Patents Examined by Alexander Noguerola
  • Patent number: 9910008
    Abstract: Device and methods for use in a biosensor comprising a multisite array of test sites, the device and methods being useful for modulating the binding interactions between a (biomolecular) probe or detection agent and an analyte of interest by modulating the pH or ionic gradient near the electrodes in such biosensor. An electrochemically active agent that is suitable for use in biological buffers for changing the pH of the biological buffers. Method for changing the pH of biological buffers using the electrochemically active agents. The methods of modulating the binding interactions provided in a biosensor, analytic methods for more accurately controlling and measuring the pH or ionic gradient near the electrodes in such biosensor, and analytic methods for more accurately measuring an analyte of interest in a biological sample.
    Type: Grant
    Filed: July 6, 2015
    Date of Patent: March 6, 2018
    Assignee: ROBERT BOSCH GMBH
    Inventors: Christopher Johnson, Sam Kavusi, Rajan Gangadharan, Piyush Verma, Aldrich Lau, Nadezda Fomina, Habib Ahmad
  • Patent number: 9897571
    Abstract: The invention concerns a size marker for electrophoresis, characterized in that it contains several pairs of molecules the sizes of which are selected to allow the generation of a succession of double-peaks in one same electropherogram, said double-peaks being spaced apart two by two by a distance greater than the distance separating the two peaks of a double-peak. The invention also concerns a method for controlling the resolution of an electropherogram produced with a said marker.
    Type: Grant
    Filed: June 4, 2015
    Date of Patent: February 20, 2018
    Assignee: MORPHO
    Inventors: Benoit Tonson, Marcelin Ragot, Marina Pouet
  • Patent number: 9873129
    Abstract: The present invention provides for microelectrode array devices and method of making and using same for the purpose of isolating and analyzing micro- and nanoparticles contained within a fluid solution. In various aspects, the present invention is designed to take advantage of electrokinetics and the separation of certain forces in order to influence and control small particles in a fluid solution, thereby allowing further analysis to be conducted on such particles.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: January 23, 2018
    Inventor: David Jean Charlot
  • Patent number: 9873902
    Abstract: The invention relates to a method of and apparatus for determining concentration of an analyte, such as glucose, in a fluid sample, such as body fluid or control solution, using a mediated redox reaction. In particular, the method relates to mitigation of the effects of haematocrit on the response of sensor device used in such a method or apparatus.
    Type: Grant
    Filed: June 17, 2014
    Date of Patent: January 23, 2018
    Assignee: SURESENSORS LIMITED
    Inventor: Geoffrey Frank Hall
  • Patent number: 9874538
    Abstract: Device and methods for use in a biosensor comprising a multisite array of test sites, the device and methods being useful for modulating the binding interactions between a (biomolecular) probe or detection agent and an analyte of interest by modulating the pH or ionic gradient near the electrodes in such biosensor. An electrochemically active agent that is suitable for use in biological buffers for changing the pH of the biological buffers. Method for changing the pH of biological buffers using the electrochemically active agents. The methods of modulating the binding interactions provided in a biosensor, analytic methods for more accurately controlling and measuring the pH or ionic gradient near the electrodes in such biosensor, and analytic methods for more accurately measuring an analyte of interest in a biological sample.
    Type: Grant
    Filed: July 6, 2015
    Date of Patent: January 23, 2018
    Assignee: ROBERT BOSCH GMBH
    Inventors: Christopher Johnson, Sam Kavusi, Rajan Gangadharan, Piyush Verma, Nadezda Fomina, Habib Ahmad, Aldrich Lau, I
  • Patent number: 9864345
    Abstract: A process for creating a predictive data set predicting the amount of target constituents are in an electrolyte solution at varying temperatures is provided.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: January 9, 2018
    Assignee: TECHNIC, INC.
