Abstract: Compounds of the structure ##STR1## where Ar.sup.1 is selected from optionally substituted carbocyclic aryl; optionally substituted 5- or 6-membered heterocyclic aryl; optionally substituted 10-membered bicyclic heterocyclic aryl containing one or two nitrogen atoms; optionally substituted benzo[b]furyl; optionally substituted benzo[b]thienyl; ##STR2## L.sup.1 is a valence bond, alkylene, propenylene, or propynylene; Y is oxygen, >NR.sup.5, or >S(O)n; Ar.sup.2 is optionally substituted phenyl; L.sup.2 is ##STR3## and R.sup.1 and R.sup.2 are alkyl, or taken together define a group of formula ##STR4## are potent inhibitors of lipoxygenase enzymes and thus inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.