Patents Assigned to Zyomix, Inc.
  • Methods for making antibody fragments and compositions resulting therefrom
    Patent number: 6720165
    Abstract: Improved methods for making antibody fragments, preferably F(ab′)2 fragments from various classes and subclasses of antibodies is described. Pretreatment of antibodies with deglycosylases or cellular inhibition of glycosylation during expression, yields antibodies having improved susceptibility towards protease cleavage, preferably pepsinolysis, which yields F(ab′)2 antibody fragments. Compositions resulting from such methods are further disclosed.
    Type: Grant
    Filed: June 14, 2001
    Date of Patent: April 13, 2004
    Assignee: Zyomix, Inc.
    Inventors: Steffen Nock, David S. Wilson, Jiangchun Wu