Patents Assigned to ZymoGenetics, Inc.
  • Novel human kunitz-type inhibitors and methods relating thereto
    Publication number: 20040253686
    Abstract: The present invention provides isolated DNA molecules comprising a DNA segment encoding novel human Kunitz-type inhibitors. Also provided are DNA constructs comprising a first DNA segment encoding a novel human Kunitz-type inhibitor wherein said first DNA segment is operably linked to additional DNA segments required for the expression for the first DNA segment, as well as host cells containing such DNA constructs and methods for producing proteins from the host cells.
    Type: Application
    Filed: October 7, 2003
    Publication date: December 16, 2004
    Applicants: ZymoGenetics, Inc., The University of New Mexico
    Inventors: Cindy A. Sprecher, Walt Kisiel, Donald C. Foster
  • Antibodies that bind human Zven1
    Patent number: 6828425
    Abstract: The present invention provides two members of a new family of human proteins, designated as “Zven.” The Zven1 gene, which resides in human chromosome 3p21.1-3p14.3, is expressed in testicular tissue and peripheral blood lymphocytes.
    Type: Grant
    Filed: August 2, 2002
    Date of Patent: December 7, 2004
    Assignee: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Paul D. Bishop
  • Compositions and methods for improving kidney function
    Patent number: 6827938
    Abstract: Materials and methods for improving kidney function or enhancing proliferation or survival of kidney tubule epithelial cells or epithelial cell precursors in a mammal are disclosed. The methods comprise administering to the mammal a composition comprising a therapeutically effective amount of a zvegf4 protein or a zvegf4 protein-encoding polynucleotide in combination with a pharmaceutically acceptable delivery vehicle. Zvegf4 proteins include, for example, disulfide-bonded dimers of two polypeptide chains, each comprising residues 258-370 of SEQ ID NO:2.
    Type: Grant
    Filed: October 26, 2001
    Date of Patent: December 7, 2004
    Assignee: ZymoGenetics, Inc.
    Inventors: Charles E. Hart, Stavros Topouzis
  • Secreted salivary zsig63 polypeptide
    Patent number: 6828419
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zsig63, a novel secreted salivary protein. The polypeptides, and polynucleotides encoding them, may exhibit anti-microbial activity and may be used in the study or treatment of microbial infections. The polynucleotides encoding zsig63, are located on chromosome 4, and can be used to identify a region of the genome associated with human disease states. The present invention also includes antibodies to the zsig63 polypeptides.
    Type: Grant
    Filed: August 3, 2001
    Date of Patent: December 7, 2004
    Assignee: ZymoGenetics, Inc.
    Inventors: David A. Adler, Paul O. Sheppard
  • Antibodies to growth factor homolog zvegf4
    Publication number: 20040242850
    Abstract: Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 70% identical to residues 52-179 of SEQ ID NO:2 or residues 258-370 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
    Type: Application
    Filed: June 25, 2004
    Publication date: December 2, 2004
    Applicant: ZymoGenetics, Inc.
    Inventors: Teresa Gilbert, Charles E. Hart, Paul O. Sheppard, Debra G. Gilbertson
  • Soluble zalpha11 cytokine receptors
    Publication number: 20040235743
    Abstract: Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for soluble zalpha11 receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block zlapha11 Ligand activity in vitro and in vivo, and may be used in conjunction with zalpha11 Ligand and other cytokines to selectively stimulate the immune system. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
    Type: Application
    Filed: June 18, 2004
    Publication date: November 25, 2004
    Applicant: ZymoGenetics, Inc.
    Inventors: Cindy A. Sprecher, Julia E. Novak, James W. West, Richard D. Holly, Andrew J. Nelson
  • Polynucleotides for mammalian secreted protein, Z1055G2P
    Patent number: 6822082
    Abstract: The present invention provides to polynucleotides and secreted proteins encoded by the polynucleotides. The proteins include a variety of fusion proteins, including fusions comprising a signal peptide selected from the group consisting of signal peptides shown in SEQ ID NO:M, wherein M is an even integer from 2 to 328, operably linked to a second polypeptide. The invention further provides therapeutic and diagnostic methods utilizing the polynucleotides, polypeptides, and antagonists of the polypeptides.