    Inventors: Kazimierz Wikiel, Aleksander Jaworski, Wojciech Wikiel
  • Patent number: 9857330
    Abstract: A method is provided for diagnosing a reference channel of a broadband lambda probe that is used to determine an oxygen concentration in an exhaust gas, at least one sensor element having a pump cell and a Nernst cell being used; in one measurement mode, a regulated pumping current flowing through the pump cell to determine the oxygen concentration in the exhaust gas, and thus an exchange of oxygen ions between a measuring cell and the exhaust gas being achieved, and a lambda value in the measuring cell being regulated to a value of 1; the lambda value in the measuring cell being monitored through the Nernst cell, and the value of the pumping current required for that purpose being dependent on the oxygen concentration and thus on the lambda value of the exhaust gas to be determined.
    Type: Grant
    Filed: September 30, 2013
    Date of Patent: January 2, 2018
    Assignee: Robert Bosch GmbH
    Inventor: Bernhard Ledermann
  • Patent number: 9856448
    Abstract: Nanoscale probes for forming stable, non-destructive seals with cell membranes. The probes, systems including these probes, and methods of fabricating and using the probes described herein may be used to sense from, stimulate, modify, or otherwise effect individual cells or groups of cells. In particular, described herein are nanoscale cellular probes that may be used to fuse with, and in some variations span, the lipid membrane of a cell to provide stable and long lasting contact to the cell. Thus, the probes described herein may be used as part of a system, method or device that would benefit from stable, non-destructive access to and across a cell membrane. In some variations the nanoscale probe devices or systems described herein may be used as part of a drug screening procedure.
    Type: Grant
    Filed: August 15, 2014
    Date of Patent: January 2, 2018
    Assignee: The Board of Trustees of the Leland Stanford Junior Univesity
    Inventors: Nicholas Alexander Melosh, Piyush Verma, Benjamin David Almquist
  • Patent number: 9846137
    Abstract: The subject invention provides materials and methods of fabricating and using an electrochemical biosensor for continuous detection of biological analytes. In a specific embodiment, the biosensor detects a given analyte when the analyte binds with a molecularly imprinted polymer (MIP) matrix immobilized atop a sensing substrate eliminating the need for a redox probing agent commonly found in electrochemical biosensors. Furthermore, the detection sensitivity of the biosensor is enhanced by modifying the electrode surface with a plurality of nanoscopic metallic structures. Advantageously, technologies provided herein can be used in a variety of low-power electronics for wearable applications.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: December 19, 2017
    Assignee: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTESS
    Inventors: Shekhar Bhansali, Pandiaraj Manickam
  • Patent number: 9846142
    Abstract: A mechanism is provided for presenting single strands of a double strand molecule to a membrane. The double strand molecule is driven to a first side of the membrane by an electric field. The membrane has a first and second nanopore spaced apart by a nanopore separation distance. The first strand of the double strand molecule is captured in the first nanopore when driven to the first side of the membrane. The second strand is captured in the second nanopore by having the nanopore separation distance between the first nanopore and the second nanopore corresponding to a strand separation distance between the first and second strands, and/or by having captured the first strand to limit diffusion of the second strand. The first and second strands respectively in the first and second nanopores are individually stretched, by the first and second strands recombining on the second side of the membrane.
    Type: Grant
    Filed: June 22, 2015
    Date of Patent: December 19, 2017
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventor: Ajay K. Royyuru
  • Patent number: 9846141
    Abstract: A mechanism is provided for presenting single strands of a double strand molecule to a membrane. The double strand molecule is driven to a first side of the membrane by an electric field. The membrane has a first and second nanopore spaced apart by a nanopore separation distance. The first strand of the double strand molecule is captured in the first nanopore when driven to the first side of the membrane. The second strand is captured in the second nanopore by having the nanopore separation distance between the first nanopore and the second nanopore corresponding to a strand separation distance between the first and second strands, and/or by having captured the first strand to limit diffusion of the second strand. The first and second strands respectively in the first and second nanopores are individually stretched, by the first and second strands recombining on the second side of the membrane.
