Abstract: A process for recovering and reusing a solvent and optical isomers, characterized by using a simulated moving packed bed which comprises an inlet for an eluent, an outlet for an extract containing an optical isomer strongly adsorbable on the packing, an inlet for a liquid containing an optical isomer mixture and an outlet for a raffinate containing an optical isomer weakly adsorbable on the packing in this order in a packed bed column containing packings for optical resolution and arranged in a solvent circulation passage, and in which the inlets and the outlets are intermittently and successively moved in the direction of liquid flow in the packed bed; recovering the solvent and the optical isomer(s) from the resultant extract and/or raffinate; returning the recovered solvent into the solvent circulation passage; or when the solvent is not recovered, heating the extract or raffinate to racemize an undesired optical isomer and reusing the resultant solution containing a racemic modification for the separation

Abstract: Process for the stereospecific synthesis of leukotriene B.sub.4 (LTB.sub.4) of 6Z, 8E, 10E configuration of formula ##STR1## in which a dibenzoate triether is prepared which is subjected to a reductive elimination according to the diagram ##STR2## so as to obtain a triether which is converted in order to obtain the leukotriene B.sub.4.

Abstract: Novel 1,4 and 1,2-diaminocyclohexane platinum IV complexes have been synthesized that show activity in vivo against tumor models resistant to cis-platin and tetraplatin. The novel complexes include the chloro, acetate, trifluoroacetate, propionate, butyrate, pentanoate, hexanoate and heptanoate as leaving ligands and 1,4 or 1,2-DACH-amine ligands. The complexes showed good in vitro cytotoxic activity against murine leukemia L1210/0, L1210/DDP and L1210/DACH. High in vivo activity was shown against L1210 leukemia cells and against cis-platin resistant L1210/DDP. Excellent antitumor activity against M5076 was also exhibited by the new complexes. Additionally, the platinum complexes did not elicit any indication of nephrotoxicity in the in vivo tests.

Abstract: A novel family of chemical compounds derived from fatty compounds has two branches of two carbon atoms on the linear chain and general formula C.sub.21 H.sub.39 COOR where R represents a hydrogen atom, a lower alkyl radical or a glyceryl radical. Particular compounds for consideration have the following formulae:(C.sub.2 H.sub.5).sub.2 C.sub.17 H.sub.29 COOR (I)(C.sub.2 H.sub.5)(C.sub.2 H.sub.4)C.sub.17 H.sub.30 COOR (II)and(C.sub.2 H.sub.5)(C.sub.2 H.sub.3)C.sub.17 H.sub.31 COOR (III)also compounds with the following formulae derived from partial or total hydrogenation of the above:(C.sub.2 H.sub.5).sub.2 C.sub.17 H.sub.31 COOR (IV)(C.sub.2 h.sub.5)(C.sub.2 h.sub.4)C.sub.17 H.sub.32 COOR (V)andti (C.sub.2 H.sub.5).sub.2 C.sub.17 H.sub.33 COOR (VI)Compounds with formulae (I), (II) and (III) may be produced by addition of ethylene to compositions comprising mainly diunsaturated C.sub.

Abstract: The present invention is directed to a process for preparing formoterol and related compounds and derivatives thereof and their pharmacologically and pharmaceutically acceptable fumarate salts and/or solvates. The present invention is also directed to certain formoterol related compounds per se.

Abstract: A process for recovering and reusing a solvent and optical isomers characterized by using a simulated moving packed bed which comprises an inlet for an eluent, an outlet for an extract containing an optical isomer strongly adsorbable on the packing, an inlet for a liquid containing an optical isomer mixture and an outlet for a raffinate containing an optical isomer weakly adsorbable on the packing in this order in a packed bed column containing packings for optical resolution and arranged in a solvent circulation passage, and in which the inlets and the outlets are intermittently and successively moved in the direction of liquid flow in the packed bed; recovering the solvent and the optical isomer(s) from the resultant extract and/or raffinate; returning the recovered solvent into the solvent circulation passage; or when the solvent is not recovered, heating the extract or raffinate to racemize an undesired optical isomer and reusing the resultant solution containing a racemic modification for the separation

Abstract: This invention describes a method for the treatment of a patient afflicted with a hyperproliferative disorder which comprises administering to a patient a effective amount of a compound which is an analogue of nicotinic acid and inhibits nicotinic acid metabolism in vitro in human platelets. Additionally, a method for determining the effectiveness of various compounds in treating a hyperproliferative disorder is described.

Abstract: A process is provided for making bulk calcium magnesium acetate in a substantially pure crystalline form. The crystalline CMA contains less than about 0.5% of water soluble impurities.