    Type: Grant
    Filed: June 28, 2001
    Date of Patent: November 23, 2004
    Assignee: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Scott R. Presnell
  • Methods for promoting growth of bone, ligament, and cartilage
    Publication number: 20040228870
    Abstract: Methods for promoting growth of bone, ligament, or cartilage in a mammal are disclosed. The methods comprise administering to said mammal a composition comprising a pharmacologically effective amount of a zvegf3 protein in combination with a pharmaceutically acceptable delivery vehicle. Also disclosed are methods for promoting proliferation or differentiation of osteoblasts, osteoclasts, chondrocytes, or bone marrow stem cells comprising culturing the cells in an effective amount of a zvegf3 protein.
    Type: Application
    Filed: September 19, 2003
    Publication date: November 18, 2004
    Applicant: ZymoGenetics, Inc.
    Inventors: Charles E. Hart, Debra G. Gilbertson
  • Methods of decreasing ZVEGF3 activity
    Patent number: 6814965
    Abstract: Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO: 2 or residues 235-345 of SEQ ID NO: 2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
    Type: Grant
    Filed: May 2, 2002
    Date of Patent: November 9, 2004
    Assignee: ZymoGenetics, Inc.
    Inventors: Zeren Gao, Charles E. Hart, Christopher S. Piddington, Paul O. Sheppard, Kimberly E. Shoemaker, Debra G. Gilbertson, James W. West
  • Polynucleotides encoding cytokine receptor zalpha11
    Publication number: 20040204562
    Abstract: Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zalpha11, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zalpha11, are located on chromosome 16, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
    Type: Application
    Filed: November 18, 2003
    Publication date: October 14, 2004
    Applicant: ZymoGenetics, Inc.
    Inventors: Scott R. Presnell, Darrell C. Conklin, Julia E. Novak, Angela K. Hammond
  • Adipocyte-specific protein homologs
    Patent number: 6803450
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zsig37, a novel member of the family of proteins bearing a collagen-like domain and a globular domain. The polypeptides, and polynucleotides encoding them, are involved in dimerization or oligomerization and may be used in the study thereof. The present invention also includes antibodies to the zsig37 polypeptides.
    Type: Grant
    Filed: March 20, 2003
    Date of Patent: October 12, 2004
    Assignee: ZymoGenetics, Inc.
    Inventor: Paul O. Sheppard
  • Cytokine receptor zalpha11 polypeptides
    Patent number: 6803451
    Abstract: Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zalpha11, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zalpha11, are located on chromosome 16, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
    Type: Grant
    Filed: September 13, 2002
    Date of Patent: October 12, 2004
    Assignee: ZymoGenetics, Inc.
    Inventors: Scott R. Presnell, Darrell C. Conklin, Julia E. Novak, Angela K. Hammond
  • Thrombopoietin compositions
    Patent number: 6790439
    Abstract: Compositions of thrombopoietin, methods of reducing adsorption of thrombopoietin to a surface, and methods of stabilizing a composition of thrombopoietin are disclosed. The compositions comprise, in addition to thrombopoietin, a physiologically acceptable buffer, a surface adsorption inhibitor selected from the group consisting of non-ionic surfactants and polyols, and an isotonic amount of a physiologically acceptable salt.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 14, 2004
    Assignee: ZymoGenetics, Inc.
    Inventors: Richard I. Senderoff, Kathleen M. Kontor
  • Method and system for detecting near identities in large DNA databases
    Publication number: 20040171051
    Abstract: The present invention provides a solution to the needs described above through a system and method for efficiently detecting near identities in large DNA databases. The system and method disclosed herein make use of an algorithm used to construct and maintain unique DNA databases wherein the unique database contains no two DNA sequences such that one is nearly identical to a region of the other. The system and method are applicable to problems such as an all against all comparison of all the DNA sequences in a large DNA database, clustering and assembling ESTs into the cDNAs that generated the ESTs, mapping assembled ESTs onto genomic sequence, mapping cDNAs onto genomic sequences and locating alternately spliced cDNAs.
