Patents Assigned to Zuli Holdings Ltd.
-
Patent number: 11633357Abstract: The present invention relates to a liposomal formulation containing a therapeutic agent and a process for producing the formulation. The liposomal formulation comprises particular characteristics that enhance uniformity and stability of the formulation. The manufacturing process is a novel process that produces a liposomal formulation of a uniform size with many desirable properties that may be independently controlled. Further, the invention relates to a liposome formulation made in accordance with the manufacturing process.Type: GrantFiled: March 1, 2019Date of Patent: April 25, 2023Assignee: ZULI HOLDINGS, LTD.Inventors: Yoram Richter, Yehuda Zelig, Omar Elmalak, Dror Eyal
-
Patent number: 10722463Abstract: A method of delivering a pharmaceutical agent into a target organ protected by a blood barrier is provided. The method comprising administering to a subject in need thereof an amount of liposomes which comprise the pharmaceutical agent, the amount and the liposomes are selected such that the liposomes accumulate in cells of an immune system of the subject to thereby generate liposome loaded immune cells, the liposome loaded immune cells become activated and cross the blood barrier, and an effective amount of the pharmaceutical agent is released from the liposomes in the target organ of the subject.Type: GrantFiled: March 6, 2018Date of Patent: July 28, 2020Assignee: Zuli Holdings Ltd.Inventors: Gershon Golomb, Hila Epstein, Eyal Afergan
-
Patent number: 10517883Abstract: A method of treating an acute myocardial infarction by administering to an individual an effective amount of a formulation which inhibits and/or depletes phagocytic cells with high specificity, thereby suppressing the inflammatory response that occurs during and following acute myocardial infarction. The formulation comprises an agent which is an intra-cellular inhibitor that is released within the targeted phagocytic cells, specifically macrophage/monocytes, and inhibits and/or destroys the macrophages and/or monocytes, thereby reducing the final zone of infarct and improving cardiac repair and myocardial remodeling. Since macrophages and monocytes possess the unique ability to phagocytose large bodies, the agent is formulated into a specific size such that it can enter cells primarily via phagocytosis. Thus, the specifically sized formulation selectively targets monocytes/macrophages.Type: GrantFiled: June 27, 2003Date of Patent: December 31, 2019Assignee: ZULI HOLDINGS LTD.Inventors: Haim D. Danenberg, Gershon Golomb, Elazer R. Edelman
-
Patent number: 9956320Abstract: This invention provides a new class of medical devices and implants comprising amorphous metal alloys. The medical devices and implants may be temporary or permanent and may comprise other materials as well, such as polymers, ceramics, and conventional crystalline or polycrystalline metal alloys. Specifically, this invention provides implantable surgical fabrics comprising amorphous metal alloys. The presence of amorphous metal alloys in these fabrics can serve a variety of purposes, including structurally reinforcing the surgical fabric and/or imparting to the fabric the ability to shield against harmful radiation. The fabric may be used inside or outside the body during medical procedures. Further, the implantable surgical fabrics may be woven or non-woven fabrics.Type: GrantFiled: March 18, 2015Date of Patent: May 1, 2018Assignee: Zuli Holdings Ltd.Inventor: Jacob Richter
-
Publication number: 20130273795Abstract: This invention provides a new class of medical devices and implants comprising amorphous metal alloys. The medical devices and implants may be temporary or permanent and may comprise other materials as well, such as polymers, ceramics, and conventional crystalline or polycrystalline metal alloys. Specifically, this invention provides implantable surgical fabrics comprising amorphous metal alloys. The presence of amorphous metal alloys in these fabrics can serve a variety of purposes, including structurally reinforcing the surgical fabric and/or imparting to the fabric the ability to shield against harmful radiation. The fabric may be used inside or outside the body during medical procedures. Further, the implantable surgical fabrics may be woven or non-woven fabrics.Type: ApplicationFiled: June 13, 2013Publication date: October 17, 2013Applicant: ZULI HOLDINGS LTD.Inventor: Jacob RICHTER
-
Patent number: 8496703Abstract: This invention provides a new class of medical devices and implants comprising amorphous metal alloys. The medical devices and implants may be temporary or permanent and may comprise other materials as well, such as polymers, ceramics, and conventional crystalline or polycrystalline metal alloys. Specifically, this invention provides implantable surgical fabrics comprising amorphous metal alloys. The presence of amorphous metal alloys in these fabrics can serve a variety of purposes, including structurally reinforcing the surgical fabric and/or imparting to the fabric the ability to shield against harmful radiation. The fabric may be used inside or outside the body during medical procedures. Further, the implantable surgical fabrics may be woven or non-woven fabrics.Type: GrantFiled: April 28, 2011Date of Patent: July 30, 2013Assignee: Zuli Holdings Ltd.Inventor: Jacob Richter
