Patents Examined by A. M. Davenport
  • Composition and methods for the inhibition of phagocytes
    Patent number: 6017883
    Abstract: The present invention relates to the identification, purification and characterization of novel factors which inhibit phagocyte activation, such as inhibiting polymorphonuclear neutrophil chemotaxis, degranulation and superoxide production. Disclosed are natural peptides purified from the bronchial environment and a variety synthetic peptides and analogues designed to have enhanced or longer-lasting phagocyte-inhibiting activity. The peptides and compositions of the present invention are contemplated for use in modulating inflammatory responses in a number of clinical settings, such as in the treatment of asthma, bronchitis, acute lung injury, rheumatoid arthritis, psoriasis, dermatitis and inflammatory bowel disease, and for use as anti-proliferative agents such as in the treatment of cancer.
    Type: Grant
    Filed: March 3, 1998
    Date of Patent: January 25, 2000
    Assignee: Research Corporation Technologies, Inc.
    Inventor: J. Allen D. Cooper, Jr.
  • Non-irritating cosmetic and pharmaceutical compositions
    Patent number: 6017549
    Abstract: The present invention relates to a cosmetic or pharmaceutical emulsion for topical application to the skin comprising an irritating agent and at least one non-disruptive emulsifier. In a preferred embodiment the irritating agent is a retinoid. The invention also provides a method for decreasing the irritation on the skin caused by an irritating active agent in a topical cosmetic or pharmaceutical emulsion which comprises employing as an emulsifier at least one of an alkyl polyoside, a grafted water soluble protein on a hydrophobic backbone, and lecithin.
    Type: Grant
    Filed: September 30, 1997
    Date of Patent: January 25, 2000
    Assignee: E-L Management Corp.
    Inventors: E. Althea Knight, Daniel H. Maes, Carmen Castillo-Bucci, Jules Zecchino
  • Use of heme-peptides to prevent or retard disease associated with oxidative stress
    Patent number: 6013623
    Abstract: This invention provides a method for treating a condition associated with oxidative stress in a subject which comprises administering to the subject an amount of a heme-peptide effective to treat the condition associated with oxidative stress in the subject. The subject may be a mammal. The mammal may be a human being. The condition associated with oxidative stress may be an inflammatory condition, an allergic condition or an auto-immune condition.
    Type: Grant
    Filed: February 27, 1997
    Date of Patent: January 11, 2000
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Abraham Spector, Wanchao Ma, Ren-Rong Wang
  • Organic compounds
    Patent number: 6013627
    Abstract: Cyclopeptolides of formula I ##STR1## wherein A, B, R, Leu, Leu, C, X and Y are as defined, are inhibitors of adhesion molecule expression and are thus useful for treatment of inflammatory and other diseases which involve increased levels of adhesion molecule expression.
    Type: Grant
    Filed: January 24, 1997
    Date of Patent: January 11, 2000
    Assignee: Novartis AG
    Inventors: Michael Morris Dreyfuss, Carolyn Ann Foster, Hans-Ulrich Naegeli, Berndt Oberhauser
  • Method for treating conditions of the eye using polypeptides
    Patent number: 6013628
    Abstract: A method is provided for treating diseases and conditions of the eye which include scarring and proliferation of fibroblasts. The invention includes a method for treating proliferative vitreoretinopathy. The invention also includes a method for treating glaucoma. One embodiment of the method includes administering to the eye an amount effective for treating such a condition of a polypeptide. The polypeptide includes a sequence of at least about 5 amino acids corresponding substantially to an amino acid sequence from within the 33 kD fragment of the A chain of fibronectin, within the G domain of the A chain of laminin, or within the NC1 domain of the .alpha.2 chain of type IV collagen. Another embodiment of the method, which includes administering to the eye an amount of conjugate including the polypeptide and a carrier molecule conjugate, is also disclosed.
