Abstract: A method of preventing transmission of a retrovirus from a mother to her offspring, by administering to the mother a therapeutically effective amount of a composition comprising a Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated endonuclease, and the two or more different multiplex gRNAs, wherein each of the at least two gRNAs is complementary to a different target nucleic acid sequence in a long terminal repeat (LTR) of proviral DNA of the virus that is unique from the genome of the host cell, cleaving a double strand of the proviral DNA at a first target protospacer sequence with the CRISPR-associated endonuclease, cleaving a double strand of the proviral DNA at a second target protospacer sequence with the CRISPR-associated endonuclease, excising an entire HIV-1 proviral genome, eradicating the HIV-1 proviral DNA from the host cell, and preventing transmission of the proviral DNA to the offspring.

Abstract: An apparatus includes a body, a catheter, and an end effector. The catheter extends distally from the body and includes a lumen. The end effector includes at least one electrode. The end effector further includes at least one port in fluid communication with the lumen of the catheter such that the lumen is operable to communicate the fluid from a fluid source to the at least one port. The end effector further includes at least one flexible sleeve positioned over the at least one port, the at least one flexible sleeve being configured to transition between a closed state in which the at least one flexible sleeve prevents the fluid from exiting the at least one port, and an open state in which the at least one flexible sleeve permits the fluid to exit the at least one port.

Abstract: Structures that include resistive memory elements and methods of forming a structure that includes resistive memory elements. The structure comprises a bipolar junction transistor including a base, a first terminal having a first raised semiconductor layer over the base, and a second terminal having a second raised semiconductor layer over the base. The first raised semiconductor layer is spaced in a lateral direction from the second raised semiconductor layer. The structure further comprises a resistive memory element including a first electrode, a second electrode, and a switching layer between the first electrode and the second electrode. The first electrode of the resistive memory element is coupled to the first terminal of the bipolar junction transistor.

Abstract: Provided in the present application are a sidelink communication method, and a device, which relate to the field of mobile communications. The method is applied to a first terminal in sidelink transmission, and includes: executing listen-before-talk (LBT) on a grant-free scheduled resource; and when the LBT consistently fails to be triggered on the grant-free scheduled resource, executing a target operation.

Abstract: A semiconductor structure includes a substrate, an interconnection structure disposed over the substrate and a first memory cell. The first memory cell is disposed over the substrate and embedded in dielectric layers of the interconnection structure. The first memory cell includes a first transistor and a first data storage structure. The first transistor is disposed on a first base dielectric layer and embedded in a first dielectric layer. The first data storage structure is embedded in a second dielectric layer and electrically connected to the first transistor. The first data storage structure includes a first electrode, a second electrode and a storage layer sandwiched between the first electrode and the second electrode.

Abstract: Provided are a method for wireless communication, a terminal device and a storage medium. In the method, the terminal device determines K available transmission resources; and for an i-th available transmission resource in the K available transmission resources, the terminal device determines whether to use the i-th available transmission resource for sidelink transmission according to a result of a channel access procedure, where i and K are positive integers, and 1?i?K.

Abstract: A lateral extent of a gate electrode of a field effect transistor along a gate electrode direction that is perpendicular to a channel direction can be the same as a width of an underlying active region. A gate electrode of an additional field effect transistor may extend over a trench isolation structure that laterally surrounds the additional field effect transistor. Different types of electrodes may be formed by patterning a lower gate material layer and by patterning an upper gate material layer with different patterns such that patterned portions of the lower gate material layer are confined within areas of active regions, while patterned portions of the upper gate material layer extends outside of the areas of the active regions.

Abstract: In an IEEE 802.11 wireless system, a wireless relay STA is configured to receive a MAC control frame to protect a transmission opportunity for a relay operation of frames exchanged between a first STA and a second STA over a wireless relay STA, where the MAC control frame includes TXOP duration information, a receiver address identifying the wireless relay STA, and a transmitter address identifying the first STA, where the wireless relay STA is further configured to transmit an RTS frame in response to receiving the MAC control frame, to receive a CTS frame that is transmitted by the second STA in response to receiving the RTS frame, to transmit a CTS-ACK frame in response to receiving the CTS frame, and to receive and forward a data frame from the first STA which is transmitted at a first TXOP-protected transmission time designated by the TXOP duration information.

Abstract: Cuffless apparatus comprised of a pressure applicator operated at the wrist or other pulse-taking location and a processing unit implementing a method of measurement of arterial blood pressure and detection of auscultatory gap. Applanation pressure is applied by user's fingers in a pulsatile fashion as per real-time instructions of the processing unit. Pressure magnitude and sound field parameters captured by sensors are used to estimate systolic and diastolic blood pressure by analysis of Korotkoff sounds. User instructions are adjusted during measurement to facilitate self-validation by correlating results of two machine learning approaches: recognition of correlation of derivatives of the pressure and sound amplitude as functions of time, and image recognition of Korotkoff events in sound spectrograms overlayed with pressure traces. The auscultatory gap is detected when sound intensity is reduced by at least forty percent for one or more pulse waves.

