Patents Assigned to Zymo Research Corporation
  • Methods for species-level resolution of microorganisms
    Patent number: 11807909
    Abstract: Methods and devices are provided for the identification and/or quantification of microbes. In particular, the methods comprise: (a) extracting DNA from a microbial sample; (b) performing 16S ribosomal RNA gene-targeted sequencing to obtain DNA sequences; and (c) analyzing the DNA sequences to identify the species of the one or more microbes.
    Type: Grant
    Filed: July 20, 2020
    Date of Patent: November 7, 2023
    Assignee: ZYMO RESEARCH CORPORATION
    Inventors: Ryan Kemp, Mike Weinstein, Shuiquan Tang
  • COMPOSITIONS FOR THE STABILIZATION OF CELL-FREE NUCLEIC ACIDS AND METHODS THEREOF
    Publication number: 20220251627
    Abstract: Provided herein are aqueous compositions, kits and methods for the stabilization of cell-free nucleic acids. Provided herein are aqueous compositions for the stabilization of a cell-free nucleic acid (cfNA) population in a blood sample. In certain embodiments, the aqueous composition comprises a polyvinylpyrrolidone (PVP), an apoptosis inhibitor and one or more eryptosis inhibitors.
    Type: Application
    Filed: June 26, 2020
    Publication date: August 11, 2022
    Applicant: ZYMO RESEARCH CORPORATION
    Inventors: Hanjun KIM, Ryan KEMP, Xi-Yu JIA
  • Apparatus and methods centrifugal and magnetic sample isolation
    Patent number: 11406989
    Abstract: Provided herein are devices and methods for sample isolation comprising a planar member configured to rotate around a bearing, and a plurality of apertures positioned at an angle to the planar member. Exemplary embodiments relate generally to the field of sample isolation, and more particularly to sample isolation using centrifugal and magnetic forces.
    Type: Grant
    Filed: April 25, 2019
    Date of Patent: August 9, 2022
    Assignee: ZYMO RESEARCH CORPORATION
    Inventors: Xi-Yu Jia, Samuel Joseph Ollar
  • Methods for nucleic acid capture
    Patent number: 11236325
    Abstract: Solutions, reagents, and methods for nucleic acid purification. In certain aspects, cationic surfactant and, optionally, an anionic surfactant solutions are provided which can be used for phase separation and capture of nucleic acids, such as plasmid or genomic DNA, to a solid phase carrier, such as a mineral matrix.
    Type: Grant
    Filed: April 25, 2018
    Date of Patent: February 1, 2022
    Assignee: ZYMO RESEARCH CORPORATION
    Inventors: Ryan Kemp, Jonathan A. Claypool, Marc E. Van Eden, Xi-Yu Jia
  • Detection of DNA methylation
    Patent number: 11072817
    Abstract: In a first aspect, the invention concerns a method for detecting or quantifying DNA methylation at a locus. In one embodiment, a methylation-sensitive endonuclease is formulated together with a polymerase enzyme in an appropriate reaction mixture such that amplification of DNA occurs in a methylation specific manor. Quantitative DNA amplification at selected loci can be used to determine the level of methylation. Kits and reagents for performing such methods are also provided.
    Type: Grant
    Filed: August 22, 2017
    Date of Patent: July 27, 2021
    Assignee: ZYMO RESEARCH CORPORATION
    Inventors: Xiyu Jia, Onyinyechi Chimaokereke, Lam Nguyen
  • Assays to determine DNA methylation and DNA methylation markers of cancer
    Patent number: 10801060
    Abstract: Methods are provided for determining a genomic methylation profile in a DNA sample. In certain aspects, the methods can be used to determine if a subject has, or is at risk for developing, a bladder cancer or other cancers of the urinary tract. Methods for treatment of such subjects are likewise provided.
    Type: Grant
    Filed: February 24, 2016
    Date of Patent: October 13, 2020
    Assignee: ZYMO RESEARCH CORPORATION
    Inventors: Wei Guo, Paolo Piatti, Xiaojing Yang, Xi-Yu Jia
  • Nucleic acid purification
    Patent number: 10717976
    Abstract: Methods and composition for nucleic acid isolation are provided. In one embodiment, a method is provided for nucleic acid purification from biological samples, such as whole blood samples, extracted with phenol-based denaturing solvents, which does not require phase separation or nucleic acid precipitation. Methods according to the invention may also be used for of small RNAs (e.g., siRNAs or miRNAs) purification and are amenable to automation.
    Type: Grant
    Filed: December 7, 2015
    Date of Patent: July 21, 2020
    Assignee: ZYMO RESEARCH CORPORATION
    Inventors: Stanislav Forman, Xiyu Jia
  • Nucleic acid purification
    Patent number: 10464961
    Abstract: Methods and composition for nucleic acid isolation are provided. In one embodiment, the invention provides a method for nucleic acid purification from biological samples extracted with phenol-based denaturing solvents, which does not require phase separation or nucleic acid precipitation. Methods according to the invention may also be used for differential isolation of RNA and DNA.
