Abstract: Various embodiments for a method that allow for a more accurate analyte concentration with a biosensor by determining at least one physical characteristic of the sample and determining whether a counter or reference electrode is causing an error by monitoring the working electrodes and flagging an error if the signal outputs of the working electrodes do not meet certain thresholds.

Abstract: The present invention provides a test strip for measuring a signal of interest in a biological fluid when the test strip is mated to an appropriate test meter, wherein the test strip and the test meter include structures to verify the integrity of the test strip traces, to measure the parasitic resistance of the test strip traces, and to provide compensation in the voltage applied to the test strip to account for parasitic resistive losses in the test strip traces.

Abstract: The present invention relates to a plastic capillary tube for capillary electrophoresis, in which the plastic capillary tube has an inlet opening and an outlet opening and, furthermore, has at least one hole in the capillary tube wall and the diameter of the hole on the inside of the capillary tube wall dL(innen) lies in the range from 0.5 ?m to 30 ?m.

Abstract: The disclosure relates to novel methods for performing a solution based assay reaction with an electroactive active moiety (EAM) that subsequently forms a self-assembled monolayer (SAM) utilizing the advantages of faster solution reaction kinetics, SAM protected electrode and surface based electrochemistry for electronic measurement.

Abstract: An electrophoresis system is provided. The system includes a buffer chamber box having a front surface. The buffer chamber box is divided into a first chamber and a second chamber by a divider. The system also includes a gel plate. A gel chamber is formed by the gel plate and the front surface of the buffer chamber box. The first chamber has a first electrode and a first conductive path member. The second chamber has a second electrode and a second conductive path member.

Abstract: A system includes a polymeric housing and a first connector in electrically conductive connection with a first component within the housing. The first connector includes a first extending member formed from a conductive loaded polymeric material. The first extending member is formed such that an interior thereof includes conductive elements within a matrix of the polymeric material so that the interior is electrically conductive and an exterior surface thereof comprises the polymeric material and is less conductive than the conductive interior. The conductive interior of the first extending member is in electrically conductive connection with the first component. The first connector further includes a first extending conductive element in electrical connection with the conductive interior of the first extending member. The first extending conductive element extends from the first extending member to pass through the polymeric housing.

Abstract: A biosensor and a method for recognizing a liquid sample are provided, which can recognize whether a sample is introduced by recognizing an inside of a sample introduction channel through measurement of capacitance. The biosensor includes an upper plate and a lower plate facing each other, a middle plate interposed between the upper plate and the lower plate to form a sample introduction channel through a recess portion, a working electrode and an auxiliary electrode formed in the sample introduction channel, a sample recognition electrode formed on an outside of the sample introduction channel in a position that corresponds to the sample introduction channel, and a capacitance measurement portion electrically connected to any one of the working electrode and the auxiliary electrode and the sample recognition electrode.

Abstract: A method of determining concentrations of a plurality of analytes from a single blood sample placed in a single opening. A portion of the single blood sample is absorbed by a test matrix that includes a plurality of layers and a chromogenic agent. A colored response is generated by the test matrix. The colored response is proportional to the concentration of a first analyte. A portion of the single blood sample is drawn into a capillary tube and placed in contact with an electrode and a counter-electrode. An electrical property of the single blood sample is analyzed through the electrode and counter-electrode. The electrical property is proportional to the concentration of a second analyte in the single blood sample.

Abstract: Measurement systems and methods are disclosed for minimizing the effects created by a meter's output amplifier during electrochemical measurements. In the systems and methods, transition of an excitation potential applied between electrodes of a test strip is controlled so that it is at a sufficiently slow rate below a slew rate capability of the system (but still fast enough to minimally impact overall test time) to reduce variability in the test results. The methods and systems therefore use a transition having a ramp-shaped waveform, a sinusoidal-shaped waveform or an exponential-shaped waveform. Additionally, the excitation potential can be purposefully controlled by a processor, memory driven digital-to-analog converter or external circuitry at a rate sufficiently slow to make variations in the analog electronics slew rate insignificant for all sample types and test conditions.

Abstract: The present invention provides a new and improved oligonucleotide detection method based on the nanopore technology with a probe containing a complementary sequence to the target oligonucleotide and a terminal extension at the probe's 3? terminus, 5? terminus, or both termini. The improved nanopore sensor with the probe enables sensitive, selective, and direct detection, differentiation and quantification of target oligonucleotides such as miRNAs. The inventive detection method may also be employed as a non-invasive and cost-effective diagnostic method for cancer detection based on miRNA levels in the patient's blood sample.

