Patents Examined by Alex Ramirez
  • Patent number: 12761215
    Abstract: A cell analysis device includes a determination target identifier extraction portion configured to extract a determination target identifier that is information indicating an identification substance associated with a determination target cell that is a cell of a determination target from a table indicating a corresponding relationship between the cell and the identification substance for each compartment with respect to compartments flowing along a flow path including the cell and the identification substance that is a substance associated with the cell, an identifier acquisition portion configured to acquire the identifier that is the information for identifying the identification substance included in the compartments flowing along the flow path, a determination portion configured to determine a compartment including the determination target cell among the compartments flowing along the flow path on the basis of the identifier acquired by the identifier acquisition portion and the determination target iden
    Type: Grant
    Filed: September 30, 2022
    Date of Patent: October 13, 2026
    Assignee: THE UNIVERSITY OF TOKYO
    Inventors: Sadao Ota, Yuichiro Iwamoto
  • Patent number: 12761195
    Abstract: An ultrasound indicating (USI) device and method for monitoring ultrasonication is provided. The USI device comprises a container comprising a USI formulation. The USI formulation comprises an organic liquid, a pH dye and an activator.
    Type: Grant
    Filed: October 25, 2023
    Date of Patent: October 13, 2026
    Assignee: JP Laboratories, Inc.
    Inventors: Gordhanbhai N. Patel, Julia Koleda Nordenbring
  • Patent number: 12760358
    Abstract: Embodiments disclosed herein relate to methods and systems for performing an automated assay, and particularly to performing an assay on a plurality of samples on an automated instrument.
    Type: Grant
    Filed: October 29, 2020
    Date of Patent: October 13, 2026
    Assignee: Augusta SpinCo Corporation
    Inventors: Adam Steel, Thomas Wojeck, Michael Young, Mark Larsen
  • Patent number: 12746541
    Abstract: A multi-channel head of a liquid handling apparatus for aspirating and dispensing a metered amount of liquid is configured to attach an array of disposable tips in a pick-up action, in which the multi-channel head is lowered relative to the disposable tips so as to insert each connector into an internal passageway of a corresponding disposable tip by an amount sufficient to bring an upper collar of the disposable tips into contact with an underside of the alignment plate which in turn deforms the elastomeric seal against the tip internal passageway so as to form a sealing contact therewith. An alignment action is thereafter performed in which the alignment plate is moved relative to connectors by an amount sufficient to close any gap between the underside of the alignment plate and the upper surface of the tip collars that arises due to e.g., relaxation of the deformed seals.
    Type: Grant
    Filed: December 21, 2022
    Date of Patent: September 29, 2026
    Assignee: TECAN TRADING AG
    Inventors: Lukas Fritschi, Andrea Marending
  • Patent number: 12748051
    Abstract: A cost-effective and limited interaction explosive detector for dangerous, illegal, and/or illicit substances such as explosives, flammable or volatile fluids, and/or other appropriate substances is described. The explosive detector may be integrated into various containers or packages, such as cardboard boxes, paper envelopes, metal shipping containers, and/or other containers or packaging. The integrated explosive detector may provide a visual indication when a subject substance is encountered. The integrated explosive detector may include a port or vent that allows for ambient flow of fluids, such as air, between an interior of the container and the outside environment.
    Type: Grant
    Filed: August 22, 2022
    Date of Patent: September 29, 2026
    Assignee: Siruius Solutions
    Inventor: Greg Shaffer
  • Patent number: 12734526
    Abstract: The present invention relates to a beta-component of a transfer system for a sterile isolation region, a sterile isolation region, an aseptic filling system, and a method of operating such a filling system.
    Type: Grant
    Filed: September 16, 2021
    Date of Patent: September 15, 2026
    Assignee: SYNTEGON TECHNOLOGY GMBH
    Inventors: Ulrich Krauß, Patrick Holl, Markus Ilgenfritz, Andreas Bernhard
  • Patent number: 12736489
    Abstract: An NMR spectrum is acquired from a nucleus of interest in a solvent included in a sample solution. A spectrum analyzer analyzes a number of splits, a splitting interval, a number of signals, and a signal interval based on the NMR spectrum. Based on these characteristic quantities, an identifier identifies the solvent. In another configuration, a plurality of NMR spectra acquired from a plurality of nuclei of interest included in the solvent may be analyzed.
