Abstract: A method for electrochemical detection (ECD) is disclosed. The illustrated embodiments are particularly adapted to use in detection of analytes separated by capillary electrophoresis. The method is a voltammetric ECD, including a preparatory positive potential pulse, an optional stabilizing pulse at a negative potential, an analytical pulse at extreme negative potentials (e.g., −300 mV to −1,500 mV), and a positive cleaning potential pulse. The methods have been shown to detect analytes previously considered to be electrochemically inactive using more traditional electrochemical methods. Examples of such analytes include various drugs, antibiotics, and peptides.
Type:
Grant
Filed:
September 13, 1999
Date of Patent:
July 2, 2002
Assignee:
Her Majesty the Queen in right of Canada, as represented by
the Canadian Food Inspection Agency
Inventors:
Geoff Charles Gerhardt, Richard Murray Cassidy, Andrzej S. Baranski