Patents Assigned to ZymoGenetics
  • Mammalian cytokine-like polypeptide-10
    Patent number: 7271246
    Abstract: A mammalian cytokine-like polypeptide, called Mammalian Cytokine-like polypeptide-10, (Zcyto10), polynucleotides encoding the same, antibodies which specifically bind to the polypeptide, and anti-idiotypic antibodies which bind to the antibodies. Zcyto10 is useful for promoting the healing of wounds and for stimulating the proliferation of platelets.
    Type: Grant
    Filed: July 20, 2006
    Date of Patent: September 18, 2007
    Assignee: ZymoGenetics, Inc.
    Inventors: Darrell C. Conklin, Betty A. Haldeman, Angelika Grossmann
  • Human cytokine receptor
    Patent number: 7265203
    Abstract: Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor16.
    Type: Grant
    Filed: October 19, 2004
    Date of Patent: September 4, 2007
    Assignee: ZymoGenetics, Inc.
    Inventors: Scott R. Presnell, Wenfeng Xu, Wayne Kindsvogel, Zhi Chen, Steven D. Hughes
  • Anti-IL-TIF antibodies and methods of making
    Patent number: 7265211
    Abstract: The present invention relates to blocking the activity of IL-TIF polypeptide molecules. IL-TIF is a cytokine involved in inflammatory processes and human disease. The present invention includes anti-IL-TIF antibodies and binding partners, as well as methods for antagonizing IL-TIF using such antibodies and binding partners in IL-TIF-related human inflammatory diseases, amongst other uses disclosed.
    Type: Grant
    Filed: March 24, 2003
    Date of Patent: September 4, 2007
    Assignee: ZymoGenetics, Inc.
    Inventors: Wenfeng Xu, Wayne Kindsvogel, Steven D. Hughes, Yasmin A. Chandrasekher
  • Hybrid vector having a cytomegalovirus enhancer and myeloproliferative sarcoma virus promoter
    Patent number: 7262025
    Abstract: An expression vector capable of expressing high levels of heterologous proteins having a cytomegalovirus (CMV) enhancer 5? upstream from a myeloproliferative sarcoma virus (MPSV) promoter.
    Type: Grant
    Filed: June 18, 2003
    Date of Patent: August 28, 2007
    Assignee: ZymoGenetics, Inc.
    Inventor: Margaret Dow Moore
  • Interferon-like protein Zcyto21
    Patent number: 7252969
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-? at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.
    Type: Grant
    Filed: August 27, 2004
    Date of Patent: August 7, 2007
    Assignee: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Scott R. Presnell, Brian A. Fox, Teresa Gilbert, Betty A. Haldeman, Francis J. Grant
  • Interferon-like protein Zcyto21
    Patent number: 7253261
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-? at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.
    Type: Grant
    Filed: August 27, 2004
    Date of Patent: August 7, 2007
    Assignee: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Scott R. Presnell, Brian A. Fox, Teresa Gilbert, Betty A. Haldeman, Francis J. Grant
  • IL-21 production in prokaryotic hosts
    Patent number: 7250274
    Abstract: The expression vectors and methods using an E. coli expression system for the large scale production of IL-21 are described. The vectors utilize the IL-21 coding sequence with specific changes in nucleotides in order to optimize codons and mRNA secondary structure for translation in E. coli. Using the expression vectors, the IL-21 gene was produced in E. coli to a level of greater than 1 g/L in fed batch fermentation. Also included are OmpT deficient E. coli strains transformed with an IL-21 expression vector.
    Type: Grant
    Filed: December 12, 2003
    Date of Patent: July 31, 2007
    Assignee: ZymoGenetics, Inc.
    Inventors: Chung Chan, Bruce L. Zamost, Douglas C. Covert, Hong Y. Liu, Karen S. De Jongh, Jeffrey D. Meyer, Susan D. Holderman
  • Use of interleukin-19 to treat cervical cancer
    Patent number: 7247444
    Abstract: The present invention relates to the anti-cancer activity of IL-19 polypeptide molecules. IL-19 is a cytokine involved in inflammatory processes and human disease. The present invention includes Use of IL-19 for decreasing proliferation of cervical cancer cells, treating cervical cancer, amongst other uses disclosed. IL-19 polypeptides can be administered alone, or can be fused to cytotoxic moieties, and can be administered in conjunction with radiation or chemotherapeutic agents.