    Type: Grant
    Filed: February 27, 1995
    Date of Patent: January 11, 2000
    Assignee: Regents of the University of Minnesota
    Inventors: Amy P. N. Skubitz, Leo T. Furcht, Mark Balles, Dale S. Gregerson, Anita Agarwal, Martha M. Wright, Shobana Murali
  • Compounds for control of appetite, blood pressure, cardiovascular response, libido, and circadian rhythm
    Patent number: 6013633
    Abstract: This invention relates generally to dipeptides and tripeptides and to methods for pharmaceutical treatment of mammals using analogs of such dipeptides and tripeptides. More specifically, the invention relates to tripeptides and their analogs, to pharmaceutical compositions containing such dipeptides and tripeptides and to methods of treatment of mammals using such dipeptides and tripeptides. In addition, the invention relates to methods of treatment of mammals using such dipeptides and tripeptides for control of appetite, blood pressure, cardiovascular response, libido, and circadian rhythm.
    Type: Grant
    Filed: August 7, 1997
    Date of Patent: January 11, 2000
    Assignee: University of Cincinnati
    Inventors: Ambikaipakan Balasubramanium, William T. Chance
  • Prevention of pregnancy miscarriages
    Patent number: 6011005
    Abstract: There is disclosed a method for helping to prevent miscarriages during pregnancy, comprising administering an effective amount of a fetuin polypeptide.
    Type: Grant
    Filed: September 18, 1997
    Date of Patent: January 4, 2000
    Assignee: The Picower institute for Medical Research
    Inventors: Kevin J. Tracey, Haichao Wang
  • Process for recovering growth factors, or a composition containing one or more growth factors, from milk or a milk derivative
    Patent number: 6010698
    Abstract: The invention relates to a process for recovering one or more growth factors from milk or a milk derivative, comprising adsorbing at least one growth factor from the milk or the milk derivative to a cation exchanger, followed by fractionated elution of the cation exchanger, whereby at least one fraction is obtained which is enriched in growth factors, followed by the further treatment of this fraction at a pH of at least 3.5 and not more than 4.5.
    Type: Grant
    Filed: March 24, 1998
    Date of Patent: January 4, 2000
    Assignee: Campina Melkunie B. V.
    Inventors: Klaas Daniel Kussendrager, Marinus Gerardus Cornelis Kivits, Hubert Karel Lemmen, Theodorus Johannes Antonia Maria van Kessel
  • Peptide T and related peptides in the treatment of inflammation, including multiple sclerosis
    Patent number: 6011014
    Abstract: A method of treating or preventing multiple sclerosis in a patients in need of such treatment by administering an effect amount of the peptide: I-A-B-C-D-E-F-G-H-II (General Formula) wherein A is Ala, Gly, Val, Ser, Thr or absent, B is Ala, Gly, Val, Ser, Thr or absent, C is Ser, Thr or absent, D is Ser, Thr, Asn, Glu, Arg, IIe, Leu or absent, E is Ser, Thr, Asp or absent, F is Thr, Ser, Asn, Glu, Lys, Trp or absent, G is tyr or absent; H is Thr, Arg, Gly, Met, Met(O), Gys, Thr, Gly or absent, I is Cys or absent, II is Cys, an amide group, substituted amide group, an ester group or absent.
    Type: Grant
    Filed: May 21, 1998
    Date of Patent: January 4, 2000
    Assignee: Advanced Immunit, Inc.
    Inventors: Anders Jorgen Andersen, Roger Aston, Peter Louis Carlen, Penelope Reed Doob, Douglas Kevin MacFadden, David James Phipps, Deborah Rathjen, Fred Widmer
  • Pharmaceutical compositions containing cyclosporin
    Patent number: 6008191
    Abstract: A novel homogenous alcohol free, free flowing, clear and transparent pharmaceutical composition containing Cyclosporin is disclosed. The amount of Cyclosporin is easily measurable at a wide range of temperature of 15.degree. to 45.degree. C. The composition comprises a Cyclosporin in a hydrophillic carrier medium comprising propylene glycol, a transesterification product of a natural vegetable oil triglyceride and a polyalkylene polyol--such as Apricot Kernel Oil Polyethylene glycol 6 esters--such as Labrafil M1944 and polyethylene hydrogenated castor oils--such as Cremophor RH 40 and Glycerol Triacetate or Triacetin.