    Type: Grant
    Filed: January 29, 2015
    Date of Patent: December 19, 2017
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventor: Ajay K. Royyuru
  • Patent number: 9846166
    Abstract: The present invention relates to a biosensor that uses a cell that expresses a chemosensory receptor that can detect sugar, and an Alzheimer's disease diagnostic apparatus comprising the same. The biosensor and the Alzheimer's disease diagnostic apparatus of the present invention can sensitively detect a particular sugar in a sample, more inexpensively and more quickly, by fixing a drosophila cell having an over-expressed target sensory receptor protein on the cell surface through genetic engineering, and can thereby be efficaciously used for diagnosing Alzheimer's disease.
    Type: Grant
    Filed: October 4, 2013
    Date of Patent: December 19, 2017
    Assignee: KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Jeong Ok Lim, Won Ju Cho, Jeung Soo Huh
  • Patent number: 9835613
    Abstract: A method for measuring ammonia in a blood sample may involve positioning the blood sample in proximity with an ammonia gas sensor, generating a current with the ammonia gas sensor in response to ammonia gas released from the blood sample, and measuring the current generated by the ammonia gas sensor, using a current measurement member coupled with the ammonia gas sensor. A device for measuring an ammonia level in a blood sample may include a blood sample containment member, an ammonia gas sensor coupled with the blood sample containment member, and a current measurement member coupled with the ammonia gas sensor. The method and device may be used to measure an ammonia level in a blood sample as small as one drop of blood, or approximately 0.05 mL of blood.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: December 5, 2017
    Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Thomas Richard Veltman, Chun J. Tsai, Matthew William Kanan, Gilbert Chu
  • Patent number: 9823213
    Abstract: An electrochemical test strip, measurement system and method for determining sample content in the reactive region of the electrochemical test strip are presented. The electrochemical test strip comprises an insulator substrate which includes an electrode system disposed thereon. The electrode system includes at least one pair of electrodes. A lower plate which includes a reactive region and a sampling cell is disposed on the insulator substrate. An upper plate is disposed on the lower plate, wherein the at least one pair of electrodes is designed as an electrical loop adjacent to the sampling port.
    Type: Grant
    Filed: August 21, 2015
    Date of Patent: November 21, 2017
    Assignee: Apex Biotechnology Corp.
    Inventors: Ching Yuan Chu, Chun Ming Cheng, Po Min Wang, Lee Teng Yi Wu
  • Patent number: 9816957
    Abstract: Provided is a blood component measuring device or the like that can further suppress the measurement error of a blood component. The device detects an oxidation-reduction current generated by oxidation-reduction when a first voltage is applied to a first electrode pair 21, 22 of a biosensor 1, and converts the oxidation-reduction current (glucose response value) into a glucose conversion value. The device detects a current generated when a second voltage is applied to a second electrode pair 23, 24 of the biosensor 1, and converts the detected current (blood cell amount response value) into a blood cell amount conversion value. The glucose response value is measured more than once and the blood cell amount response value is also measured more than once within a predetermined period after the introduction of the blood into the biosensor 1.
    Type: Grant
    Filed: November 19, 2013
    Date of Patent: November 14, 2017
    Assignee: Panasonic Healthcare Holdings Co., Ltd.
    Inventors: Masaki Fujiwara, Tomohiro Yamamoto
  • Patent number: 9816959
    Abstract: The subject invention provides devices, and methods of making and using the same, for the non-invasive detection of ethanol in a sample. In specific embodiments, the fuel cell based ethanol detector of the subject invention is capable of measuring the concentration of ethanol vapor in the presence of water vapor, which is known to confound signal readings in conventional detectors. Advantageously, the electrochemical sensors provided herein are highly stable and accurate, especially suitable for low-cost, continuous monitoring of ethanol content in transdermal perspiration samples.