    Type: Grant
    Filed: April 8, 2003
    Date of Patent: July 24, 2007
    Assignee: ZymoGenetics, Inc.
    Inventors: Yasmin A. Chandrasekher, Patricia A. McKernan
  • FGF homolog polypeptides
    Patent number: 7247608
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zFGF-5 a novel member of the FGF family. The polypeptides, and polynucleotides encoding them, are proliferative for muscle cells and may be used for remodelling cardiac tissue and improving cardiac function. The present invention also includes antibodies to the zFGF-5 polypeptides.
    Type: Grant
    Filed: October 19, 2001
    Date of Patent: July 24, 2007
    Assignee: ZymoGenetics, Inc.
    Inventors: Theresa A. Deisher, Darrell C. Conklin, Fenella Raymond, Thomas R. Bukowski, Susan D. Holderman, Birgit Hansen, Paul O. Sheppard
  • Interferon-like protein Zcyto21
    Patent number: 7241870
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-? at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.
    Type: Grant
    Filed: August 27, 2004
    Date of Patent: July 10, 2007
    Assignee: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Scott R. Presnell, Brian A. Fox, Teresa Gilbert, Betty A. Haldeman, Francis J. Grant
  • Materials and methods for preparing dimeric growth factors
    Patent number: 7241593
    Abstract: Proteins consisting of, from amino to carboxyl terminus, a first PDGF-D growth factor domain polypeptide, a linker polypeptide, and a second PDGF-D growth factor domain polypeptide, and materials and methods for making the proteins are disclosed. Each of the first and second PDGF-D growth factor domain polypeptides consists of a sequence of amino acid residues as shown in SEQ ID NO:2 or SEQ ID NO:4 from amino acid x to amino acid y, wherein x is an integer from 246 to 258, inclusive, and y is an integer from 365–370, inclusive. The linker polypeptide consists of from 11–40 amino acid residues. The proteins can be used to stimulate the production of bone and/or connective tissue in both humans and non-human animals.
    Type: Grant
    Filed: February 11, 2003
    Date of Patent: July 10, 2007
    Assignee: ZymoGenetics, Inc.
    Inventors: Brian A. Fox, Margaret Dow Moore, Kristine M. Swiderek, Carl W. Birks
  • Methods for enhancing expression of recombinant proteins
    Patent number: 7235385
    Abstract: The present invention provides two novel E. coli synthetic promoters, Syn 1 and Syn 2. Syn 1 and Syn 2 are two tight regulated synthetic promoters that control uninduced, leaky expression of proteins that are toxic and interfere with production of recombinant protein from an E. coli expression system.
    Type: Grant
    Filed: February 21, 2006
    Date of Patent: June 26, 2007
    Assignee: ZymoGenetics, Inc.
    Inventors: Chung Chan, Tracey A. Pownder
  • Method for treating inflammatory bowel disease
    Publication number: 20070122384
    Abstract: A method for treating inflammatory bowel disease by administering interferon beta in conjunction with factor XIII to a mammal afflicted with the disease. The IBD may either be ulcerative colitis or Crohn's disease. The factor XIII used may be recombinant or nonrecombinant. The interferon beta used can be naturally occurring interferon beta, interferon beta-1a or interferon beta-1b.
    Type: Application
    Filed: December 19, 2006
    Publication date: May 31, 2007
    Applicant: ZYMOGENETICS, INC.
    Inventor: Jan Ohrstrom
  • Four-helical bundle protein zsig81
    Patent number: 7223564
    Abstract: This present invention is directed to polypeptide and polynucleotide molecules that encode a four-helical bundle cytokine. The cytokine has been designated zsig81, and has restricted expression in primarily heart, lung and liver. zsig81 has been shown to stimulate proliferation of hematopoietic cells and will be useful expansion of these cells, as well as conditions associated with hematopoietic cells. The invention is directed to antibodies and methods of making zsig81 polypeptides, as well.
