Patents Assigned to Zycos Inc.
  • Immunogenic peptides from the HPV E7 protein
    Publication number: 20040229809
    Abstract: The invention provides immunogenic peptides from the HPV type 16 E7 protein that comprise overlapping class I restricted T cell epitopes. Also disclosed are methods of administering DNA molecules encoding these peptides to a host mammal.
    Type: Application
    Filed: June 24, 2003
    Publication date: November 18, 2004
    Applicant: Zycos Inc., a Delaware corporation
    Inventors: Robert G. Urban, Roman M. Chicz, Edward J. Collins, Mary Lynne Hedley
  • Profiling and cataloging expressed protein tags
    Publication number: 20040224338
    Abstract: An expressed protein tag (EPT) profile characteristic for a given cell, the profile including a representation of at least ten different polypeptides expressed by the cell and bound by a given type of multi-ligand binding receptor; and computer-assisted manipulation of such a profile.
    Type: Application
    Filed: March 24, 2004
    Publication date: November 11, 2004
    Applicant: Zycos Inc., a Delaware corporation
    Inventors: Roman M. Chicz, Mary Lynne Hedley, Charles Hsu, Robert G. Urban
  • Peptide epitopes recognized by disease promoting CD4+ T lymphocytes
    Publication number: 20040006202
    Abstract: The invention provides methods for identifying peptide epitopes that activate CD4+ T cells involved in the pathogenesis of diseases, e.g., autoimmune diseases, susceptibility to which is determined by expression of particular class II MHC genes. The invention includes peptides derived from the IA-2 polypeptide by such a method, altered peptide ligands, and methods of therapy involving the use of altered peptide ligands.
    Type: Application
    Filed: March 3, 2003
    Publication date: January 8, 2004
    Applicants: Zycos, Inc. a Delaware corporation, King's College London, an institution incorporated by Royal Charter in England
    Inventors: Mark Peakman, Roman M. Chicz
  • Immunogenic peptides from the HPV E7 protein
    Patent number: 6582704
    Abstract: The invention provides immunogenic peptides from the HPV type 16 E7 protein that comprise overlapping class I restricted T cell epitopes. Also disclosed are methods of administering DNA molecules encoding these peptides to a host mammal.
    Type: Grant
    Filed: January 12, 2001
    Date of Patent: June 24, 2003
    Assignee: Zycos Inc.
    Inventors: Robert G. Urban, Roman M. Chicz, Edward J. Collins, Mary Lynne Hedley
  • Peptide epitopes recognized by disease promoting CD4+ T lymphocytes
    Patent number: 6562943
    Abstract: The invention provides methods for identifying peptide epitopes that activate CD4+ T cells involved in the pathogenesis of diseases, e.g., autoimmune diseases, susceptibility to which is determined by expression of particular class II MHC genes. The invention includes peptides derived from the IA-2 polypeptide by such a method, altered peptide ligands, and methods of therapy involving the use of altered peptide ligands.
    Type: Grant
    Filed: April 20, 2000
    Date of Patent: May 13, 2003
    Assignees: Zycos, Inc., King's College London
    Inventors: Mark Peakman, Roman M. Chicz
  • Microparticles for delivery of nucleic acid
    Publication number: 20020182258
    Abstract: A preparation of microparticles made up of a polymeric matrix, a nucleic acid expression vector, and a lipid. The polymeric matrix includes one or more synthetic polymers having a solubility in water of less than about 1 mg/l. At least 90% of the microparticles have a diameter less than about 100 microns. The nucleic acid is either RNA, at least 50% of which is in the form of closed circles, or circular DNA plasmid molecules, at least 50% of which are supercoiled.
    Type: Application
    Filed: July 18, 2001
    Publication date: December 5, 2002
    Applicant: Zycos Inc., a Delaware corporation
    Inventors: Lynn B. Lunsford, David Putnam, Mary Lynne Hedley
  • Immunogenic peptides from the HPV E7 protein
    Publication number: 20010006639
    Abstract: The invention provides immunogenic peptides from the HPV type 16 E7 protein that comprise overlapping class I restricted T cell epitopes. Also disclosed are methods of administering DNA molecules encoding these peptides to a host mammal.
    Type: Application
    Filed: January 12, 2001
    Publication date: July 5, 2001
    Applicant: Zycos, Inc., Delaware corporation
    Inventors: Robert G. Urban, Roman M. Chiez, Edward J. Collins, Mary Lynne Hedley
  • Immunogenic peptides from the HPV E7 protein
    Patent number: 6183746
    Abstract: The invention provides immunogenic peptides from the HPV type 16 E7 protein that comprise overlapping class I restricted T cell epitopes. Also disclosed are methods of administering DNA molecules encoding these peptides to a host mammal.
    Type: Grant
    Filed: October 9, 1998
    Date of Patent: February 6, 2001
    Assignee: Zycos Inc.
    Inventors: Robert G. Urban, Roman M. Chicz, Edward J. Collins, Mary Lynne Hedley
  • Immunogenic peptides from the HPV E7 protein
    Patent number: 6013258
    Abstract: The invention provides immunogenic peptides from the HPV type 16 E7 protein that comprise overlapping class I restricted T cell epitopes. Also disclosed are methods of administering DNA molecules encoding these peptides to a host mammal.
    Type: Grant
    Filed: October 9, 1997
    Date of Patent: January 11, 2000
    Assignee: Zycos Inc.
    Inventors: Robert G. Urban, Roman M. Chicz, Edward J. Collins, Mary Lynne Hedley