Abstract: Pyrimidine 3-oxide derivatives and their use for the treatment of hair loss. The compositions contain in a physiologically acceptable medium at least one compound corresponding to the formula (I): ##STR1## in which: R.sub.1 denotes a methyl or NHR.sub.4 group in which R.sub.4 denotes a C.sub.1 -C.sub.4 alkyl group or hydrogen;R.sub.2 denotes hydrogen or a group NHR.sub.4 in which R.sub.4 has the same meaning as above; R.sub.2 may also denote methyl when R.sub.1 denotes methyl; when R.sub.1 denotes NH.sub.2, R.sub.2 cannot be hydrogen;R.sub.3 may denote a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group which may optionally carry;a group OR.sub.5 in which R.sub.5 denotes a C.sub.1 -C.sub.4 alkyl group,a benzene nucleus which is optionally substituted by one or more C.sub.1 -C.sub.4 alkoxy groups;R.sub.3 may also denote a halogen atom or a nitro or amino group;and the physiologically acceptable acid addition salts.

Abstract: A method of preparing methacrolein and/or methacrylic acid by catalytic gas phase oxidation of isobutane in the presence of a catalyst, wherein said catalyst is a catalyst containing divanadyl pyrophosphate and represented by general formula (1)P.sub.a V.sub.b X.sub.c Y.sub.d Z.sub.e O.sub.x (1)wherein P, V, and O represent phosphorus, vanadium and oxygen, respectively; X represents at least one element selected from the group consisting of cobalt and nickel; Y represents at least one element selected from the group consisting of niobium, tantalum, manganese, iron, copper, zinc, lanthanum, neodymium, samarium, cerium, zirconium, chromium, magnesium, tungsten, tin, hafnium, uranium, indium, cadmium, molybdenum, antimony, bismuth, rhodium, silver and sulfur; Z represents at least one element selected from the group consisting of potassium, rubidium, cesium and thallium; a, b, c, d, e, and x represent atomic ratios, respectively, provided that when a is 1, b is 0.2 to 2, c is 0.

Abstract: Benzylimidazole derivatives are described as anxiolytic agents.

Abstract: A Process for producing N-alkyl iodopropargyl carbamate comprising:A. reacting a dialkyl(C.sub.1 -C.sub.3) carbonate with propargyl alcohol in the presence of a first catalyst under conditions to produce dipropargyl carbonate;B. reacting said dipropargyl carbonate with an alkyl(C.sub.1 -C.sub.6)amine, optionally in the presence of a second catalyst, to produce N-alkyl(C.sub.1 -C.sub.6) propargyl carbamate;C. reacting said N-alkyl(C.sub.1 -C.sub.6) propargyl carbamate with an iodinating agent to produce N-alkyl(C.sub.1 -C.sub.6) iodopropargyl carbamate is disclosed.

Abstract: Oxyalkyne compounds corresponding to the formula I ##STR1## in which the substituent Y in the meta- or para-position is R.sup.1 represents CH.sub.3 or NH.sub.2, R.sup.2 represents H or CH.sub.3, R.sup.3 represents H, C.sub.1-3 -alkyl or COCH.sub.3, and Ar represents an aromatic residue selected from the group ##STR2## with the proviso that the substituents R.sup.4, R.sup.5 and R.sup.6 are the same or different and each substituent represents H, F, Cl, Br, C.sub.1-6 -alkyl, CF.sub.3 or C.sub.1-6 -alkoxy, and R.sup.7 represents H, F, Cl, Br, C.sub.1-3 -alkyl or CF.sub.3,in the form of their racemates or mixtures of diastereoisomers or in optically active form, which are suitable active ingredients in pharmaceutical compositions.

Abstract: An alkali metal sulfonate-substituted binaphthyl-phosphine transition metal complex is disclosed, which is represented by formula (I)[M(X).sub.n (Q)(SO.sub.3 A--BINAP)]Y (I)wherein M represents a transition metal atom; SO.sub.3 A--BINAP represents a tertiary phosphine represented by formula (II) ##STR1## in which A represents an alkali metal atom; X represents a chlorine atom, a bromine atom, or an iodine atom;when n is 1, M represents ruthenium, Q represents benzene or p-cymene, and Y represents a chlorine atom, a bromine atom, or an iodine atom;when n is 0 and M is iridium or rhodium, Q represents 1,5-cyclo-octadiene or norbornadiene, and Y represents ClO.sub.4, PF.sub.6 or BF.sub.4 ; and when n is 0 and M is palladium, Q represents .pi.-allyl, and Y represents ClO.sub.4, PF.sub.6, or BF.sub.4.

Abstract: Novel tert-alkyl carbamate silicon compounds are provided which are useful as coupling agents. The compounds have the formulas: ##STR1## wherein the R groups can represent various hydrocarbon and other groups, n has a value of 1 to 10, b has a value of from 2 to 5 and a has a value of 1, 2 or 3.Processes are also provided for the preparation of the carbamate compounds and their use as coupling agents.