    Type: Application
    Filed: January 21, 2004
    Publication date: September 2, 2004
    Applicant: ZymoGenetics, Inc.
    Inventor: James L. Holloway
  • Tissue sealant compositions
    Patent number: 6780411
    Abstract: Tissue sealant compositions containing human recombinant fibrinogen, human recombinant factor XIII and human recombinant thrombin. Also disclosed are preferred formulations and uses therefore.
    Type: Grant
    Filed: January 17, 2002
    Date of Patent: August 24, 2004
    Assignee: ZymoGenetics, Inc.
    Inventors: Kenneth B. Lewis, Jr., Paul A. Brown, Gerald W. Lasser, Paul D. Bishop
  • Soluble zalpha11 cytokine receptors
    Patent number: 6777539
    Abstract: Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for soluble zalpha11 receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block zlapha11 Ligand activity in vitro and in vivo, and may be used in conjunction with zalpha11 Ligand and other cytokines to selectively stimulate the immune system. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
    Type: Grant
    Filed: April 3, 2001
    Date of Patent: August 17, 2004
    Assignee: ZymoGenetics, Inc.
    Inventors: Cindy A. Sprecher, Julia E. Novak, James W. West, Scott R. Presnell, Richard D. Holly, Andrew J. Nelson
  • Method and system for detecting near identities in large DNA databases
    Patent number: 6775622
    Abstract: The present invention provides a solution to the needs described above through a system and method for efficiently detecting near identities in large DNA databases. The system and method disclosed herein make use of an algorithm used to construct and maintain unique DNA databases wherein the unique database contains no two DNA sequences such that one is nearly identical to a region of the other. The system and method are applicable to problems such as an all against all comparison of all the DNA sequences in a large DNA database, clustering and assembling ESTs into the cDNAs that generated the ESTs, mapping assembled ESTs onto genomic sequence, mapping cDNAs onto genomic sequences and locating alternately spliced cDNAs.
    Type: Grant
    Filed: January 30, 2001
    Date of Patent: August 10, 2004
    Assignee: ZymoGenetics, Inc.
    Inventor: James L. Holloway
  • Mammalian cytokine-like polypeptide-10
    Publication number: 20040152878
    Abstract: A mammalian cytokine-like polypeptide, called Mammalian Cytokine-like polypeptide-10, (Zcyto10), polynucleotides encoding the same, antibodies which specifically bind to the polypeptide, and anti-idiotypic antibodies which bind to the antibodies. Zcyto10 is useful for promoting the healing of wounds and for stimulating the proliferation of platelets.
    Type: Application
    Filed: February 27, 2004
    Publication date: August 5, 2004
    Applicant: ZymoGenetics, Inc.
    Inventors: Darrell C. Conklin, Betty A. Haldeman
  • Novel cytokine ZCYTO18
    Publication number: 20040152125
    Abstract: The present invention relates to ZCYTO18 polynucleotide and polypeptide molecules. The ZCYTO18 is a novel cytokine. The polypeptides may be used within methods for stimulating the proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
    Type: Application
    Filed: March 22, 2004
    Publication date: August 5, 2004
    Applicant: ZymoGenetics, Inc.
    Inventors: Scott R. Presnell, Wayne Kindsvogel
  • Novel secreted proteins
    Publication number: 20040147722
    Abstract: The present invention provides to polynucleotides and secreted proteins encoded by the polynucleotides. The proteins include and cytokines, growth factors, include fusion proteins operably linked to a second polypeptide. The invention further provides therapeutic and diagnostic methods utilizing the polynucleotides, polypeptides, and antagonists of the polypeptides.
    Type: Application
    Filed: February 12, 2004
    Publication date: July 29, 2004
    Applicant: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Scott R. Presnell, David W. Taft