    Type: Grant
    Filed: August 10, 2022
    Date of Patent: September 15, 2026
    Assignee: JEOL Ltd.
    Inventors: Hiroaki Sasakawa, Katsuo Asakura, Kenya Izumi
  • Patent number: 12736549
    Abstract: An insert for a holding device for reliably and accurately assessing a small volume of blood in a fluid, such as in a volume of surgical fluid collected during a surgical procedure, is provided. The insert may include a circular shelf having an outside perimeter configured to fit up against an inside perimeter of a holding device. The insert may include a center opening. The insert may include a conically-shaped collection cone disposed in the center opening. The collection cone may include a length, an interior surface comprising a red blood cell flocculant coating, a gradually decreasing perimeter terminating in a bottom apex, and a series of graduated volumetric markings along the length of the collection cone.
    Type: Grant
    Filed: December 3, 2020
    Date of Patent: September 15, 2026
    Assignee: CYPHER MEDICAL, LLC
    Inventor: Christopher A. Carew
  • Patent number: 12724024
    Abstract: A sample analysis system, method and a cell image analysis device. The sample analysis system includes a blood cell analyzer, a smear preparation apparatus, a cell image analysis apparatus, and a controller. The controller obtains a test result of at least one sample from the blood cell analyzer. When one sample needs to be analyzed by the cell image analysis device, the controller can further control an imaging condition used by the cell image analysis device according to a value of at least one type of cells in the test result of the sample, such that the cell image analysis device can automatically selects an imaging condition matching the test result for imaging according to different test results of the sample. Therefore, a matching imaging condition is used to specifically capture and analyze cell images of a smear of the sample, thereby improving processing efficiency and accuracy.
    Type: Grant
    Filed: June 29, 2022
    Date of Patent: September 1, 2026
    Assignee: Shenzhen Mindray Bio-Medical Electronics Co., Ltd.
    Inventors: Huan Qi, Chaoyang Li, Yi Ye, Bo Ye, Shan Yu, Jin Li, Xuerong Li
  • Patent number: 12687546
    Abstract: An object of the present invention is to provide a reagent kit, a measurement kit, and a measurement method for measuring serum amyloid A, which enable simple and rapid measurement of serum amyloid A by promoting dissociation of the serum amyloid A from HDL and carrying out an antigen-antibody reaction. According to the present invention, provided is a reagent kit for measuring serum amyloid A, including first particles having a label and modified with a first binding substance having a property of specifically binding to serum amyloid A, at least one nonionic surfactant having an HLB value of 17 to 20, which is defined by (inorganicity value/organicity value)×10, and a molecular weight of 1000 or less, and a buffer capable of adjusting a pH of a reaction solution to be in a range of 5.5 to 7.0 or a range of 8.5 to 9.0.
    Type: Grant
    Filed: July 30, 2021
    Date of Patent: July 21, 2026
    Assignee: FUJIFILM Corporation
    Inventors: Kazuhiro Nakamura, Ryo Ouchi, Takeru Shigemura
  • Patent number: 12687480
    Abstract: A flow cell of the flow cytometer of the present invention includes: a sample flow path through which a sample fluid containing a sample flows; and a sample fluid supply portion which communicates with an upstream end of the sample flow path in the sample fluid flow direction and supplies the sample fluid to the sample flow path, wherein the sample fluid supply portion includes a plurality of sample opening portions which supply a sample fluid to the sample flow path, a cleaning liquid supply opening portion to which a second tube is connectable and which supplies a cleaning liquid for cleaning the sample fluid supply portion, and a cleaning liquid discharge opening portion to which a first tube is connectable and which discharges the cleaning liquid from the sample fluid supply portion.