Abstract: The present invention relates to compounds or pharmaceutical compositions for treating neurological disorders. In particular, the invention relates to a modulator of gamma-Aminobutyric acid (GABA) signaling for use in treating a neurological disorder in a subject with Cyfip1 haploinsufficiency. Furthermore, the present invention relates to a modulator of Aralar for use in treating a neurological disorder. The invention further relates to non-medical uses of the compounds or compositions of the invention. Furthermore, the invention relates to a method for identifying a modulator of Aralar and/or a neuroactive drug.

Abstract: The invention relates to an implantable pressure sensor for measuring pressure, comprising a hermetic capsule (3) with a partially flexible portion; an electronic circuit (4) housed in the capsule (3) generating a transduction pressure signal dependent on the absolute pressure outside the capsule (3); an electrode pair (5, 5?) connected to the electronic circuit (4). The electronic circuit (4) comprises: a digital control unit (29); an interrogation stage (25) receiving an interrogation signal transmitted by volume conduction to the electrode pair (5, 5?), to generate a transduction pressure signal and to transmit it to a medium (15); and a power transferring stage (9) receiving part of the interrogation signal power and transferring power to the digital control unit (29) and to the interrogation stage (25). The invention further comprises a system comprising one or more pressure sensors and a reading unit; and the method for interrogating and powering said system.

Abstract: The present invention provides methods for treating or preventing aggression, agitation, irritability and/or anger in a subject comprising administrating to a subject in need thereof a therapeutically effective amount of a compound of Formula (I).

Abstract: An arrhythmic state detection assisting device includes an acquisition unit, a derivation unit and an estimation unit. The acquisition unit acquires image information obtained by capturing an image of a predetermined part of a subject with an image capture device that captures a color moving image. The derivation unit derives a variance value, for a predetermined interval, of periods of a periodic change in a green luminance component in the image information acquired by the acquisition unit. As the variance value derived by the derivation unit becomes greater, the estimation unit estimates a higher likelihood that an arrhythmia is occurring in the subject.

Abstract: A pharmaceutical composition including a compound of Formula 1 may be used for preventing or treating dengue fever. Specifically, the composition may include ulipristal, ulipristal acetate, or a pharmaceutically acceptable salt thereof, which may inhibit dengue virus infection. The dengue fever may be caused by infection with dengue virus DENV-1, DENV-2, DENV-3 or DENV-4.

Abstract: The present invention relates to a device (200), system (500) and method for determining a vital sign (150) of a subject (1) by using high dynamic range techniques to overcome the problems arising from a non-homogenous illumination of the subject (1). A camera (100) is preferably alternately switched between a mode of a high exposure time and a low exposure time to continuously record electromagnetic radiation (10) transmitted through or reflected from a skin area (4, 6) including one or more skin pixels of the subject (1). A plurality of detection signals (110), each representing a time signal derived from the electromagnetic radiation (10) are then further processed by various method steps, such as selecting high-quality skin-pixels from the different exposure states for signal extraction, interpolating and combining different exposure signals for vital signs extraction to increase the number of skin pixels for a more accurate vital sign extraction.

Abstract: Sustained-release abiraterone prodrug formulations, methods, and kits for parenteral administration to a subject having a sex hormone-dependent benign or malignant disorder such as prostate cancer, an androgen receptor driven cancer, a syndrome due to androgen excess, and/or a syndrome due to glucocorticoid excess such as hypercortisolemia.

Abstract: The system and method for characterizing a tissue of interest may include navigating a needle device in proximity to the tissue of interest. The needle device can comprise a member including a plurality of electroconductive segments. The plurality of electroconductive segments can be electrically insulated from one another. The device can also include a first conductive path electrically coupled to a first electroconductive segment. A second conductive path can be coupled to a second electroconductive segment. The method can include contacting the tissue of interest with the first electrode and determining a tissue impedance of the tissue of interest from an electrical signal from the first electrode. The method can also include characterizing the tissue of interest as malignant or benign based on the tissue impedance.

Abstract: The present disclosure provides a composition comprising a first amount of a Vitamin D compound and a second amount of a probiotic compound. The disclosure also provides a method of treating an atopic condition in a subject in need thereof comprising administering to the subject a therapeutically effective amount of the composition detailed herein.

Abstract: The present disclosure provides apparatuses and computer readable media for measuring sub-epidermal moisture in patients to determine damaged tissue for clinical intervention. The present disclosure also provides methods for determining damaged tissue.

Abstract: Stabilized oral cannabidiol composition comprising cannabidiol (CBD) having a purity of at least 98%. The composition further contains ?-caryophyllene (BCP), at least one additional lipophilic solvent (e.g. medium chain triglycerides (MCT)), and at least one additional antioxidant (e.g. ?-tocopherol (vitamin E)). The composition is substantially free of THC. The CBD can be synthetic, biosynthetic or of botanical origin. Also disclosed are methods of making and the stabilized oral CBD composition.