Patents Examined by Abour Razzaque
  • P21WAF1 derivatives and diagnostic methods
    Patent number: 5807692
    Abstract: The striking compartmentalization of p21.sup.WAF1 expression found in normal tissues is completely abrogated in neoplastic tissues. Methods are provided for using p21.sup.WAF1 expression as a tool to assess neoplasia and to discover new drugs. A truncated p21.sup.WAF1 protein is more active than full-length p21.sup.WAF1 protein in inhibiting tumor cell growth.
    Type: Grant
    Filed: December 18, 1995
    Date of Patent: September 15, 1998
    Assignee: The Johns Hopkins University
    Inventors: Kenneth W. Kinzler, Wafik El-Deiry, Bert Vogelstein