Abstract: An IV device assembly may include a lumen forming a fluidic channel within the IV device assembly. The lumen may be fluidically coupled to a vascular access device (VAD) coupler via a funnel coupler, and an IV device assembly coupler at a proximal end of the lumen. The IV device assembly may also include one or more of the following: a collapsible sleeve formed coaxially around a first portion of the lumen and mechanically coupled to the funnel coupler, a probe formed along a second portion of the lumen within the collapsible sleeve and into the VAD coupler, a translation handle that translates the probe out of a distal end of the VAD coupler, and a fixed grip formed around the lumen to maintain a position of the IV device assembly relative to the translation handle.

Abstract: A connector assembly for communication of medical liquids includes an attachment part for removably engaging a delivery device, a connection part for connecting a container, and a flexible sealing member circumferentially enclosed between the attachment part and connection part around a main axis. The sealing member includes a cylindrical body extending along the axis and a sealing head at an axially distal end of the sealing member with regard to the body. The attachment part includes a first inner wall surface that extends transverse or orthogonal with respect to the axis, and opposes the connection part in the direction of axis. The body is shaped and sized for maintaining a non-contact mechanical status with regard to the first inner wall surface.

Abstract: A medicament delivery device includes a first component, a second component configured to be movable with respect to the first component, and a temperature-dependent interconnect configured to resist movement of the first component relative to the second component. The temperature-dependent interconnect includes an engagement member and a temperature-dependent material configured to engage each other. The temperature-dependent material has a temperature-dependent material characteristic such that the temperature-dependent material has (i) a first material characteristic at a first temperature of the temperature-dependent material to resist movement of the first component with respect to the second component, and (ii) a second material characteristic at a second temperature of the temperature-dependent material to allow movement of the first component with respect to the second component.

Abstract: A catheter includes a handle with torqueing and steering mechanisms. The torqueing mechanism includes a rotatable nosecone and a bearing coupled to the nosecone to be rotatable therewith. The bearing is concentrically disposed over a shaft of the catheter. The steering mechanism includes a rack coupled to the bearing to be slideable therewith and a pull wire having a proximal end attached to the bearing and a distal end attached to a distal portion of the shaft. Rotation of the nosecone causes an entire length of the shaft to rotate and axial movement of the rack tensions the pull wire to bend the distal portion of the shaft. A valve relief component is slidingly disposed over the shaft and is configured to dock onto the handle when not in use.

Abstract: Disclosed herein is an insertion device for installation of a medical device comprising a transcutaneous element. The insertion device includes a device holder for holding the medical device. The insertion device also includes an installation surface configured to contact the medical device so as to deploy the transcutaneous element of the medical device. The insertion device also includes an elastic installation element configured to apply a force to the installation surface so as to bring the installation surface into contact with the medical device. The insertion device also includes a tensioner configured to adjust the force applied by the elastic installation element to the installation surface.

Abstract: A drug coated balloon includes a balloon body and a drug loaded coating layer. The drug loaded coating layer includes a first drug loaded coating component having at least two controllable sustained release drugs with different drug release kinetics, and a second drug loaded coating component including an active drug. The second drug loaded coating component is dispersed among the controllable sustained release drugs and couples the controllable sustained release drugs on the balloon body. The first and second drug loaded coating components are both non-hydrophilic compositions. The drug coated balloon provides sufficient initial drug loading dosage to the lesion site, and has adjustable drug release rate, thereby allowing the drug coated balloon to provide bioactive drugs to the treatment site at different stages of the cascade reaction of vascular restenosis, providing the controllable long-acting therapeutic drugs, and improving the overall vascular drug release efficacy.

Abstract: The present invention relates to a movement disorder monitor, and a method of measuring the severity of a subject's movement disorder. The present invention additionally relates to a treatment delivery system for treating a subject in response to changes in the severity of a subject's symptoms. The present invention further provides for a system and method, which can accurately quantify symptoms of movement disorders, utilizing continuously obtained kinetic information to be analyzed, accurately distinguishing between symptoms of movement disorders and activities of daily living, relating quantified symptoms to a standard clinical rating scale, and correlating a subject's symptoms with certain physiological and environmental factors. The present invention still further provides for home monitoring of symptoms in subjects with these movement disorders in order to capture the complex fluctuation patterns of the disease over the course of days, weeks, months, or years.

Abstract: A portable insulin pump can integrate and display data from a continuous glucose monitor (CGM) to allow a user to more readily determine whether any interaction with the pump is necessary. Data from the CGM can automatically be transmitted to the pump and can be displayed for user analysis or automatically analyzed to present recommendations to the user based on combined data from the CGM and the pump.

Abstract: The present disclosure relates to medical delivery devices that include a barrel having an inner surface that is hydrophobic. The medical delivery device includes a barrel with a hydrophobic inner surface and a stopper that can provide air and liquid impermeability while also possessing on or more of: a low break loose force, a low average glide force, and a low glide force variation. The contact angle of the inner surface of the barrel is greater than 90°.

