Patents Examined by A. A.
  • PROCESS FOR PREPARING INTERMEDIATES FOR 1-(4-FLUOROPHENYL)-4-((6bR,10aS)-3-METHYL-2,3,6b,9,10,10a-HEXAHYDRO-1H-PYRIDO[3’,4’:4,5]PYRROLO[1,2,3-de]QUINOXALIN-8(7H)-YL)BUTAN-1-ONE
    Publication number: 20250101022
    Abstract: The present invention provides methods for the preparation of substituted heterocycle fused gamma-carbolines, such as the compound of Formula 1J, as shown below, intermediates useful in producing them and methods for producing such intermediates and such heterocycle fused gamma-carbolines, and as further defined herein:
    Type: Application
    Filed: October 3, 2024
    Publication date: March 27, 2025
    Applicant: INTRA-CELLULAR THERAPIES, INC.
    Inventors: John Charles TOMESCH, Peng LI, Wei YAO, Qiang ZHANG, James David BEARD, Andrew S. THOMPSON, Hua CHENG, Lawrence P. WENNOGLE
  • COMPOSITIONS AND METHODS FOR PROTECTING AGAINST CELL DAMAGE AND INFLAMMATION
    Publication number: 20250101204
    Abstract: High mobility group box protein 1 (HMGB1) is a nuclear protein released during cell damage and stimulates inflammatory and proliferative pathways in the surviving neighboring cells. HMGB1 contains three cysteine residues (e.g., 23/45/106) involved in the extracellular HMGB1 oligomerization and receptor binding. The peptide compositions described herein shield the aforementioned cysteine residues, which block HMGB1 from binding to DNA and, thus, reduce apoptotic signaling within a cell. Furthermore, methods of treating inflammatory disease (e.g., PAH) by administering said peptide composition are described herein.
    Type: Application
    Filed: February 28, 2023
    Publication date: March 27, 2025
    Inventors: Ruslan Rafikov, Olga Rafikova
  • HETEROARYL DERIVATIVE AND USES THEREOF
    Publication number: 20250101023
    Abstract: The present invention relates to a heteroaryl derivative, a stereoisomer thereof, a hydrate thereof, a solvate thereof, or a pharmaceutically acceptable salt thereof, a method for preparing the same, and a pharmaceutical composition for preventing or treating cancer comprising the same as an active ingredient. The heteroaryl derivative of the present invention exhibits high inhibitory activity against overexpressed HER2, and thus, a pharmaceutical composition containing the same as an active ingredient can be usefully used for preventing or treating HER-2 positive cancer.
    Type: Application
    Filed: January 19, 2023
    Publication date: March 27, 2025
    Applicants: IUCF-HYU (INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY), KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Gu KONG, Ratnakar Reddy KUCHUKULLA, Su Min KIM, So Jeong MOON, Woo Young HUR, In Jeong HWANG
  • FLAME-RETARDANT POLYCARBONATE FILM
    Publication number: 20250101206
    Abstract: The present disclosure discloses a flame-retardant PC film, comprising 75-92 parts by weight of at least one PC resin and 10-20 parts by weight of a flame retardant, wherein the flame retardant includes at least one phosphorus-containing flame retardant and at least one inorganic silicon flame retardant.
    Type: Application
    Filed: September 24, 2024
    Publication date: March 27, 2025
    Inventors: Yuxi LANG, Run SU
  • NITROGEN-CONTAINING COMPOUND, ORGANIC ELECTROLUMINESCENT DEVICE, AND ELECTRONIC APPARATUS
    Publication number: 20250101024
    Abstract: The application relates to the technical field of organic electroluminescent materials, and provides a nitrogen-containing compound, and an organic electroluminescent device and an electronic apparatus including the nitrogen-containing compound. The compound of the application has a core structure that is an indolocarbazolyl group fused with cyclohexane. The compound, when used as a host material of an light emitting layer, can improve balance of charge carriers in the light emitting layer, expand a region where the carriers recombine, improve generation and utilization efficiency of excitons as well as luminescence efficiency and service life of the device.
