrobial metallic nanoparticle-photosensitizer mixture compositions disclosed by the invention.