Abstract: Provided is a device for transdermal delivery of drugs. The device includes a separable substrate and is loaded with dual drugs based on an interpenetrating polymer network hydrogel. Also provided are methods of making and using the transdermal delivery device.

Abstract: An injection device configured for attachment to the skin of a patient includes a housing and a skin adhesive layer attached to an external surface of the housing for attaching the injection device to the skin of a patient. A release liner covering the skin adhesive layer prevents the injection device from attaching to the skin. A film with one end connected to a surface inside of the housing forms a removable sterile barrier and the other end connected to an external surface of the release liner without contacting the skin adhesive layer. The housing, skin adhesive layer and release liner each include a notch defining a passage for the film so that the second end of the film can extend from the interior to the exterior of the housing.

Abstract: A medical device includes: an elongated member having a proximal end, a distal end, and a body extending between the proximal end and the distal end; wherein the elongated member includes a tubular section having a plurality of slots extending into a wall of the tubular section, the plurality of slots having a first slot; and wherein the elongated member further includes fillers respectively located in the slots, the fillers having a first filler, wherein the first filler has a spongy material located in the first slot.

Abstract: An extension set may include a tube having an outer surface. An instrument, such as a tubing or a probe, may be disposed within the tube and may include a proximal end and a distal end. A translation handle may be coupled to the outer surface of the tube and may move along the outer surface between a proximal position and a distal position to translate the distal end of the instrument between a retracted position and an advanced position. In the advanced position, the distal end of the instrument may extend beyond the distal end of the tube and into a catheter assembly and/or vasculature of a patient.

Abstract: A steering device and navigation system for interventional procedures. Included are devices, systems, and methods that incorporate a steering device which consists of an expandable structure that can be controlled to spread out within the vessel lumen, or cardiac chamber, and may apply circumferential force to the tissue. This structure, once spread out, can anchor relative to the anatomy and provides support for an internal catheter through a set of strings connected to the internal catheter. The internal catheter is configured to allow an interventional device, such as a guidewire or catheter, to pass through it. Using the strings that are connected to actuation mechanisms within the device's handle, the internal catheter can be manipulated to allow controlling the position of a device that runs within it or is connected to it and can be used for the purpose of navigation of devices and obtaining measurements from known positions.

Abstract: A liquid medicine administration device is configured to reduce the load on the power supply at the start of use and includes: a drive mechanism that advances a plunger that pushes a liquid medicine from a liquid medicine container filled with the liquid medicine toward a distal end opening of the liquid medicine container; and a control unit that controls operation of the drive mechanism, in which the drive mechanism includes a motor that applies, to the plunger, a drive force for advancing the plunger, and an encoder that detects a rotation of the motor, and when driving the drive mechanism, the control unit starts the encoder after starting the motor.

Abstract: A flow control device includes a housing having a primary inlet, a secondary inlet, and an outlet disposed downstream of the primary and secondary inlets. The flow control device further includes a chamber defined by an inner circumferential surface of the housing. The chamber fluidly connects the primary and secondary inlets with the outlet. A valve member is mounted in the chamber to pivot toward and block the primary inlet by fluid pressure in the secondary inlet when fluid pressure into the secondary inlet is higher than fluid pressure into the primary inlet.

Abstract: A supplementary device is configured to be releasably attached to an auto injector type device. The supplementary device is suitable for use with disposable one-shot auto injectors and re-usable one-shot auto injectors. The supplementary device has at least one inductive proximity sensor which outputs signals indicative of the position moveable components within the auto injector. The supplementary device is configured to determine based on the outputted signals the moment at which the auto injector changes from a pre-ejection state to a post-ejection state. In response to determining that the auto injector has changed from the pre-ejection state to the post ejection state, the supplementary device displays a visual indication that a user should hold the auto injector in its current position for a predetermined period of time.

Abstract: A catheter system may include a needle assembly coupled to a catheter adapter. The needle assembly may include a housing, an introducer needle, a distal opening, a first magnet, and a second magnet. In response to proximal withdrawal of the introducer needle, the first magnet may move towards the second magnet, which may block the distal opening and/or prevent blood from leaking out the distal opening.

Abstract: A medical device handle for articulation of a catheter includes a housing having a cylindrical shape, a control element at least partly encompassed by the housing, the control element having a pair of cross-cut threads cross-cut in opposing directions around a longitudinal axis of the medical device handle, and a pair of pull wire mounting elements each having a mounting thread engaging with one of the cross-cut threads. The control element is mechanically coupled to each of the pull wire mounting elements via the cross-cut threads and the mounting threads without any additional gear in between. A rotation of the control element around the longitudinal axis moves the pull wire mounting elements in opposite linear directions along the longitudinal axis.

Abstract: A catheter assembly includes: a catheter including a distal end portion, and a body portion that is continuous with a proximal end of the distal end portion and extends along an axial direction; a hollow inner needle that has a needle tip and is removably inserted into the catheter; and a guide wire that is inserted into the inner needle so as to be movable back and forth and that is deliverable from the needle tip. The distal end portion of the catheter includes a constituent portion that is harder than, has a higher lubricity than, or has a higher elasticity than the body portion at at least a part of a surface of the distal end portion.