    Type: Grant
    Filed: December 29, 2015
    Date of Patent: November 14, 2017
    Assignee: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES
    Inventors: Yogeswaran Umasankar, Shekhar Bhansali
  • Patent number: 9810656
    Abstract: The application relates to an electrode for use in the electrochemical detection of a target species, wherein the electrode has a planar surface disposed on which are probe molecules that are capable of binding selectively to the target species, wherein the electrode, prior to binding of the probe molecules with the target species, has an electron transfer resistance per area of the electrode of from 10 megaohms cm?2 to 95 megaohms cm?2.
    Type: Grant
    Filed: May 1, 2013
    Date of Patent: November 7, 2017
    Assignees: Oxford University Innovation Limited, Universidade Estadual Paulista “Julio de Mesquita Filho”
    Inventors: Jason Davis, Paulo Roberto Bueno
  • Patent number: 9810655
    Abstract: Provided are a hydrogen ion electrode composed of a composite material of polymer resin and nano iridium oxide, the composite material containing 1-10 nm sized nano iridium oxide particles and/or aggregates thereof which are dispersed to be electrically connected to each other in a moldable, thermoplastic, and hydrophobic polymer resin matrix; a pH sensor using the same; and a method for manufacturing the same. The surface of the hydrogen ion electrode shows very fast pH sensitivity when exposed to a sample solution, and the pH sensitivity is approximate to biphasic characteristics. Furthermore, regardless of high reproducibility of pH sensitivity, abrupt pH change, and repetitive use, very low hysteresis, durability due to high physical strength, and high surface regeneration due to polishing are exhibited, and thus, the lifetime of the electrode can be extended and various sizes and shapes of electrodes can be easily manufactured.
    Type: Grant
    Filed: August 14, 2014
    Date of Patent: November 7, 2017
    Assignee: EZ SENSING INC.
    Inventors: Jong Man Park, Moonhee Kim
  • Patent number: 9810663
    Abstract: The present invention generally relates to devices and methods for containing molecules. In some embodiments, the device comprises a nanopore, a pore, and a cavity capable of entropically containing (e.g., trapping) a molecule (e.g., a biomolecule), e.g., for minutes, hours, or days. In certain embodiments, the method comprises urging a molecule into a cavity of a device by application of an electric field, and/or by deposition of fluids having different ionic strengths. The molecule may comprise, in some cases, nucleic acids (e.g., DNA). The molecule, when present in the cavity and/or the nanopore, may be capable of being analyzed, determined, or chemically modified. In some instances, a second molecule (e.g., a second molecule which interacts the first molecule) may also be urged into the cavity. In some embodiments, the interaction of the second molecule with the first molecule (e.g.
    Type: Grant
    Filed: January 26, 2015
    Date of Patent: November 7, 2017
    Assignee: Brown University
    Inventors: Derek M. Stein, Xu Liu, Mirna Mihovilovic Skanata
  • Patent number: 9793560
    Abstract: A Method and device for measurement is disclosed in operation, an undivided cell sensor immersed at any desirable point of the positive electrolyte circuit is constantly supplied at a controlled fixed DC bias voltage between the positive metal electrode and the porous carbon counter-electrode by an appropriate voltage regulator of adequate power capability, or cyclically at two or more different voltages, all within a range that includes the region between 0.35V and 0.45V, measuring simultaneously the current flowing across the undivided cell sensor at the fixed voltage or voltages bias. By correlating the paired voltage and current values, using a look up table compiled at calibration, estimated values of the degree of oxidation or state of charge of the redox ion couple of the positive electrolyte solution are produced.
    Type: Grant
    Filed: May 16, 2013
    Date of Patent: October 17, 2017
    Assignee: HYDRAREDOX TECHNOLOGIES HOLDINGS LTD.
    Inventors: Placido Maria Spaziante, Michael Dichand