Abstract: The present invention relates to a process for the preparation of C.sub.5 -C.sub.8 aliphatic dibasic acids through oxidation of corresponding saturated cycloaliphatic hydrocarbons by(1) reacting, at a cycloaliphatic hydrocarbon conversion level of between about 7% and about 30%,(a) at least one saturated cycloaliphatic hydrocarbon having from 5 to 8 ring carbon atoms in the liquid phase and(b) an excess of oxygen gas or an oxygen-containing gas mixturein the presence of(c) less than 1.5 moles of a solvent per mole of cycloaliphatic hydrocarbon (a), wherein said solvent comprises an organic acid containing only primary and/or secondary hydrogen atoms and(d) at least about 0.002 mole per 1000 grams of reaction mixture of a polyvalent heavy metal catalyst; and(2) isolating the C.sub.5 -C.sub.8 aliphatic dibasic acid.

Abstract: By reacting 1,3-propanediol with oxygen or an oxygen-containing gas in an aqueous alkaline solution in the presence of a palladium containing catalyst substrate, alkaline salts of 3-hydroxypropionic acid are produced in good yield when the catalyst is used in an amount that corresponds to 0.1 to 3.0% by weight of palladium, based on the 1,3-propanediol.

Abstract: Propylene glycol monomethyl ether propionate compounds are obtained by the esterification of propylene glycol monomethyl ether with propionic acid at an elevated temperature above 80.degree. C. in the presence of acidic catalyst and azeotropic agent. The compounds are rectified for removing acid residue and moisture in order to yield the desirable product having high purity.

Abstract: Water-soluble complexes having the formula: ##STR1## and stereoisomers thereof, where Z.sup.1 and Z.sup.2 are halogens, and X.sup.1 and X.sup.2 are selected from the group consisting of sulfate, phosphate, nitrate, and monocarboxylate, or are jointly dicarboxylate, have been found to have desirable antitumor activity, as well as relatively low levels of toxicity.

Abstract: Disclosed is a process for introducing a carboxyl group to an aromatic carboxylic acid or a derivative thereof, which comprises reacting a starting aromatic carboxylic acid, such as a benzoic acid, a biphenylcarboxylic acid, a naphthalenecarboxylic acid, a diphenylcarboxylic acid, or a derivative thereof, with a carbon tetrahalide in the presence of a cyclodextrin and an alkali metal hydroxide, thereby introducing a carboxyl group to the aromatic ring of the starting aromatic carboxylic acid or the derivative thereof in substitution for a hydrogen atom bonded thereto. By the process of the present invention, a desired aromatic polycarboxylic acid or a derivative thereof can be easily obtained with high selectivity.

Abstract: The present invention provides a process for producing a halomethyl ester of an aliphatic carboxylic acid in which a metal salt of an aliphatic carboxylic acid is reacted with a dihalomethane in the presence of a phase transfer catalyst, whereby the efficient production of a halomethyl ester of an aliphatic carboxylic acid has been made possible without the formation of a halomethyl ether as a by-product. The bis compound bis[aliphatic carbonyloxy)methane], which is obtained as a by-product, is hydrolyzed to enable the quantitative recovery of an aliphatic carboxylic acid and its reuse. Thus, the present process is preferable as a process for industrial production of a halomethyl ester of an aliphatic carboxylic acid.

Abstract: A process is disclosed for the preparation of pure ammonium thioglycolate from thioglycolic acid contaminated with the isopropyl ester of thioglycolic acid wherein the contaminated acid is reacted with aqueous ammonia or ammonium hydroxide at a pH of at least 6.5 to about 9.0 at elevated temperature.

Abstract: Multistep process for the preparation of alkyl mono and diisocyanates consisting in reacting the corresponding aliphatic amine or diamine with dimethylcarbonate and, substantially, in partially vaporizing and converting the urethane thus formed in an evaporator to subsequently terminate the cracking in a II.degree. reactor, and finally subjecting the cracking product to fractional distillation at reduced pressure, recycling the unconverted part to the partial vaporization step.

Abstract: A novel process for the preparation of isomers or mixtures of isomers of compounds of the formula ##STR1## and novel intermediates therefore.

Abstract: Adipic acid is selectively prepared via hydrocarboxylation of pentenoic acids, by reacting water and carbon monoxide with at least one pentenoic acid, in the presence of a catalytically effective amount of a rhodium-based catalyst and at least one iodinated promoter therefor, at a temperature ranging from 100.degree. to 240.degree. C. and a pressure greater than atmospheric, and wherein (a) such reaction is carried out in the absence of a third reaction solvent and (b) the carbon monoxide partial pressure, measured at 25.degree. C., is less than or equal to 20 bar.

Abstract: Silicon boron nitride ceramics are produced from polyborosilizanes obtained from polymerized Cl.sub.3 Si--NH--BClX wherein X is --Cl or --NH--Si--Cl.sub.3.

Abstract: Dicarboxylic acids, e.g., adipic acid, are prepared by reactively distilling and hydrolyzing admixture of a C.sub.1 -C.sub.4 alkyl aliphatic dicarboxylate and water, e.g., dimethyl adipate/water admixture, in liquid phase, in a distillation column, the lower end of which distillation column being charged with a gel of a crosslinked styrene/divinylbenzene resin bearing sulfonic acid substituents, the amount by weight of divinylbenzene comprising such resin ranging from 1% to 12% based on the total weight thereof and such resin having an exchange capacity of from 3 to 6.5 milliequivalents H.sup.+ /gram of dry resin, and including introducing the dicarboxylate/water admixture into the middle region of the column, withdrawing dicarboxylic acid from the base thereof and overhead distilling the alcohol of hydrolysis.

Abstract: A process for the separation of amino acids from aqueous solutions by adsorption on zeolites of different types. It is unnecessary to separate the biomass prior to the treatment.