    Type: Grant
    Filed: January 21, 2021
    Date of Patent: July 21, 2026
    Assignee: THINKCYTE K.K.
    Inventors: Yoko Kawamura, Keiji Nakagawa, Keisuke Toda
  • Patent number: 12661645
    Abstract: The present invention relates to a mini-pipette, and more particularly, to a mini-pipette which has capacity varying means that can vary the movement distance of a push button reciprocating in the outer body to generate suction force so that a variety of samples can be easily collected. The present invention provides a mini-pipette comprising: an outer body having a hollow movement space and a suction passage formed at a lower part of the outer body; a push button for generating negative or positive pressure in the suction passage while reciprocating in the movement space of the outer body; elastic means for elastically supporting the push button in the movement space; and a capacity varying means formed inside the outer body, for varying a movement distance of the push button in the movement space.
    Type: Grant
    Filed: September 13, 2021
    Date of Patent: June 23, 2026
    Assignee: BODITECH MED INC.
    Inventors: Sang Hyun Park, Byeong Chul Kim
  • Patent number: 12656362
    Abstract: An analyzer having an inner chassis surrounded by a housing includes sample and dilution probes, a mixing housing including first and second mixing chambers, a flow cytometer including a flow cell, and sample and sheath pumps configured to perform first and second pluralities of tasks, respectively. The first plurality of tasks includes: aspirating sample into the sample probe, dispensing sample from the sample probe into the first and second mixing chambers, delivering first sample-dilution fluid mixture to the flow cell, and delivering second sample-dilution fluid mixture to the flow cell. The second plurality of tasks includes: dispensing sheath to the flow cell in cooperation with the delivery of the first sample-dilution fluid mixture to the flow cell, and dispensing sheath to the flow cell in cooperation with the delivery of the second sample-dilution fluid mixture to the flow cell.
    Type: Grant
    Filed: May 7, 2024
    Date of Patent: June 16, 2026
    Assignee: IDEXX LABORATORIES INC.
    Inventors: Jonathan W. Lawrence, Mark R. Dumont, Jason J. Aguiar, John H. McGibbon, Nicholas P. Prince
  • Patent number: 12648238
    Abstract: A photodiode (112, 200, 400, 500) includes a semiconductor substrate (210) having a first surface (211) and a second surface (212, 412, 512), and a light sensing junction (220) located adjacent to the first surface (211). The second surface (212, 412, 512) is located opposite the first surface (211), and the second surface (212, 412, 512) includes a concave surface covering a recessed region (415, 515) in the semiconductor substrate (210).
    Type: Grant
    Filed: November 29, 2019
    Date of Patent: June 2, 2026
    Assignee: MGI Tech Co., Ltd.
    Inventors: Shifeng Li, Cheng Frank Zhong
  • Patent number: 12618814
    Abstract: A system for monitoring the alkalinity of a treatment liquid in a treatment tank includes a reaction tank; an indicator burette which drops an indicator into the reaction tank; a reagent burette which drops an acidic reagent into the reaction tank; a probe-type absorptiometer to be inserted into the reaction tank; a measuring device which analyzes the transmittance of a solution detected by the absorptiometer to calculate the alkalinity; a first system that collects the treatment liquid from the treatment tank for storing and supplies the treatment liquid to the reaction tank; a control device which controls the operation of the first system so as to supply the treatment liquid to the reaction tank, outputs a completion signal to the measuring device, and controls a discharge system so as to discharge the treatment liquid in the reaction tank, when the calculation of alkalinity by the measuring device is completed.
    Type: Grant
    Filed: August 4, 2020
    Date of Patent: May 5, 2026
    Assignee: MITSUBISHI HEAVY INDUSTRIES, LTD.
