Abstract: A tool to determine a pre-puncture needle shape to provide a desired approach to a target location based on measured patient anatomy is disclosed herein. Anatomical relationship between an outlet of an access vessel and a desired puncture sight on the interatrial septum is used to determine the pre-puncture needle shape. The tool may be used to provide a recommended preferred needle shape from a collection of predetermined needle shapes (e.g. commercially available needle shapes) and/or recommend a bent shape to which a physician may modify a predetermined needle shape to fit. Additionally, or alternatively, the tool may be used to provide a recommended preferred needle shape to manufacturers to create a bespoke needle shape for a given patient and/or a recommended preferred needle shape for patient cohort having similar anatomy within the cohort.

Abstract: An apparatus and method for estimating one or more hemodynamic parameters such as cardiac output or stroke volume. Embodiments are based on the concept of incorporating information about vascular tone into hemodynamic parameter estimation to improve accuracy. More particularly, embodiments use a measurement of a time duration for a blood pulse to travel from the heart along a certain length of an arterial path as a proxy measure for vascular tone, and incorporate this into hemodynamic parameter estimation. Embodiments are also based on incorporating vascular tone proxy measurements for multiple different arterial paths to take account of vascular tone variations between different portions of the circulatory system.

Abstract: The present invention relates to a system for the controlled fragmentation of solids by means of acoustic beams, comprising at least one acoustic beam generation unit (100); and one feedback and control unit (200) of said generation unit (100). Advantageously, the acoustic beams generated by the system are acoustic vortex beams; and the feedback and control unit (200) further comprises a feedback subsystem (12), configured to receive the information relating to the fragmented solids and to utilize it so as to adapt the operation of the acoustic beam generation unit (100). Given that the generation of shearing stresses is more efficient using vortex beams, the amplitudes of the ultrasonic field needed to fragment the calculi are much lower than in current extracorporeal shock wave lithotripsy techniques. Likewise, the system minimizes unwanted effects on soft tissues surrounding the solid.

Abstract: According to one aspect of an exemplary embodiment of the disclosure, an imaging device or system, e.g., a mammography imaging system or device, includes a distance and location sensing system on the imaging system/e to provide accurate distance and position information from one or more sensing device(s) constituting the system that measure the elapsed time between the emission of the wave or radiation from the sensing device and the detection of the reflected wave or radiation. Examples of the types of sensing devices include ultrasound sensing devices, MEMS radar devices and time-of-flight (ToF) sensing devices. The distance information can be employed to determine the relative positions to produce a distance map illustrating the position and shape of any objects sensed within the zone by the sensing device(s), to determine the rate of change of the positions, i.e.

Abstract: A medical device includes a processor, an acceleration sensor, and memory. The acceleration sensor is configured to generate acceleration data that comprises a plurality of acceleration measurements. The memory comprises instructions that when executed by the processor, cause the processor to: obtain the acceleration data from the acceleration sensor; and determine, based on the acceleration data, that the medical device has flipped.

Abstract: Methods and systems for hyperthermia-based anti-cancer treatments are disclosed herein. One disclosed system for hyperthermia-based anti-cancer treatments includes an array of millimeter wave amplifier integrated circuits having an output energy, one or more medical grade implantable susceptors, and a beam steering controller for the array of millimeter wave amplifier integrated circuits that is configured to steer the output energy of the array of millimeter wave amplifier integrated circuits into the one or more medical grade implantable susceptors.

Abstract: A navigated surgery system includes at least one processor that is operative to obtain a 2D medical image slice of anatomical structure of a patient. The operations further obtain a 3D graphical model of anatomical structure. The operations determine a pose of a virtual cross-sectional plane extending through the 3D graphical model of the anatomical structure that corresponds to the anatomical structure of the 2D medical image slice. The operations control the XR headset to display the 2D medical image slice of the anatomical structure of the patient, display the 3D graphical model of the anatomical structure, and display a graphical object oriented with the pose relative to the 3D graphical model of the anatomical structure.

Abstract: A histotripsy therapy system configured for the treatment of brain tissue is provided, which may include any number of features. In one embodiment, the system includes an ultrasound therapy transducer, a drainage catheter, and a plurality of piezoelectric sensors disposed in the drainage catheter. The ultrasound therapy is configured to transmit ultrasound pulses into the brain to generate cavitation that liquefies a target tissue in the brain. The drainage catheter is configured to detect the ultrasound pulses. An aberration correction algorithm can be executed by the system based on the ultrasound pulses measured by the drainage catheter to automatically correct for an aberration effect caused by the ultrasound pulses passing through a skullcap of the patient.

Abstract: Perfusion angiography combined with photoplethysmography imaging for peripheral vascular disease assessment A device (13) and method for performing perfusion imaging receive image sequences that are acquired simultaneously by an X-ray imaging apparatus (2) and by a photoplethysmography imaging apparatus (3). When temporally aligned, changes in the perfusion states of a perfused organic tissue over time are extracted from the two image sequences and an image is generated for display on a display unit (5) which indicates the changes in the perfusion states at various locations of the perfused organ tissue, thereby capturing both deep organ tissue and superficial organ tissue perfusion properties. A diminution in an image signal strength in the photoplethysmography images caused by a passage of a bolus comprising a previously administered contrast agent (10) can be used to align the two concurrently acquired image sequences in time.

