Abstract: In embodiments, a Wearable Cardioverter Defibrillator (WCD) system includes a support structure for the patient to wear, and components that the support structure maintains on the patient's body. The components include a defibrillator, associated electrodes, and so on. The defibrillator can operate in a WCD mode while the patient wears the support structure. The defibrillator can further operate in a different, AED mode, during which time the patient need not wear a portion of the support structure, or even the entire support structure. Sometimes the AED mode is a type of a fully automatic AED mode. Other times the AED mode is a type of a semi-automated AED mode, where an attendant is present to administer the shock; at such times, the patient may not even need to have electrodes attached. This way the patient is more comfortable for a longer time.

Abstract: An external defibrillator apparatus (10, 74) operates to deliver electrical shocks to the heart muscles of a patient using a self-contained piezoelectric power source. The apparatus has a body (12) which includes a handle portion (26) in fixed operative connection with disposed paddle portions (14, 16). Each paddle portion includes a respective electrode (22, 24). Manual movement of a trigger (28, 78) is operative to cause circuitry (32, 82) which includes a piezoelectric crystal (34) to develop sufficient electrical potential between the electrodes to deliver the electrical shocks to the heart muscles through external contact with the patient's chest.

Abstract: Systems and methods are described for a combined Femto and Phaco surgical system built into a single housing. The system advantageously permits each of the Femto device and Phaco surgical tray to be rotated out of the way or into the position without requiring movement of a patient. Thus, a user can switch between Femto and Phaco surgical procedures without movement of the patient.

Abstract: Techniques for facilitating communication between an implantable medical device and an external device are provided. In one example, a method comprises broadcasting, via communication circuitry of an implantable device, a first set of advertisements at a first advertising rate according to a communication protocol. The method further comprises determining that detection circuitry of the implantable device detected voltage induced by an electromagnetic field at an interface between tissue of a patient and electrodes of the implantable device and in response to the detection of voltage induced by the electromagnetic field, broadcasting, via the communication circuitry, a second set of advertisements at a second advertising rate according to the communication protocol. The second advertising rate is greater than the first advertising rate.

Abstract: An electrical stimulation treatment device includes a pair of application electrodes which are disposed at a site of the skin of a person to be treated where an electrical stimulation is to be given and which supply the electrical stimulation to the skin and a control unit which is connected electrically to the application electrodes to control a magnitude of a stimulation voltage which is supplied to the application electrodes, in which the control unit includes a calculation means for calculating a magnitude of the stimulation voltage which is to be output, depending on a first maximum stimulation voltage set for each person to be treated and an elapsed time or a stimulation frequency from the start of a stimulation session of a predetermined time, and an output means for outputting the stimulation voltage while increasing the voltage in a stepwise manner based on the calculation results of the calculation means.

Abstract: An ophthalmic surgical laser system includes a laser beam delivery system having multiple moving components for scanning a laser focal spot in a target eye tissue, where the motors that actuate some of the moving components are equipped with respective digital encoders that measure actual motor positions. A controller controls the laser beam delivery system to perform a treatment scan, while recording the actual motor positions from the encoders. Using the actual motor positions and a calibration relationship between actual motor positions and delivered laser focal spot positions in a target tissue, a laser cutting pattern is digitally reconstructed, which represents the incisions actually achieved by the treatment scan. The reconstructed laser cutting pattern may be visually inspected and further analyzed, e.g. to compare it to the intended laser cutting pattern used to execute the treatment scan, to calculate the achieved refractive correction, or to simulate tissue resetting.

Abstract: Methods and devices for tissue stimulation with electromagnetic fields by frequency scan are described. The frequency scan refers to the variation of the electromagnetic field applied to a tissue via increments in frequency deltas, which adapts to tissue impedance response feedback. In addition, some methods allow determining stimulation frequency bands in order to focus stimuli in bands until the tissue impedance response returns to a tolerance level or exceeds a maximum stimulation time.

Abstract: A method of manufacturing a cannula (4) for an intravascular blood pump comprises the steps of forming a first axial section (13) and a second axial section (15) of an elongate tubular body of the cannula (4) by dispensing a first liquid material and a second liquid material, respectively, onto a mandrel (7) by means of at least one dispenser (8). The mandrel (7) is rotated and the dispenser (8) moves relative to the mandrel (7) in an axial direction during dispensing of the liquid materials. The first and second axial sections (13, 15) are formed so as to have different bending stiffnesses. The first and second liquid materials are dispensed onto the mandrel (7) such that the first and second liquid materials blend into each other to form a smooth transition area (14).

Abstract: A topical nerve activation patch includes electronic circuitry embedded in the patch and electronic circuitry configured to generate an output voltage applied to electrodes. The patch further includes a controller configured to generate a treatment comprising a plurality of activation pulses that form the output voltage, the controller comprising a first real time clock and an oscillator, the treatment comprising electrical stimuli applied to the user via the electrodes. The patch further includes a charge measurement circuit configured to measure an amount of charge applied to the user from the electrical stimuli and a communication link configured to communicate with a remote activation device, the remote activation device comprising a second real time clock. The controller is configured to generate the activation pulses by measuring time intervals using the oscillator and using the second real time clock and the measured time intervals to determine activation times for the activation pulses.

Abstract: In general, according to one embodiment, one aspect of the apparatus comprising a sensor configured to acquire biological signals of a user, the biological signals including first signals and second signals, reliability of the first signals being relatively higher than reliability of the second signals, and a controller configured to activate an alarm, if a ratio of a time period of first signals to a time period of the biological signals is less than a first threshold.