Abstract: Caged carboxyl compounds in which a 2-alkoxy-5-nitrophenyl photosensitive group blocks a carboxyl function are disclosed. Preferably the compounds are neuroactive amino acids. The compounds are photolyzable by laser pulses at wavelengths above about nm within about 3 .mu.s and provide a product quantum yield of greater than about 0.2.

Abstract: Propylene glycol monomethyl ether butyrates and their isomers are obtained by the esterification of propylene glycol monomethyl ether or its isomer with iso-butyric or n-butyric acid at an elevated temperature above 80.degree. C. in the presence of acidic catalyst and azeotropic agent. These compounds are rectified for removing acid residue and moisture in order to yield the desirable product having high purity.

Abstract: A poly(methylene oxalate) polymer [poly(oxy(1,2-dioxo-1,2-ethanediyl)oxymethylene)], a bis(tetrabutylammonium)oxalate salt, methods of synthesis thereof and methods of use. Poly(methylene oxalate) is insoluble in all common organic solvents, does not melt and is resistant to fire. Applications are as a light-weight material for use at high temperatures, e.g. as a structural material in aircraft and space vehicles, as a binder for brake systems, and as an insulator for microelectronic components.

Abstract: The present invention relates to an improved method for the preparation of iodonium salts. More specifically, the present invention relates to an improved method for the production of symmetric or asymmetric diaryliodonium triflate (trifluoromethane sulfonate) salts. The diaryliodonium salts of the present invention are useful as photoacid catalysts for use in acid-sensitive polymerization and in curing systems such as radiation curable release coating compositions.

Abstract: This specification provides a polymeric material useful for manufacturing contact lenses having improved oxygen permeability. The contact lenses prepared from the polymeric material of the invention show improved hydrophilicity and enhanced oxygen permeability as compared with that made of the conventional fluoroalkyl-containing polymeric materials.

Abstract: The present specification relates to an industrially advantageous process for producing vitamin A derivatives which are useful as medicaments, feed additives, food additives and the like. The process provides vitamin A derivatives, particularly all-trans vitamin A derivatives in high yield and purity.

Abstract: The present invention is directed to compounds which inhibit farnesyl-protein transferase (FPTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting famesyl-protein transferase and the famesylation of the oncogene protein Ras.

Abstract: Phenoxyphenylacetic acids and derivatives of general structural formula I ##STR1## have endothelin antagonist activity and are therefore useful in treating cardiovascular disorders, such as hypertension, postischemic renal failure, vasospasm, cerebral and cardiac ischemia, myocardial infarction, inflammatory diseases, Raynaud's disease, and endotoxic shock, and asthma.

Abstract: Preparation of an aliphatic carboxylic acid having (n+1) carbon atoms, where n is an integer up to 6, may be achieved by contacting an aliphatic alcohol having n carbon atoms or a reactive derivative thereof with carbon monoxide, in the presence of a copper, nickel, iridium, rhodium or cobalt loaded mordenite zeolite catalyst, at elevated temperature and at a pressure in the range 15 to 200 bars.

Abstract: A compound of the formula I ##STR1## in which D is a diazo component,K is an aromatic group of formula a, b or c, ##STR2## Y is C.sub.2-3 alkylene and the remaining symbols are as defined in the specification. These compounds are useful for dyeing or printing textile substrates based on synthetic or semisynthetic, hydrophobic, high molecular weight organic materials. Preferably, the textile substrate is made from a linear aromatic polyester, cellulose 21/2 acetate or cellulose tri-acetate. The dyeings and prints obtained show good all round fastness properties such as good thermomigration properties, lightfastness, thermofixation, blistering properties as well as good wet fastness properties, especially after thermal fixation.

Abstract: Novel parenteral nutrient compositions are disclosed. These compositions are sterile aqueous solutions containing an effective amount of at least one glycerol bisacetoacetate of the formula: ##STR1## wherein one R group is hydrogen, and two R groups are --COCH.sub.2 COCH.sub.3). These compositions are useful as a substitute for glucose in intravenous feeding.

Abstract: Polymethylaluminoxane compositions having increased solution stability in organic solvent and, in some cases, increased polymerization activity, which comprise moieties derived from an organic compound containing an electron-rich heteroatom (e.g., from Group V and/or Group VI of the Periodic Table) and a hydrocarbyl moiety. These compositions can be formed by reaction of trimethylaluminum, the organic compound, and water. They can also be formed by reaction of pre-formed polymethylaluminoxane the organic compound, which can be a hydrocarbyl group-containing compound containing an electron-rich heteroatom (e.g., oxygen, nitrogen, or sulfur), either with or without an active hydrogen atom connected to the heteroatom. The organic compound, in some embodiments, has also been found to be effective in increasing the catalytic activity of modified polymethylaluminoxane which, in addition to methyl, contain C.sub.2 and higher alkyl groups for enhanced solution stability.