Abstract: An electrochemical gas sensor, particularly for the detection of ammonia and/or amines, with an ionic fluid as an electrolyte, wherein the ionic fluid contains at least one protic ammonium cation with at least one dissociable hydrogen atom, whereby the at least one protic ammonium cation reacts with the ammonia and/or amines to be measured via deprotonation. The present invention also relates to the use of such a gas sensor.

Abstract: The present invention includes methods, devices and systems for isolating nanoparticulates, including nucleic acids, from biological samples. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity isolation of biological components from complex fluids such as blood or environmental samples.

Abstract: Electrophoresis gel cassette comprising a first and a second face wall member and one or more side wall members defining a gel compartment for a gel member with a first and second face, wherein at least a section of each one of the first and second face wall member is removable to expose a section of both the first and second face of the gel member essentially corresponding to the separation zone while the gel member is preserved in the cassette.

Abstract: The invention relates to a microfabricated device and methods of using the device for analyzing and sorting polynucleotide molecules by size.

Abstract: Electrophoresis gel cassette comprising a cassette housing defining a gel compartment for molding a gel member wherein the gel compartment comprises a fill port at an inlet end of the gel compartment and one or more over-fill ports at a distal end of the gel compartment with respect to a filling direction, and wherein the over-fill port(s) is arranged in fluidic communication with an overfill chamber.

Abstract: Provided is a method for accurately quantifying a chemical substance contained in a sample solution at a significantly low concentration of not more than 1×10?8M. A measurement system used for the method includes a counter electrode 13, a first reference electrode 12, a first working electrode 11a, a second working electrode 11b, a second reference electrode 14 and a gel-coated electrode 15. The gel-coated electrode 15 is electrically equivalent to the second working electrode 11b. The gel-coated electrode 15 comprises an electrode body 31 and a gel 34. The surface of the electrode body 31 is coated with the gel 34. The gel 34 contains a standard electrolyte and an ionic liquid. The gel 34 contains no water. The ionic liquid is hydrophobic and nonvolatile. The ionic liquid is composed of a cation and an anion. The standard electrolyte is composed of the cation and a halide ion.

Abstract: A multiple layer gel and method for forming a multiple layer gel are provided. The multiple layer gel includes an isolation layer and an electrolyte layer. The isolation layer provides a molecular weight screen, to prevent proteins or other molecules from contacting a reference cell covered by the isolation layer. The electrolyte layer covers the isolation layer, and provides a source of ions that place the reference cell in ionic and/or electrical contact with a fluid sample. The multiple layer gel can be used to maintain a reliable reference voltage from an associated reference cell while an electrical potential or other electrical characteristic of a sample fluid is being determined.

Abstract: A nanosensor for detecting molecule characteristics includes a membrane having an opening configured to permit a charged carbon nanotube to pass but to block a molecule attached to the carbon nanotube. The opening is filled with an electrolytic solution. An electric field generator is configured to generate an electric field relative to the opening to drive the charged carbon nanotubes through the opening. A sensor circuit is coupled to the electric field generator to sense current changes due to charged carbon nanotubes passing into the opening, and to bias the electric field generator to determine a critical voltage related to a force of separation between the carbon nanotube and the molecule.

Abstract: Provided is a hydrogen measurement sensor capable of monitoring a content of hydrogen within molten metal in real-time using an aluminum or magnesium alloy casting method, and, more particularly, a hydrogen measurement sensor having a junction structure of a solid oxygen ion conductor and a solid hydrogen ion conductor in molten metal capable of measuring a content of hydrogen within aluminum-magnesium alloy-molten metal using a new method which generates a fixed concentration of oxygen gas from a solid reference material at a high temperature by replacing a reference material of a standard gas method which is difficult to handle with a solid reference material or external air which is easy to handle or has the same effect as that of the gas reference material by using a feature in which the external air contains a predetermined pressure (0.21 atm) of oxygen.

Abstract: Electrophoresis tray arranged to support an electrophoresis cassette for miming electrophoresis experiments, the electrophoresis cassette comprising a gel member in a housing with a front and a back face, wherein the tray comprises a cassette support surface for supporting at least the separation zone of the electrophoresis cassette during electrophoresis, and wherein the cassette support surface is flanked by a pair of buffer pad holders each one arranged to hold a buffer pad in a mating position with respect to buffer connection sections at the back face of the electrophoresis cassette.