Abstract: An ultrasound imaging system configured to generate a 3D ultrasound image of a target area is disclosed herein. The ultrasound imaging system includes a console including one or more processors and non-transitory computer readable medium having stored thereon one or more logic modules. The ultrasound imaging system further includes an ultrasound probe, configured to acquire a plurality of ultrasound images of a target area, the ultrasound probe coupled to the console by an ultrasound probe connector having optical fiber including one or more core fibers, the ultrasound probe being a point of reference for the console to generate a three-dimensional visualization by stitching together the plurality of ultrasound images, starting from the point of reference.

Abstract: Ultrasound devices are disclosed. The ultrasound devices have an elevational dimension. Different percentages of the aperture of the ultrasound device corresponding to different percentages of the elevational dimension are utilized in different applications. The resolution of imagine may be adjusted in connection with usage of different percentages of the aperture.

Abstract: The present invention is directed to systems and process for detecting a febrile condition in screening of multiple or large groups of persons for the likelihood of infectious diseases. The system comprises a temperature measurement device having at least a processor, a display, temperature sensor, camera module, and facial recognition software. The display may include a positional overlay. The system further includes a database containing baseline temperatures for a number of persons, including baseline temperatures by age group and by gender. An input device optionally may identify the specific person or provide survey questions to a person to further determine a febrile condition. Based on the baseline temperatures, measured temperature and other characteristics of the person, a febrile condition may be determined. Additionally, the system may include a secondary screening component providing nasal swabbing or saliva testing.

Abstract: A system for determining relative positions of subsystems of a robot-assisted surgical system includes a subsystem component including a plurality of manipulator arms and a surgeon console. Each subsystem component includes at least one of an optical tracker and a light emitter. Image data from the optical trackers is analyzed to determine the relative positions of the subsystems.

Abstract: A system for determining characteristics of tissue within a body of a patient may include a medical device. The medical device may include a distal end configured to be advanced within the body of the patient; at least one aperture at the distal end; a laser emitter operable to emit monochromatic light out from the distal end via the at least one aperture and onto target tissue; and at least one photodetector array. The at least one photodetector array may be configured to: receive light incident on the at least one aperture that is one or more of scattered by or reflected from the target tissue; and generate Raman spectroscopy image data based on monochromatic light incident on the at least one aperture, the Raman spectroscopy image data including an array of intensity values.

Abstract: For a receiving surface coil for detecting nuclear magnetic resonance signals from a patient, a solution for an easy adaptation of the receiving surface coil to the anatomy of the patient is disclosed. This is achieved by a receiving surface coil for detecting nuclear magnetic resonance signals from a patient, the receiving surface coil comprising: a flexible housing with an opening, a set of RF loop elements housed in the flexible housing, wherein the set of RF loops comprises at least a central loop element running around the opening in the flexible housing and a number of loop elements arranged around the opening.

Abstract: To set parameters according to a body part of interest serving as a target for producing a color Doppler image, a processor in an ultrasonic image display system identifies a body part of interest serving as a target for producing a color Doppler image of a patient based on data for a B-mode image, and determines parameters regarding acquisition of data for the color Doppler image according to the body part of interest. The processor then controls an ultrasonic probe to perform a color Doppler scan for a color Doppler image on the patient using the determined parameters, and creates data for a color Doppler image based on echo data obtained by the color Doppler scan.

Abstract: A method of treating cancer is disclosed. The method involves applying one or more direct current electric fields (DC-EFs) to a subject and administering to the subject an additional treatment selected from the group consisting of radiation, an effective amount of one or more chemotherapy agents, SapC-DOPS, anti-phosphatidylserine targeted drugs, and combinations thereof.

Abstract: A cover member includes: a sheath that is formed in a cylindrical shape for receiving a shaft; and a tubular portion that is attached to a distal end of the sheath. The tubular portion being formed such that an outer dimension of a distal end portion of the tubular portion in a first direction is smaller than an outer dimension of a proximal end portion of the tubular portion in the first direction and/or an outer dimension of the distal end portion in a second direction is smaller than an outer dimension of the proximal end portion in the second direction.

Abstract: A system and method for performing an automated medical procedure is provided. The method may include positioning an effector unit over a patient, acquiring medical imagery of the patient, analyzing the medical imagery using at least one processor to determine a location, and positioning a subunit of the effector unit to perform the automated medical procedure at the location. The automated medical procedure may be performed using at least one of a plurality of subunits of the effector unit. The automated medical procedure may be a body fluid aspiration procedure and one of the plurality of subunits of the effector unit may include a fluid aspirating cannula. Multiple subunits may be sequentially used to perform the procedure.

Abstract: Provided herein are, inter alia, methods for identifying subjects suffering from depression that will respond to treatment with an antidepressant.