Patents Examined by Alan L. Rotam
  • Patent number: 5843966
    Abstract: The present invention relates to piperidine derivatives of formula (I) ##STR1## wherein R.sup.1 is a C.sub.1-4 alkoxy group; R.sup.2 is ##STR2## R.sup.3 is a hydrogen or halogen atom; R.sup.4 and R.sup.5 may each independently represent a hydrogen or halogen atom, or a C.sub.1-4 alkyl, C.sub.1-4 alkoxy or trifluoromethyl group;R.sup.6 is a hydrogen atom, a C.sub.1-4 alkyl, (CH.sub.2).sub.m cyclopropyl, --S(O).sub.n C.sub.1-4 alkyl, phenyl, NR.sup.7 R.sub.8, CH.sub.2 C(O)CF.sub.3 or trifluoromethyl group;R.sup.7 and R.sup.8 may each independently represent a hydrogen atom, or a C.sub.1-4 alkyl or acyl group;x represents zero or 1;n represents zero, 1 or 2;m represents zero or 1;and pharmaceutically acceptable salts and solvates thereof; to processes for their preparation; and their use in the treatment of conditions mediated by tachykinins.
    Type: Grant
    Filed: July 23, 1997
    Date of Patent: December 1, 1998
    Assignee: Glaxo Group Limited
    Inventors: Duncan Robert Armour, Brian Evans, David Middlemiss, Tania Hubbard, Michael Menteith Hann, Xiao-Qing Lewell, Stephen Paul Watson, Alan Naylor, Neil Anthony Pegg, Maria Victoria Vinader, Gerard Martin Paul Giblin