    Type: Application
    Filed: February 27, 2023
    Publication date: March 27, 2025
    Inventors: Xianbin Xu, Lei YANG
  • LIQUID SULFUR POLYMERS FOR IMPROVED TIRE CHARACTERISTICS
    Publication number: 20250101207
    Abstract: A rubber composition is described that includes a rubber component in combination with a high surface area silica, and a polysulfide polymer having the following formula: HS(C2H4—O—CH2—O—C2H4SS)xC2H4—O—CH2—O—C2H4SH wherein x is 5 to 100. The rubber composition can be included in the tread of pneumatic tires to provide tires that exhibit improved mechanical and performance properties.
    Type: Application
    Filed: September 26, 2024
    Publication date: March 27, 2025
    Inventor: Jared J. Griebel
  • NOVEL PLK1 DEGRADATION INDUCING COMPOUND
    Publication number: 20250101025
    Abstract: The present disclosure relates to a novel PLK1 degradation inducing compound, a method for preparing the same, and the use thereof. The compounds of the present disclosure exhibit an effect of inducing PLK1 degradation. Therefore, the compounds of the present disclosure may be effectively utilized for preventing or treating PLK1-related diseases.
    Type: Application
    Filed: August 10, 2022
    Publication date: March 27, 2025
    Applicant: UPPTHERA, INC.
    Inventors: Soo Hee Ryu, Im Suk Min, Han Kyu Lee, Seong Hoon Kim, Hye Guk Ryu, Keum Young Kang, Sang Youn Kim, So Hyun Chung, Jun Kyu Lee, Gibbeum Lee
  • RUBBER FORMULATIONS COMPRISING A STATISTICAL COPOLYMER COMPRISING VINYLBENZOCYCLOBUTANE
    Publication number: 20250101208
    Abstract: Embodiments of the present disclosure are directed to rubber formulations, wherein the formulations include a statistical copolymer. The statistical copolymer includes a polymerized, crosslinkable e reaction product derived from a conjugated diene monomer and vinylbenzocyclobutane. The rubber formulation is substantially free of traditional rubber curatives.
    Type: Application
    Filed: September 26, 2024
    Publication date: March 27, 2025
    Applicants: Bridgestone Corporation, Bridgestone Americas Tire Operations, LLC
    Inventors: Terrence Eugene Hogan, Walter Anthony Salamant
  • Functionalized Allopurinol Derivatives for Treatment of Alzheimer’s Disease
    Publication number: 20250101026
    Abstract: Provided herein are compounds having a structure of Formula I, Formula II, or Table 1 as disclosed herein and methods of using the disclosed compounds to inhibit a beta amyloid (A?)-amyloid-binding alcohol dehydrogenase (ABAD) protein-protein interaction, such as to inhibit beta amyloid (A?)-amyloid-binding alcohol dehydrogenase (ABAD) binding. For example, the compounds of Formula I, Formula II, and Table 1 as disclosed herein are useful for methods of treating diseases and disorders including, without limitation, Alzheimer's disease, Parkinson's disease, motor neuron disease, or spinal muscular atrophy.
    Type: Application
    Filed: January 25, 2023
    Publication date: March 27, 2025
    Inventors: Paul Trippier, Ahmed Morsy, Krishnaiah Maddeboina
  • RESIN COMPOSITION, MOLDED BODY, LAMINATE AND LAMINATED TUBE
    Publication number: 20250101209
    Abstract: A resin composition containing 40 to 90 mass % of a biomass-derived polyolefin (A) obtained by polymerizing a monomer component mainly containing a biomass-derived ethylene (x), 25 to 50 mass % of a linear low-density polyethylene (B) having a density of 0.90 to 0.93 g/cm3 and 1 to 10 mass % of a modified polyolefin (C) (provided that a sum of the (A), the (B) and the (C) is 100 mass %), in which a biomass content Pbio of the polyolefin (A) is 90% or more, and a biomass content Pbio of the resin composition is 50% or more, a formed body containing the same, a multilayer body, and a multilayer tube including the same. Pbio(%)=pMC/105.5×100 (in the equation, pMC indicates the content of radiocarbon 14C in the polyolefin (A) or the resin composition that is obtained in accordance with ASTM D6866.