-
Patent number: 8202280Abstract: The present invention relates to a device for the non-surgical clipping of aneurysms. The invention also includes methods of use to treat aneurysms, including intracranial aneurysms. The aneurysm is clipped by positioning a wire comprising a shape memory alloy, pre-set to a mutually twisted conformation, on opposite sides of the neck of the aneurysm and causing the wires to twist around each other. Thus, the aneurysm neck is substantially closed. The resulting thrombosis in the aneurysm further excludes the aneurysm from blood flow and pressure.Type: GrantFiled: August 13, 2009Date of Patent: June 19, 2012Assignee: Zuli Holdings Ltd.Inventor: Jacob Richter
-
Publication number: 20120123320Abstract: A therapeutic device and therapeutic method for delivering electrical energy or medicament to a body tissue or organ utilizing ultrasonic vibration to cause a device implanted in the body tissue or organ to be treated to discharge and electrical current or medicament to the target area.Type: ApplicationFiled: January 26, 2012Publication date: May 17, 2012Applicant: ZULI HOLDINGS LTD.Inventor: Jacob RICHTER
-
Patent number: 8108041Abstract: A therapeutic device and therapeutic method for delivering electrical energy or a medicament to a body tissue or organ utilizing ultrasonic vibration to cause a device implanted in the body tissue or organ to be treated to discharge an electrical current or medicament to the target area.Type: GrantFiled: February 9, 2006Date of Patent: January 31, 2012Assignee: Zuli Holdings, Ltd.Inventor: Jacob Richter
-
Patent number: 8049088Abstract: An improved string for a musical instrument comprising amorphous metal is disclosed. The string may be a single wire of amorphous metal or comprise a core wire and covering wire, wherein the core wire and/or covering wire comprises amorphous metal. Such a string has greater sustain of sound and higher volume of sound over a longer period of use than previously available metal strings. Musical instruments comprising such strings are also disclosed.Type: GrantFiled: July 1, 2009Date of Patent: November 1, 2011Assignee: Zuli Holdings, Ltd.Inventor: Jacob Richter
-
Publication number: 20110202076Abstract: This invention provides a new class of medical devices and implants comprising amorphous metal alloys. The medical devices and implants may be temporary or permanent and may comprise other materials as well, such as polymers, ceramics, and conventional crystalline or polycrystalline metal alloys. Specifically, this invention provides implantable surgical fabrics comprising amorphous metal alloys. The presence of amorphous metal alloys in these fabrics can serve a variety of purposes, including structurally reinforcing the surgical fabric and/or imparting to the fabric the ability to shield against harmful radiation. The fabric may be used inside or outside the body during medical procedures. Further, the implantable surgical fabrics may be woven or non-woven fabrics.Type: ApplicationFiled: April 28, 2011Publication date: August 18, 2011Applicant: Zuli Holdings, Ltd.Inventor: Kobi (Jacob) RICHTER
-
Patent number: 7955387Abstract: This invention provides a new class of medical devices and implants comprising amorphous metal alloys. The medical devices and implants may be temporary or permanent and may comprise other materials as well, such as polymers, ceramics, and conventional crystalline or polycrystalline metal alloys. Specifically, this invention provides implantable surgical fabrics comprising amorphous metal alloys. The presence of amorphous metal alloys in these fabrics can serve a variety of purposes, including structurally reinforcing the surgical fabric and/or imparting to the fabric the ability to shield against harmful radiation. The fabric may be used inside or outside the body during medical procedures. Further, the implantable surgical fabrics may be woven or non-woven fabrics.Type: GrantFiled: October 1, 2008Date of Patent: June 7, 2011Assignee: Zuli Holdings, Ltd.Inventor: Kobi (Jacob) Richter
-
Patent number: 7887584Abstract: This invention provides a new class of medical devices and implants comprising amorphous metal alloys. The medical devices and implants may be temporary or permanent and may comprise other materials as well, such as polymers, ceramics, and conventional crystalline or polycrystalline metal alloys. Specifically, this invention provides an artificial heart component, such as an artificial heart valve or a pacemaker, wherein the artificial heart component includes an amorphous metal alloy component. The artificial heart valve may be a ball valve comprising an amorphous metal alloy cage. Alternatively, the artificial heart valve can include leaves made of amorphous metal alloy. The amorphous metal alloy component may also be a sheath or a strut. The pacemaker containing the amorphous metal alloy may house an energy source which is shielded from the body by the amorphous metal alloy.Type: GrantFiled: October 1, 2008Date of Patent: February 15, 2011Assignee: Zuli Holdings, Ltd.Inventor: Kobi (Jacob) Richter
-