Abstract: A system (20) includes a plurality of electrodes (28), one or more radiofrequency (RF) generators (30), and a controller (36). The controller is configured to treat skin of a user (22), using one or more decision rules, responsively to multiple ascertained values of at least one parameter, by iteratively ascertaining at least one respective value of the ascertained values, by applying at least one of the decision rules to the ascertained value, identifying a treatment setting from among multiple treatment settings, and causing the RF generators to cause one or more RF currents to pass, through the skin, between at least some of the electrodes in accordance with the identified treatment setting. The controller is further configured to modify at least one of the decision rules in response to the ascertained values. Other embodiments are also described.

Abstract: In some examples, an apparatus configured to be worn by a patient for cardiac defibrillation comprises sensing electrodes configured to sense a cardiac signal of the patient, defibrillation electrodes, therapy delivery circuitry configured to deliver defibrillation therapy to the patient via the defibrillation electrodes, communication circuitry configured to receive data of at least one physiological signal of the patient from at least one sensing device separate from the apparatus, a memory configured to store the data, the cardiac signal, and a machine learning algorithm, and processing circuitry configured to apply the machine learning algorithm to the data and the cardiac signal to probabilistically-determine at least one state of the patient and determine whether to control delivery of the defibrillation therapy based on the at least one probabilistically-determined patient state.

Abstract: A device for influencing a patient's gait, comprising at least one foot lifter stimulation electrode for activating a foot lifter muscle, at least one sensor unit, at least one hip flexor stimulation electrode for activating a hip flexor muscle, and at least one control unit which is coupled to the sensor unit and the stimulation electrodes, processes sensor values from the sensor unit and, depending on the sensor values, activates at least one of the stimulation electrodes.

Abstract: An example method includes delivering, by an implantable medical device and during a first period of time, high density electrical neurostimulation therapy to a patient using a first set of electrodes of a plurality of electrodes; and delivering, by the implantable medical device and during a second period of time, high density electrical neurostimulation therapy to the patient using a second set of electrodes of the plurality of electrodes.

Abstract: A method and apparatus for treatment of cancer is provided. The method can include systemic administration of selective A3 adenosine receptor (A3AR) agonists like CI-IB-MECA (CF 101), LI-529, cordycepin or similar drugs in combination with application of pulsed Electric Field Stimulation (EFS) to the treatment area. A3AR agonists may be delivered in blend with allosteric enhancers of A3AR agonists potency like LUF6000 or other similar drugs. EFS is provided in three or more directions, which significantly increases expression of A3ARs on the cellular membranes and allows achieving a downstream apoptotic signal several-fold stronger than the signal created by an agonist alone. The apparatus may be dedicated to one patient usage over long period of time—hours and days continuously or intermittently.

Abstract: Systems and methods for predicting and treating relapses for neurological conditions in accordance with embodiments of the invention are illustrated. One embodiment includes a method for predicting and treating a clinical neurological condition relapse. The method includes steps for selecting a threshold heart rate variability value for a patient suffering from a clinical neurological condition, monitoring, using a cardiac monitor, the heart rate variability of the patient over time, providing an indicator that a relapse is imminent when the heart rate variability of the patient falls below the threshold heart rate variability value, and treating the patient using a transcranial magnetic stimulation device by applying an accelerated theta burst stimulation protocol where the transcranial magnetic stimulation target is the left prefrontal dorsolateral cortex.

Abstract: Disclosed are a wound treatment patch using static electricity, and a method for fabricating the wound treatment patch using static electricity. The patch includes a substrate made of a sticky polymer; a first electrode disposed in a first partial region of one face of the substrate and exposed to an outside; and a second electrode disposed in a second partial region other than the first partial region, and spaced apart from the first electrode, and encapsulated within the substrate, wherein each of the first electrode and the second electrode is made of hydrogel having electrical conductivity or a soft polymer having electrical conductivity.

Abstract: Systems and methods for monitoring and treating patients with heart failure (HF) are discussed. The system may sense cardiac signals, and receives information about patient physiological or functional conditions. A stimulation parameter table that includes recommended values of atrioventricular delay (AVD) or other timing parameters maybe created at a multitude of patient physiological or functional conditions. The system may periodically reassess patient physiological or functional conditions. A therapy programmer circuit may dynamically switch between left ventricular-only pacing and biventricular pacing, or switch between single site pacing and multisite pacing based on the patient condition. The therapy programmer circuit may adjust AVD and other timing parameters using the cardiac signal input and the stored stimulation parameter table. A HF therapy may be delivered according to the determined stimulation site, stimulation mode, and the stimulation timing.

Abstract: For non-invasive EP mapping, a sparse number of electrodes (e.g., 10 in a typical 12-lead ECG exam setting) are used to generate an EP map without requiring preoperative 3D image data (e.g. MR or CT). An imager (e.g., a depth camera) captures the surface of the patient and may be used to localize electrodes in any positioning on the patient. Two-dimensional (2D) x-rays, which are commonly available, and the surface of the patient are used to segment the heart of the patient. The EP map is then generated from the surface, heart segmentation, and measurements from the electrodes.

Abstract: An intracardiac pacemaker device, comprising a housing that is configured to be implanted entirely within a ventricle (V) of a heart (H), an electronic module for generating pacing pulses, a battery for supplying energy to the electronic module, an elongated lead extension protruding from the housing, at least a first electrode arranged on the elongated lead extension, and a pacing electrode and a return electrode for applying the pacing pulses to cardiac tissue, wherein the pacing electrode is arranged on the housing. The electronic module is electrically coupled to the pacing electrode via the housing, and wherein the electronic module is configured to carry out measurements of electrical activity via the at least one first electrode of the elongated lead extension.