Patents Examined by Abdel A. Mohaed
  • Didemnin analogs and fragments and methods of making and using them
    Patent number: 7122519
    Abstract: The present invention relates to macrocyclic depsipeptides, including didemnin analogs and fragments thereof, which are useful as anti-cancer agents and for other purposes. The invention includes numerous didemnin analogs and fragments and methods of making them. Methods of using these compounds as inhibitors of protein synthesis, cell growth, and tumorigenesis and as enhancers of apoptosis are also provided.
    Type: Grant
    Filed: October 25, 2002
    Date of Patent: October 17, 2006
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Madeleine M. Joullié, Bo Liang