    Inventors: Masaru Chiyomaru, Hiroaki Mikawa, Yuichi Okuzaki
  • Patent number: 12616970
    Abstract: Example implementations include a method of manufacturing a biochemical sensor by forming a fluid conduit in a microfluidic layer, forming an electrode on an electrode layer, forming a biochemical sensor on the electrode layer, bonding the electrode layer to a first surface of the microfluidic layer, and bonding a barrier layer to a second surface of the microfluidic layer. Example implementations also include a method of electrically detecting a biochemical by contacting an electrode array to a biological surface, obtaining a biofluid at the electrode array from the biological surface, obtaining a response current associated with the biofluid at the electrode array, and generating a quantitative biochemical response based at least partially on the response current. Example implementations further include applying a current to the biological surface. Example implementations further include filtering electrical interference at the electrode array.
    Type: Grant
    Filed: September 25, 2020
    Date of Patent: May 5, 2026
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Sam Emaminejad, Yichao Zhao, Bo Wang
  • Patent number: 12605711
    Abstract: A pouch for a diagnosis item includes (i) a pocket portion with a storage space configured to hold a buffer that has an elongate shape and is configured to hold a sample diluent, and (ii) a buffer supporter formation portion that is connected to one side of the pocket portion. The buffer supporter formation portion includes a buffer support hole that is sized to receive the buffer and support the buffer such that the buffer is oriented in an upright state to avoid spilling of the sample diluent. The buffer supporter formation portion includes a shelf supported by leg portions. The shelf includes the buffer support hole. The buffer supporter formation portion is configured to allow bending of the buffer supporter formation portion into a U shape, and to hold the U shape after being detached from the pocket portion.
    Type: Grant
    Filed: December 6, 2022
    Date of Patent: April 21, 2026
    Inventor: Jae Ku Park
  • Patent number: 12594550
    Abstract: A biological sample holding container includes: a container main body having a bottom surface portion having a placement region for a biological sample and a side surface portion provided on the bottom surface portion so as to surround the placement region; and an annular holding member insertable and removable inside the side surface portion. The holding member holds a film covering the biological sample on the placement region with the bottom surface portion by being inserted inside the side surface portion together with the film.
    Type: Grant
    Filed: July 16, 2020
    Date of Patent: April 7, 2026
    Assignee: HAMAMATSU PHOTONICS K.K.
    Inventors: Kazumasa Hirawake, Takahiro Murakoshi, Takahiro Shikayama, Takayuki Sato
  • Patent number: 12584832
    Abstract: The invention discloses a low-energy consumption solvent dilution device for pre-treating samples comprising an accommodating unit, the accommodating unit including a case and an accommodating portion arranged inside the case; an input unit, which including an inlet, a second outlet and a third outlet extending into the case; a cleaning unit, which including a receiving assembly arranged below the second outlet and the third outlet, and a conveying assembly communicated with a receiving assembly. The input unit including a first tube connecting with the inlet, and a second tube and a third tube extending out of the second outlet and the third outlet, respectively. The present invention completes dispensing and diluting the sample fixative in the box, the dispersion of the fixative is reduced. Avoid unnecessary contact for operators. It improves the safety and accuracy of the experiment, and significantly reduces energy consumption and labor costs.
    Type: Grant
    Filed: November 10, 2020
    Date of Patent: March 24, 2026
    Assignee: Freshwater Fisheries Research Institute of Jiangsu Province
    Inventors: Yanshan Liu, Tongqing Zhang, Shengkai Tang, Daming Li, Xiaowei Liu, Xiankun Gu, Dongdong Shen
  • Patent number: 12577343
    Abstract: A peptide-imprinted conductive polymer and use thereof is provided, especially a peptide-imprinted conductive polymer including conductive polymer monomer(s), two-dimensional (2D) material(s), and a small peptide fragment of ?-synuclein as template. The peptide-imprinted conductive polymer has high sensibility, detects ?-synuclein at low concentrations, thus allowing early diagnosis and treatment of Parkinson's disease.
    Type: Grant
    Filed: July 13, 2021
    Date of Patent: March 17, 2026
    Assignee: National University of Kaohsiung
    Inventors: Hung-Yin Lin, Mei-Hwa Lee, Chien-Hsin Yang, Zi-Lin Su