Patents Examined by Albert Mavarro
  • typhi Ty21a expressing F1-V fusion protein and uses thereof
    Patent number: 9409956
    Abstract: Described herein is the generation of a plasmid construct for expression of a Yersinia pestis F1-V fusion protein. In the disclosed plasmid, the F1-V fusion protein coding sequence is operably linked to the E. coli htrA promoter, and is fused in-frame to the E. coli HlyA secretion signal sequence. Also described is Salmonella enterica serovar Typhi strain Ty21a containing the F1-V fusion protein expression plasmid, such as for use as an oral vaccine against plague.
    Type: Grant
    Filed: May 22, 2013
    Date of Patent: August 9, 2016
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Dennis J. Kopecko, Manuel Osorio, Monica R. Foote