Abstract: A polymer compound or a salt thereof which comprises a biodegradable polymer such as polyglutamic acid acetylated at N-terminal thereof containing a glycosphingolipid such as lysoganglioside GM3, and which exerts antiviral activity against variety of viruses and is useful as an active ingredient of a medicament.
Type:
Grant
Filed:
July 6, 1998
Date of Patent:
March 19, 2002
Assignee:
The Institute of Physical and Chemical Research
Abstract: It is intended to present a sensor capable of labeling with more dyes, applying the labeled protein in immunochromatography making use of antigen-antibody reaction, and having an excellent sensitivity. In a buffer, a protein and a first covalent bonding compound that can react with this protein are reacted to prepare a protein conjugate, then a cyanine labeling dye is added in the buffer containing the protein conjugate, and the protein conjugate and cyanine labeling dye are reacted to prepare a dye labeled protein conjugate. Alternatively, in a buffer solution, a protein and a cyanine labeling dye are reacted to prepare a dye labeled protein, then a first covalent bonding compound that can react with the protein is added in the buffer containing the dye labeled protein, and the dye labeled protein and first covalent bonding protein are reacted to prepare a dye labeled protein conjugate.
Type:
Grant
Filed:
November 8, 1996
Date of Patent:
October 12, 1999
Assignee:
Matsushita Electric Industrial Co., Ltd.
Abstract: A series of peptides has been found to inhibit the activity of the ribonucleotide reductase enzyme of herpes simplex virus in vitro thereby inhibiting viral replication.
Type:
Grant
Filed:
May 22, 1987
Date of Patent:
March 21, 1989
Assignee:
Merck & Co., Inc.
Inventors:
Roger Freidinger, John Hannah, Victor M. Garsky, Robert B. Stein, Richard L. Tolman