Publication number: 20090299383Abstract: The present invention relates to a device for the non-surgical clipping of aneurysms. The invention also includes methods of use to treat aneurysms, including intracranial aneurysms. The aneurysm is clipped by positioning a wire comprising a shape memory alloy, pre-set to a mutually twisted conformation, on opposite sides of the neck of the aneurysm and causing the wires to twist around each other. Thus, the aneurysm neck is substantially closed. The resulting thrombosis in the aneurysm further excludes the aneurysm from blood flow and pressure.Type: ApplicationFiled: August 13, 2009Publication date: December 3, 2009Applicant: ZULI HOLDINGS LTD.Inventor: Jacob RICHTER
-
Publication number: 20090272246Abstract: An improved string for a musical instrument comprising amorphous metal is disclosed. The string may be a single wire of amorphous metal or comprise a core wire and covering wire, wherein the core wire and/or covering wire comprises amorphous metal. Such a string has greater sustain of sound and higher volume of sound over a longer period of use than previously available metal strings. Musical instruments comprising such strings are also disclosed.Type: ApplicationFiled: July 1, 2009Publication date: November 5, 2009Applicant: ZULI HOLDINGS LTD.Inventor: Jacob RICHTER
-
Patent number: 7601160Abstract: The present invention relates to a device for the non-surgical clipping of aneurysms. The invention also includes methods of use to treat aneurysms, including intracranial aneurysms. The aneurysm is clipped by positioning a wire comprising a shape memory alloy, pre-set to a mutually twisted conformation, on opposite sides of the neck of the aneurysm and causing the wires to twist around each other. Thus, the aneurysm neck is substantially closed. The resulting thrombosis in the aneurysm further excludes the aneurysm from blood flow and pressure.Type: GrantFiled: February 1, 2006Date of Patent: October 13, 2009Assignee: Zuli Holdings, LtdInventor: Jacob Richter
-
Patent number: 7589266Abstract: An improved string for a musical instrument comprising amorphous metal is disclosed. The string may be a single wire of amorphous metal or comprise a core wire and covering wire, wherein the core wire and/or covering wire comprises amorphous metal. Such a string has greater sustain of sound and higher volume of sound over a longer period of use than previously available metal strings. Musical instruments comprising such strings are also disclosed.Type: GrantFiled: August 21, 2006Date of Patent: September 15, 2009Assignee: Zuli Holdings, Ltd.Inventor: Jacob Richter
-
Patent number: 7415883Abstract: A protected resonating sensor may include at least one resonating sensor unit, each sensor unit has one or more vibratable members. The protected sensor includes at least one body of gel for protecting the vibratable member(s) of the sensor. The gel may be disposed on or attached to the sensor unit(s) covering the vibratable member(s) of the sensor unit(s). The gel may also be disposed in an open housing including one or more sensor units, and may cover vibratable members of different sensor units. The sensor unit may be any resonating sensor unit having a resonance frequency that depends on the value of a physical variable in a measurement environment. The protected sensor may also be attached to or included in or formed as part of any suitable device or sensor anchoring device and may also be implanted or inserted into a body or an organism. Methods are described for constructing the gel-protected sensor.Type: GrantFiled: June 28, 2004Date of Patent: August 26, 2008Assignee: Zuli Holdings LtdInventor: Shay Kaplan
-
Patent number: 7169166Abstract: Apparatus for collecting emboli flowing in a lumen. A motor has a longitudinal bore, a friction area within the longitudinal bore, and a guide wire disposed within the longitudinal bore. The guide wire and friction area of the motor are sized and adapted to contact each other and impart friction between the friction area and the guide wire to permit the motor to rotate around the guide wire. A thrombus collecting gutter is attached to the motor. Paddles are attached to motor and are adapted to initiate a spiral blood flow when the motor rotates. The spiral blood flow causes thrombii in the blood to be deflected towards the internal wall of the lumen and be trapped in a thrombus collecting gutter which is positioned on the motor downstream of the paddles.Type: GrantFiled: November 26, 2002Date of Patent: January 30, 2007Assignee: Zuli Holdings, Ltd.Inventor: Jacob Richter
-
Patent number: RE40305Abstract: Apparatus for pulling and positioning an apparatus, e.g., a stent, in the target area of a lumen. In one embodiment, a cylindrically shaped motor has a longitudinal bore, a friction area within the longitudinal bore, and a guide wire disposed within the longitudinal bore. The guide wire and friction area of the motor are sized and adapted to contact each other and impart friction between the friction area and the guide wire to permit the motor to pull a catheter to the target arcs by crawling against the guide wire. In another embodiment, a cylindrical motor having a friction area on its outer surface is disposed within a guide tube.Type: GrantFiled: September 19, 2002Date of Patent: May 6, 2008Assignee: Zuli Holdings Ltd.Inventor: Jacob Richter