Patents Assigned to Zymenex A/S
  • Process for production and purification of recombinant lysosomal alpha-mannosidase
    Patent number: 8974780
    Abstract: The present invention relates to a process for purification of recombinant alpha-mannosidase, a process for production of alpha-mannosidase, a composition comprising alpha-mannosidase, use of the composition as a medicament, use as a medicament for the treatment of alpha-mannosidosis and a method of treating alpha-mannosidosis and/or alleviating the symptoms of alpha-mannosidosis.
    Type: Grant
    Filed: February 23, 2011
    Date of Patent: March 10, 2015
    Assignee: Zymenex A/S
    Inventors: Jens Fogh, Claes Andersson, Cecilia Weigelt, Pia Hydén, Helena Reuterwall, Stefan Nilsson
  • Process for concentration of a polypeptide
    Patent number: 8809055
    Abstract: The present invention comprises a method of concentrating a composition comprising a polypeptide of interest and the use of such a concentrated composition for the treatment of diseases in mammals, in particular by subcutaneous injection.
    Type: Grant
    Filed: April 26, 2011
    Date of Patent: August 19, 2014
    Assignee: Zymenex A/S
    Inventor: Stefan Nilsson
  • PROCESS FOR PRODUCTION AND PURIFICATION OF RECOMBINANT LYSOSOMAL ALPHA-MANNOSIDASE
    Publication number: 20120308549
    Abstract: The present invention relates to a process for purification of recombinant alpha-mannosidase, a process for production of alpha-mannosidase, a composition comprising alpha-mannosidase, use of the composition as a medicament, use as a medicament for the treatment of alpha-mannosidosis and a method of treating alpha-mannosidosis and/or alleviating the symptoms of alpha-mannosidosis.
    Type: Application
    Filed: February 23, 2011
    Publication date: December 6, 2012
    Applicant: ZYMENEX A/S
    Inventors: Jens Fogh, Claes Andersson, Cecilia Weigelt, Pia Hydén, Helena Reuterwall, Stefan Nilsson
  • Production and Purification of Recombinant Arylsulftase
    Publication number: 20080003211
    Abstract: The present invention pertains to a process for production of recombinant arylsulfatase A in a cell culture system, the process comprising culturing a mammalian cell capable of producing rASA in liquid medium in a system comprising one or more bio-reactors; and concentrating, purifying and formulating the rASA by a purification process comprising one or more steps of chromatography. Other aspects of the invention provides a pharmaceutical composition comprising rASA, which is efficiently endocytosed via the mannose-6-phosphate receptor pathway in vivo as well as a rhASA a medicament and use of a rhASA for the manufacture of a medicament for reducing the galactosyl sulphatide levels within target cells in the peripheral nervous system and/or within the central nervous system in a subject.
    Type: Application
    Filed: January 30, 2005
    Publication date: January 3, 2008
    Applicant: ZYMENEX A/S
    Inventors: Jens Fogh, Claes Andersson, Cecilia Weigelt, Christer Moller, Pia Hyden
  • Process for purification of recombinant porphobilinogen deaminase
    Patent number: 7148048
    Abstract: A process for purification of recombinant porphobilinogen deaminase (rhPBGD) on an industrial scale by starting from a rhPBGD containing extract obtained from a fermentation of a recombinant cell capable of expressing the rhPBGD and the use of the purified product for the preparation of a medicament.
    Type: Grant
    Filed: December 13, 2002
    Date of Patent: December 12, 2006
    Assignee: Zymenex A/S
    Inventors: Jens Fogh, Claes Andersson