    Type: Grant
    Filed: April 28, 2015
    Date of Patent: November 5, 2019
    Assignee: ZYMO RESEARCH CORPORATION
    Inventors: Stanislav Forman, Xiyu Jia
  • Portable sample disruptor apparatus, kits, and methods
    Patent number: 9410115
    Abstract: Apparatuses, kits, and methods for portable sample disruption (e.g., for encouraging cell lysis).
    Type: Grant
    Filed: May 28, 2014
    Date of Patent: August 9, 2016
    Assignee: ZYMO RESEARCH CORPORATION
    Inventors: Nikolas M. Isely, Marc E. Van Eden, Jonathan K. Brown
  • Nucleic acid purification
    Patent number: 9206469
    Abstract: Methods and composition for nucleic acid isolation are provided. In one embodiment, a method is provided for nucleic acid purification from biological samples, such as whole blood samples, extracted with phenol-based denaturing solvents, which does not require phase separation or nucleic acid precipitation. Methods according to the invention may also be used for of small RNAs (e.g., siRNAs or miRNAs) purification and are amenable to automation.
    Type: Grant
    Filed: July 17, 2013
    Date of Patent: December 8, 2015
    Assignee: ZYMO RESEARCH CORPORATION
    Inventors: Stanislav Forman, Xiyu Jia
  • Portable sample disruptor apparatus, kits, and methods
    Patent number: 9150826
    Abstract: Apparatuses, kits, and methods for portable sample disruption (e.g., for encouraging cell lysis).
    Type: Grant
    Filed: March 13, 2012
    Date of Patent: October 6, 2015
    Assignee: Zymo Research Corporation
    Inventors: Nikolas M. Isely, Marc E. Van Eden, Jonathan K. Brown
  • Nucleic acid purification
    Patent number: 9051563
    Abstract: Methods and composition for nucleic acid isolation are provided. In one embodiment, the invention provides a method for nucleic acid purification from biological samples extracted with phenol-based denaturing solvents, which does not require phase separation or nucleic acid precipitation. Methods according to the invention may also be used for differential isolation of RNA and DNA.
    Type: Grant
    Filed: January 12, 2012
    Date of Patent: June 9, 2015
    Assignee: Zymo Research Corporation
    Inventors: Stanislav Forman, Xiyu Jia
  • EPIGENETIC MARKERS FOR DETECTION OF AUTISM SPECTRUM DISORDERS
    Publication number: 20140349977
    Abstract: Methods for determining if a patient has, or is at risk of having, and autism spectrum disorder by detecting epigenetic changes in the genome of the patient. For example, a method can comprise determining the methylation status of one or more genes in a blood sample.
    Type: Application
    Filed: October 12, 2012
    Publication date: November 27, 2014
    Applicant: ZYMO RESEARCH CORPORATION
    Inventors: Xueguang Sun, Xiyu Jia
  • PORTABLE SAMPLE DISRUPTOR APPARATUS, KITS, AND METHODS
    Publication number: 20140342439
    Abstract: Apparatuses, kits, and methods for portable sample disruption (e.g., for encouraging cell lysis).
    Type: Application
    Filed: May 28, 2014
    Publication date: November 20, 2014
    Applicant: ZYMO RESEARCH CORPORATION
    Inventors: Nikolas M. ISELY, Marc E. VAN EDEN, Jonathan K. BROWN
  • Multiple tube stand
    Patent number: D898941
    Type: Grant
    Filed: May 13, 2019
    Date of Patent: October 13, 2020
    Assignee: ZYMO RESEARCH CORPORATION
    Inventor: Samuel J. Ollar
  • Multiple tube opener
    Patent number: D903445
    Type: Grant
    Filed: May 13, 2019
    Date of Patent: December 1, 2020
    Assignee: ZYMO RESEARCH CORPORATION
    Inventor: Samuel J. Ollar
  • Research container
    Patent number: D929606
    Type: Grant
    Filed: September 25, 2019
    Date of Patent: August 31, 2021
    Assignee: ZYMO RESEARCH CORPORATION
    Inventors: Stanislav Forman, Xi-Yu Jia
  • Biological sample collection pad
    Patent number: D937434
    Type: Grant
    Filed: July 8, 2019
    Date of Patent: November 30, 2021
    Assignee: ZYMO RESEARCH CORPORATION
    Inventors: Stanislav Forman, Xi-Yu Jia
  • Specimen collection tube
    Patent number: D965174
    Type: Grant
    Filed: July 17, 2020
    Date of Patent: September 27, 2022
    Assignee: ZYMO RESEARCH CORPORATION
    Inventors: Xi-Yu Jia, Marc E. Van Eden, Stanislav Forman
  • Specimen collection tube
    Patent number: D999400
    Type: Grant
    Filed: March 5, 2021
    Date of Patent: September 19, 2023
    Assignee: ZYMO RESEARCH CORPORATION
    Inventors: Marc E. Van Eden, Stanislav Forman, Ian Forsythe