Abstract: Method of controlling the host defense system in a body by internally administering coenzymes Q or carotenoids, and structurally related compounds at appropriate dosage schedules.

Abstract: A lectin is covalently bonded to an immunological conjugate such as an antibody-antigen or its equivalent. Then, the lectin-conjugate is isolated from the reaction product mixture by one of a number of alternative techniques involving one or more of the following types of reaction; (1) reversible reaction of the lectin with an insolubilized sugar to isolate lectin from the remainder of the mixture, (2) reaction of one immunological component (e.g., antibody) bonded to the lectin with an insolubilized corresponding component (e.g., antigen) to separate the antibody components from the remainder of the reaction mixture, and (3) filtration of the reaction components to separate on the basis of product molecular weight, size and/or shape of the components.

Abstract: This disclosure describes a method of treating hyperlipidemia and atherosclerotic lesions with 4-(monoalkylamino)benzoic acid amides and compositions therefor.

Abstract: This invention relates to tolerogenic conjugates, suitable for use in suppressing the formation of reaginic antibodies in a host, of haptenic determinants, in particular the benzylpenicilloyl (BPO) group and 2,4-dinitrophenyl (DNP) group, with water-soluble, nonimmunogenic polymers, i.e. polyvinyl alcohols (PVA). The invention also comprises a method for the preparation of the conjugate and a method of suppressing the formation of these antibodies in a mammal sensitive to penicillin.

Abstract: The method of producing clinical assays for use of monoclonal antibodies in the diagnosis of Herpes simplex virus (HSV) infections and the differentiation of Herpes Simplex virus types 1 and 2 as a diagnostic kit for differentiating HSV-1 and HSV-2 utilizing clone 1D4 against HSV-1 and clone 3E1 against HSV-2.

Abstract: A process for producing an antibiotic, which comprises cultivating an antibiotic KA-6606-producing strain of an genus Saccharopolyspora in a nutrient culture medium, isolating the antibiotic KA-6606-containing substance from the culture broth, and separating from the resulting antibiotic KA-6606-containing substance at least one antibiotic selected from the group consisting of antibiotic KA-6606 VII, KA-6606 VIII, KA-6606 IX, KIA-6606 X, KA-6606 XI, KA-6606 XII, KA-6606 XIII, KA-6606 XIV, KA-6606 XV, KIA-6606 XVI and KA-6606 XVII; and novel antibiotics KA-6606 XII, XIII and XV to XVII.

Abstract: A method for the detection of malignant leukocytic cells which comprises:contacting a fluid containing malignant leukocytic cells with a merocyanine dye of the formula: ##STR1## wherein n=1-5; X=0 or S; R.sub.1 and R.sub.2 are the same or different C.sub.2 -C.sub.5 alkyl groups:wherein said dye is incorporated into said cells; separating the cells from the incubation mixture; and detecting said dyed cells. Fluorescence or radioactivity detection methods are preferred detecting means.

Abstract: Pharmaceutical formulations comprising an imidazole (or pharmaceutically acceptable salt thereof) of formula: ##STR1## wherein (i) A is an aliphatic hydrocarbon residue of from 1 to 4 carbon atoms and R is a naphthyl, tetrahydronaphthyl, heterocyclyl, arylthio, arylalkylthio, aryloxy, arylalkyloxy, arylhydroxymethylene, arylcarbonyl, arylalkylcarbonyl, alkyloxy, alkylthio or a substituted cycloalkyl or cycloalkenyl group or(ii) A' is an --SO.sub.2 -- group and R is aryl or heterocyclyl or(iii) A is a chemical bond and R is a heterocyclyl.Some of these imidazoles and salts are novel.Methods of preparing the imidazoles are disclosed. The imidazoles and their salts are useful in the treatment or prophylaxis of thrombo-embolic conditions, shock and angina pectoris.

Abstract: Novel oligopeptides are provided having serologic activity for the a determinant of hepatitis B virus surface antigen. Included in the oligopeptide chain are a sequence of at least two cysteines and a lysine in proximity to the cysteines. The oligopeptides can find use in immunoassays, the formulation of vaccines, and the production of antisera.

Abstract: A water-soluble non-immunogenic carrier, namely carboxymethyl cellulose, is provided which, in attachment to allergens or other haptens, is capable of inducing an immunological tolerance in an individual of a mammalian species to the allergen or hapten. The allergen or hapten is attached to each of a plurality of the carboxyl groups of carboxymethyl cellulose. Tolerance has been induced in mice to three particular haptens, namely 2,4-dinitrophenyl, penicillin G and fluorescein in the specific embodiments of the present invention.

Abstract: The invention comprises preparations for the treatment of neoplasms, the methods of treatment of neoplasms using such preparations, and processes for preparing such preparations, including the step of selective enzymatic degradation of the nuclei of cancer cells.The invention further comprises the method of treating patients suffering from neoplasms with immunomodulating agents obtained by isolating the genetically active components of cancer cell nuclei obtained from cancer tissue, subsequently recombining them by specific hybridization steps to prepare a vaccine therefrom, and intravenously, intraperitoneally and/or intramuscularly administering the resulting vaccine product to patients.

Abstract: The present invention relates to a pharmaceutical composition containing (1) 6,8-dimethyl-7-ethoxycarbonyl-4-hydroxymethyl-1-phthalazone, (2) a water-soluble cellulose ether alone or together with a polyhydric alcohol or a pharmaceutical carrier. The pharmaceutical composition is useful for preventing and/or treating cerebral blood vessel disorders, peripheral blood vessel disorders and nerval diseases.

Abstract: The treatment of mammals with organo amine salts of sulfites and bisulfites suffering from hypertension is described.

Abstract: Extended-life aqueous tissue fixative compositions or solutions are provided for use in histopathology work and the like. The compositions include glutaraldehyde at controlled pH, a boric acidtetraborate buffer, buffer stabilizer and complexing agent. The compositions, which also may include a compatible surfactant, and their method of application enable efficient fixing such that the treated tissues have low artifactual color and good texture and may readily be sectioned and accurately stained.

Abstract: The treatment of mammals with addition products of a carbonyl group containing compound with bisulfites to improve a mammal (including man) suffering from hypertension is described.

Abstract: A novel method of diagnosis of atherosclerosis comprises comparing the migration of endothelial cells or of cells of endothelium-like morphology in vitro, in the presence of serum from the person being examined, with the migration of identical cells in the presence of serum from healthy persons or of other standard sera, and interpreting a reduced migration in the presence of serum of the person being examined as being an indication of the possible existance of atherosclerosis in this person. The cell migration is measured for example on monolayer cell cultures of pig aorta endothelial cells or of Balb/c 3T3-A31 cells, in which cultures a portion of the cellular layer has been removed. An outfit for carrying out the method contains the materials and devices necessary for the purpose.

Abstract: Erythrocytes are coated with specific hemagglutinating virus antigen and then treated to produce a stabilized, antigen coated erythrocyte preparation which is used in the determination of antibody in biological fluids.

Abstract: Certain salts of carbonyl sulfur dioxide adducts are found to demonstrate anticoagulant and/or venous antithrombotic activity.

Abstract: The treatment of mammals with organic quaternary ammonium alkali metals, alkaline sulfites and bisulfites suffering from hypertension is described.

Abstract: Solutions of sulfur dioxide are found to demonstrate anticoagulant and antithrombotic activity when used in pharmaceutically effective amounts.