Abstract: The present invention concerns compounds of formula (I) which is the novel 2-(1-pyrrolidinyl)ethylester of (.+-.)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxyl- or ketorolac-acid, the pharmaceutically acceptable addition salts thereof, preferably oxalate. It is known that the commercially available ketorolac (trometamole salt) exhibits undesired side effects (gastro-intestinal irritation and ulceration). Surprisingly, when applying the compounds according to the invention there are considerably less undesired effects which render them potentially of great advantage as analgetic/antiphlogistic agent.
Type:
Grant
Filed:
January 7, 1994
Date of Patent:
April 16, 1996
Assignee:
Roemmers S.A.I.C.F.
Inventors:
Carlos E. A. Monti, Gustavo Enrique Aldoma