    Type: Grant
    Filed: August 19, 1998
    Date of Patent: December 28, 1999
    Assignee: Panacea Biotec Limited
    Inventors: Amarjit Singh, Rajesh Jain
  • Nociceptin analogues
    Patent number: 5998375
    Abstract: The present invention relates to novel peptides, pharmaceutical compositions containing them, methods for preparing the compounds, use of the compounds for preparing medicaments for treating vasomotor disturbances, in particular the peripheral vasomotor effects known as hot flushes or hot flashes, and to a method of treating vasomotor disturbances.
    Type: Grant
    Filed: July 14, 1998
    Date of Patent: December 7, 1999
    Assignee: Novo Nordisk A/S
    Inventors: Henning Th.o slashed.gersen, Kjeld Madsen, Uffe Bang Olsen, Nils Langeland Johansen, Mark Scheideler
  • Derivatives of structurally modified VIP and pharmaceutical compositions containing them
    Patent number: 5998368
    Abstract: There are provided novel compounds for the treatment of male impotence. The compounds are derived from vasoactive intestinal peptide (VIP) in which the natural amino acid sequence is modified by replacement of any of the 5, 17 and 19 amino acid residues by other natural or non-natural amino acids, and they bear at least one terminal lipophilic group.The modified VIP sequences are prepared by conventional peptide chain assembling methods.The novel compounds and compositions containing them are suitable for transdermal application for treating male impotence.
    Type: Grant
    Filed: July 21, 1997
    Date of Patent: December 7, 1999
    Assignees: Yeda Research and Development Co. Ltd., Ramot University Authority for Applied Research and Industrial Development Ltd.
    Inventors: Illana Gozes, Matityahu Fridkin
  • Methods of treatment with novel antibiotic feglymycin
    Patent number: 5994307
    Abstract: This invention relates to the antibiotic feglymycin, as well as processes for its preparation and use. Feglymycin is represented by the structural formula (SEQ. ID. NO.
    Type: Grant
    Filed: December 2, 1998
    Date of Patent: November 30, 1999
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Laszlo Vertesy, Martin Knauf, Joachim Wink, Dieter Isert, Wilhelm Stahl, Gunther Riess, Jozsef Aszodi, Dominique Le Beller
  • Cell growth substrate polymer
    Patent number: 5994133
    Abstract: Cell growth substrate polymers are described which comprise a macromonomer of the formula (I): Q-(PFPE-L).sub.n-1 -PFPE-Q, wherein n is at least 1.0; each PFPE may be the same or different and is a perfluorinated polyether of the formula (II): --OCH.sub.2 CF.sub.2 O (CF.sub.2 CF.sub.2 O).sub.x (CF.sub.2 O).sub.y CF.sub.2 CH.sub.2 O--, wherein the CF.sub.2 CF.sub.2 O and CF.sub.2 O units may be randomly distributed or distributed as blocks throughout the chain and wherein x and y may be the same or different such that the molecular weight of the perfluoropolyether is in the range of from 242 to 4000, L is a difunctional linking group; and Q at each end of the macromonomer is the same or different and is a polymerizable group. The cell growth substrate polymers may be used in the production of comeal implants.
    Type: Grant
    Filed: January 6, 1998
    Date of Patent: November 30, 1999
    Assignees: Novartis AG, Commonwealth Scientific and Industrial Research Organisation
    Inventors: Gordon Francis Meijs, Bronwyn Glenice Laycock, Madeleine Clare Griffiths, Edith Cheong, John Gerard Steele, Graham Johnson
  • Method of treating inflammation
    Patent number: 5994305
    Abstract: A method of producing analgesia in nociceptive and neuropathic pain is disclosed. The method includes administering to a subject an omega conopeptide which is characterized by its ability to (a) inhibit electrically stimulated contraction of the guinea pig ileum, and (b) bind selectively to omega conopeptide MVIIA binding sites present in neuronal tissue. Also disclosed are novel omega conotoxin peptides effective in producing analgesia.