    Type: Application
    Filed: March 24, 2023
    Publication date: March 27, 2025
    Applicant: MITSUI CHEMICALS, INC.
    Inventors: Takashi YAMASAKI, Akane SHIMANUKI, Yuhei IZAIKE, Yoshiyuki OGAWA, Takanori SASAKI
  • HETEROCYCLIC COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH
    Publication number: 20250101028
    Abstract: Provided herein are compounds having the following structure: wherein the substituents are as defined herein, compositions comprising an effective amount of a compound, and methods for modulating activity of KRAS G12D and/or G12V.
    Type: Application
    Filed: September 19, 2024
    Publication date: March 27, 2025
    Applicant: BeiGene, Ltd.
    Inventors: Chao YU, Jie CHEN, Hanzi SUN, Huaqing LIU, Ce WANG, Zhiwei WANG
  • MULTILAYER FILMS COMPRISING ETHYLENE-BASED POLYMERS
    Publication number: 20250101210
    Abstract: Provided are multilayer films including ethylene-based polymers. The multilayer films can be fully compatible with polyethylene recycling streams. The multilayer films include a first outer layer, a second outer layer, and a core, the core including a first core layer that includes an ethylene-propylene copolymer. The multilayer films of the present invention can exhibit improved, maintained, or desirable properties, such as high tear resistance, in comparison to existing multilayer film structures that are not fully compatible with polyethylene recycling streams.
    Type: Application
    Filed: January 25, 2023
    Publication date: March 27, 2025
    Inventors: Akanksha Garg, Shaun Parkinson, Jesus Nieto Palomo, Salma El Marrasse Zarioui, Frederik Ter Borg
  • ORGANIC COMPOUNDS
    Publication number: 20250101029
    Abstract: The invention relates to a particular enantiomer of a substituted heterocycle fused gamma-carboline, in free, solid, pharmaceutically acceptable salt and/or substantially pure form as described herein, pharmaceutical compositions thereof, and methods of use in the treatment of diseases involving the 5-HT2A receptor, and pathways involving the dopamine D1 and D2 receptor signaling system.
    Type: Application
    Filed: March 14, 2023
    Publication date: March 27, 2025
    Inventors: Peng LI, Robert E. DAVIS, Gretchen SNYDER, Allen A. FIENBERG
  • BIMODAL MEDIUM DENSITY POLYETHYLENE COMPOSITIONS SUITABLE FOR USE AS MICROIRRIGATION DRIP TAPES
    Publication number: 20250101212
    Abstract: Provided are bimodal medium density polyethylene compositions, and microirrigation drip tapes including the same. The bimodal medium density polyethylene compositions can be extruded at high lines speed while maintaining other desirable properties. The bimodal medium density polyethylene compositions include a high molecular weight (HMW) polyethylene component and a low molecular weight (LMW) polyethylene component. The bimodal medium density polyethylene composition has a density of from 0.937 to 0.946 g/cm3; a high load melt index (I21) from 7 to 20 g/10 min; a crossover G?=G? of from 30 to 50 kPa; a notched constant tensile load failure time at 30% yield stress, as measured according to ASTMD5397, of greater than 700 hours; and a strain hardening modulus of greater than 65 MPa.
    Type: Application
    Filed: February 9, 2023
    Publication date: March 27, 2025
    Inventors: Rujul M. Mehta, Alex Stolarz, Rachel C. Anderson, Chuan C. He, Mridula Kapur
  • COMPOUNDS THAT PARTICIPATE IN COOPERATIVE BINDING AND USES THEREOF
    Publication number: 20250101031
    Abstract: The invention features compounds (e.g., macrocyclic compounds) capable of modulating biological processes, for example through binding to a presenter protein (e.g., a member of the FKBP family, a member of the cyclophilin family, or PIN1) and a target protein such as CEP250. These compounds bind endogenous intracellular presenter proteins, such as the FKBPs or cyclophilins, and the resulting binary complexes selectively bind and modulate the activity of the target protein. Formation of a tripartite complex among the presenter protein, the compound, and the target protein is driven by both protein-compound and protein-protein interactions, and both are required for modulation of target protein activity.