    Type: Grant
    Filed: December 9, 2002
    Date of Patent: May 29, 2007
    Assignee: ZymoGenetics, Inc.
    Inventors: Christopher S. Piddington, James W. West, Richard D. Holly, Steven K. Burkhead
  • UMLR polypeptides
    Patent number: 7217790
    Abstract: Novel secreted and membrane bound tumor necrosis factor receptor (TNFR) polypeptides, polynucleotides encoding the polypeptides, antibodies and related compositions and methods are disclosed. The polypeptides may be used for detecting ligands, agonists and antagonists. The polypeptides, polynucleotides and antibodies may also be used in methods that modulate inflammation, tumor growth and metastasis, infection, immunity, and cellular maturation.
    Type: Grant
    Filed: September 12, 2003
    Date of Patent: May 15, 2007
    Assignee: ZymoGenetics, Inc.
    Inventors: Wenfeng Xu, Catherine E. Lofton-Day, Randal M. Henne, Scott R. Presnell, Yue Yao, Julia E. Novak
  • Adipocyte complement related protein homolog zacrp2
    Patent number: 7208578
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zacrp2, a novel member of the family of proteins bearing a collagen-like domain and a C1q domain. The polypeptides and polynucleotides encoding them, are involved in dimerization or oligomerization and may be used in the study thereof. The present invention also includes antibodies to the zacrp2 polypeptides.
    Type: Grant
    Filed: May 20, 2005
    Date of Patent: April 24, 2007
    Assignee: ZymoGenetics, Inc.
    Inventors: Christopher S. Piddington, Paul D. Bishop
  • Uses of human Zven antagonists
    Patent number: 7205110
    Abstract: The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods of using antagonists to Zven1 and Zven2 to treat inflammation in the intestine.
    Type: Grant
    Filed: October 7, 2003
    Date of Patent: April 17, 2007
    Assignee: ZymoGenetics, Inc.
    Inventors: Penny J. Thompson, Paul O. Sheppard
  • Methods for enhancing the translation and expression of recombinant proteins
    Patent number: 7202077
    Abstract: The increased use of nucleotide sequence data mining techniques has amplified the demand for efficient methods of producing recombinant proteins in prokaryotic cells. A strategy is provided for enhancing the synthesis of recombinant amino acid sequences by improving translation from expression cassettes in vitro before producing recombinant hosts.
    Type: Grant
    Filed: April 12, 2002
    Date of Patent: April 10, 2007
    Assignee: ZymoGenetics, Inc.
    Inventors: Tracey A. Pownder, Chung Chan
  • Heterodimeric four helix bundle cytokines
    Patent number: 7196172
    Abstract: Heterodimeric proteins comprising two helical bundle cytokines are disclosed. One of the polypeptides comprises zsig81 and a second polypeptide which comprises either p19 (aka IL-12A) or p35 (aka L-12A). The proteins may be produced as fusion proteins or expressed as a single chain. The heterdimeric protein comprising zsig81 and p19 is designated zcyto33f2 and the heterodimeric protein comprising zsig81 and p35 is designated zcyto35f2. Zcyto33f2 and zcyto35f2 proteins are associated with epithelial cell types, including lung and gut epithelium, and may play a role in physiological conditions such as inflammation.
    Type: Grant
    Filed: July 14, 2006
    Date of Patent: March 27, 2007
    Assignee: ZymoGenetics, Inc.
    Inventors: James W. West, Stacey Tannheimer
  • Methods for promoting growth of bone, ligament, and cartilage using zvegf4
    Patent number: 7192592
    Abstract: Methods for promoting growth of bone, ligament, or cartilage in a mammal are disclosed. The methods comprise administering to said mammal a composition comprising a pharmacologically effective amount of zvegf4 in combination with a pharmaceutically acceptable delivery vehicle. Also disclosed are methods for promoting proliferation or differentiation of osteoblasts, osteoclasts, chondrocytes, or bone marrow stem cells comprising culturing the cells in an effective amount of zvegf4.
    Type: Grant
    Filed: August 3, 2004
    Date of Patent: March 20, 2007
    Assignee: ZymoGenetics, Inc.
    Inventors: Debra G. Gilbertson, Charles E. Hart