    Type: Grant
    Filed: August 21, 1998
    Date of Patent: November 30, 1999
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Alan Justice, Tejinder Singh, Kishor Chandra Gohil, Karen L. Valentino, George P. Miljanich
  • Use of protein S-100-b in medicines containing the protein S-100b
    Patent number: 5990080
    Abstract: The present invention concerns the use of the protein S-100b in medicines for the stimulation of growth and survival of damaged neurons. The invention includes as well a medicine containing the S-100b protein in an aqueous solution which may contain also other biocompatible substances.
    Type: Grant
    Filed: April 15, 1998
    Date of Patent: November 23, 1999
    Assignee: A+ Science Invest AB
    Inventor: Kenneth G. Haglid
  • Alpha-1 proteinase inhibitor binding peptides
    Patent number: 5985836
    Abstract: Peptides which bind to alpha-1 Proteinase inhibitor (AlPI) are disclosed. The peptides have an available AlPI binding domain which may be any of the following preferred sequences: Val Ile Trp Leu Val Arg, Ile Ile Trp Leu Tyr Lys, Arg Tyr Arg Ile Phe Ile, Arg Ala Phe Trp Tyr Ile, Arg Phe Ile Tyr Tyr Thr, Tyr Lys Phe Arg Phe Trp, Leu Ile Val His Arg Trp, Pro Tyr Trp Ile Val Arg, Ala Arg Trp Tyr Ile His, Gln Tyr His Phe Trp Tyr, Arg Leu Trp Arg Tyr Gly, Val Ile Tyr Leu Val Arg, Val Ile Phe Leu Val Arg, Lys Ile Phe Leu Val Arg, Arg Ile Phe Leu Val Arg, His Ile Phe Leu Val Arg, Arg Val Leu Phe Ile Val, or Arg Val Leu Phe Ile His (SEQ ID NOS: 1-8, 10, 11, 15, 36, 37, 45, 46, 47, 61, and 62 respectively). A method of using peptides having these available binding domains in an affinity chromatography process to purify AlPI is described.
    Type: Grant
    Filed: July 31, 1998
    Date of Patent: November 16, 1999
    Assignee: Bayer Corporation
    Inventors: Patrick D. Bastek, John M. Lang, George A. Baumbach, Ruben G. Carbonell
  • Desmopressin for nocturia, incontinence and enuresis
    Patent number: 5985835
    Abstract: A process for the manufacture of high purity desmopressin produced in single batches of substantial size and a method of treating nocturia, incontinence and enuresis with the high purity desmopressin produced therefrom.
    Type: Grant
    Filed: July 13, 1997
    Date of Patent: November 16, 1999
    Assignee: Ferring B.V.
    Inventors: Krister Larsson, Thomas Mellbrand, Birgitta Mornstam, Jan Roschester, Jan-Ake Skoldback, Ragner Asplund, Jens-Peter N.o slashed.rgaard
  • Method for the treatment of diarrheal disease and for eliminating particular bacterial populations from the colon
    Patent number: 5985823
    Abstract: The invention is directed to methods of treating diseases brought on by infection of the colon by C. difficile and also by colonization of vancomycin-resistant enterococci; the methods employ nisin and other lanthionine-containing bacteriocins (lanthocins) as active agents.
    Type: Grant
    Filed: October 14, 1997
    Date of Patent: November 16, 1999
    Assignee: Ambi Inc.
    Inventor: Beth P. Goldstein
  • Purified thrombopoietin and method of making it
    Patent number: 5986049
    Abstract: Purified mammalian thrombopoietin proteins and methods of making them are disclosed. The proteins are characterized by a M.sub.r =70,000.+-.10,000 daltons as determined by SDS-polyacrylamide gel electrophoresis under denaturing conditions and are at least 90% pure with respect to contaminating proteins. The proteins can be prepared by a method in which thrombopoietin is adsorbed to and eluted from a polypeptide comprising a ligand-binding domain of an MPL receptor, then the eluted thrombopoietin is fractionated by anion exchange chromatography.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: November 16, 1999
    Assignee: ZymoGenetics, Inc.
    Inventors: John W. Forstrom, Catherine E. Lofton-Day, Si Lok