    Type: Application
    Filed: April 18, 2024
    Publication date: March 27, 2025
    Inventors: Gregory Lawrence VERDINE, Brian Roger Bowman, Mathew Edward Sowa, Joshua Alan Van Dyke Blodgett, Keith Earl Robison, Dylan Talbot Stiles, Jay Paul Morgenstern, Sharon Ann Townson, Uddhav Kumar Shigdel
  • POLYETHYLENE BLEND FOR A FILM LAYER
    Publication number: 20250101213
    Abstract: Disclosed is a polyethylene blend of a specific multimodal metallocene catalysed linear low density polyethylene (mLLDPE) and a low density polyethylene (LDPE), which provides films with well-balanced properties, especially high dart drop (impact strength), low haze and low sealing initiation temperature.
    Type: Application
    Filed: January 24, 2023
    Publication date: March 27, 2025
    Applicant: BOREALIS AG
    Inventors: Jingbo WANG, Friedrich BERGER, Jani AHO
  • EXATECAN DERIVATIVES AND ANTIBODY-DRUG CONJUGATES THEREOF
    Publication number: 20250101032
    Abstract: Disclosed herein, in part, are novel exatecan derivatives with novel chemical linkers that include cathepsin B cleavable moieties, and conjugated to targeting antibodies.
    Type: Application
    Filed: May 6, 2022
    Publication date: March 27, 2025
    Inventors: Marija Vrljic, Peter Strop, Janica Cheuk-ying Wong, Jaume Pons
  • ARTICLES COMPRISING ETHYLENE-BASED POLYMER, POLYOLEFIN, SILANE CROSSLINKER, AND METALLIC STEARATE CATALYST
    Publication number: 20250101216
    Abstract: Embodiments of the present disclosure are directed to articles comprising a crosslinked reaction product of ethyl-ene-based polymer, polyolefin; silane crosslinker; and 1 to 5 weight percent (wt %) of a metallic stearate catalyst. The ethylene-based polymer is silane grafted. The grafted silane enables at least one intramolecular silane crosslinking of the ethylene-based polymer and intermolecular silane crosslinking of the ethylene-based polymer and the polyolefin.
    Type: Application
    Filed: December 22, 2022
    Publication date: March 27, 2025
    Applicant: Avient Corporation
    Inventors: Shu LIU, Liang XU, Yannan DUAN
  • NEW COMPOUNDS AND METHODS OF THEIR MANUFACTURING
    Publication number: 20250101033
    Abstract: The present document is directed to methods for producing therapeutically active limonoids as well as new limonoid-type compounds.
    Type: Application
    Filed: October 23, 2024
    Publication date: March 27, 2025
    Inventors: Jacob WESTMAN, Catarina MALMBERG
  • TWO-PART THERMALLY CONDUCTIVE RESIN COMPOSITION AND CURED PRODUCT
    Publication number: 20250101219
    Abstract: A two-part thermally conductive resin composition can be cured at normal temperature. A cured product has a sufficient resin elongation percentage. A two-part thermally conductive resin composition comprising a component (A) to a component (F): component (A): an epoxy resin (excluding epoxy resins having a (meth) acrylic-based polymer skeleton); component (B): a metal catalyst; component (C): an acrylic-based polymer and/or a polyether polyol (excluding component (D)); component (D): a crosslinkable silyl-containing organic polymer; component (E): an epoxy curing agent; and component (F): a heat dissipating filler.
    Type: Application
    Filed: January 26, 2023
    Publication date: March 27, 2025
    Inventors: Haruka HANOCHI, Takahito KOSAKA, Yosuke WATANABE