Abstract: A continuous glucose monitoring (CGM) device may include a wearable portion having a sensor configured to produce glucose signals from interstitial fluid, a processor, a memory and transmitter circuitry. The memory may include a pre-determined gain function based on a point-of-interest glucose signal and glucose signals measured prior to the point-of-interest glucose signal. The memory may also include computer program code stored therein that, when executed by the processor, causes the CGM device to (a) measure and store a plurality of glucose signals using the sensor and memory; (b) for a presently-measured glucose signal, employ the plurality of previously-measured glucose signals stored in the memory and the pre-determined gain function to compute a compensated glucose value; and (c) communicate the compensated glucose value to a user of the CGM device. Numerous other embodiments are provided.

Abstract: Devices for sampling gastro-intestinal material are disclosed. In one arrangement a device comprises a capsule body that has a sample input valve. A suction mechanism is provided that is capable of generating a partial vacuum within the capsule body and thereby drawing gastro-intestinal material into the capsule body through the sample input valve. An actuator actuates the suction mechanism. The actuator comprises a dissolvable element and is configured so that the dissolvable element dissolves in a predetermined region of the gastro-intestinal tract and the dissolving of the dissolvable element causes actuation of the suction mechanism. The suction mechanism comprises a biasing member restrained by the dissolvable element prior to actuation of the suction mechanism. The dissolving of the dissolvable element releases the biasing member. The biasing member expands a sample chamber within the capsule body on release of the biasing member, and generates the partial vacuum within the capsule body.

Abstract: Pre-connected analyte sensors are provided. A pre-connected analyte sensor includes a sensor carrier attached to an analyte sensor. The sensor carrier includes a substrate configured for mechanical coupling of the sensor to testing, calibration, or wearable equipment. The sensor carrier also includes conductive contacts for electrically coupling sensor electrodes to the testing, calibration, or wearable equipment.

Abstract: Devices and methods are described herein for directly and accurately measuring sweat flow rates using miniaturized thermal flow rate sensors. The devices (100, 200, 300, 400, 500, 600, 700, 800, 900, 1000, 1100, 1200, 1300, 1400, 1500) include the flow rate sensors (220, 320, 420, 520, 620, 720, 820, 920, 1020, 1120, 1220, 1320, 1420) in or adjacent to a microfluidic component (230, 330, 430, 530, 630, 730, 830, 930, 1030, 1130, 1230, 1330, 1430, 1530) of a wearable sweat sensing device. The devices and methods optimize the sensitivity of the flow rate sensors, while minimizing the presence of noise, in order to accurately and directly measure sweat flow rates.

Abstract: The present invention discloses a holder carrying thereon a sensor to measure a physiological signal of an analyte in a biological fluid, wherein the sensor has a signal detection end and a signal output end, and the holder includes an implantation hole being a channel for implanting the sensor and containing a part of the sensor, a fixing indentation containing the sensor, a filler disposed in the fixing indentation to retain the sensor in the holder, and a blocking element disposed between the implantation hole and the fixing indentation to hold the sensor in the holder and restrict the filler in the fixing indentation.

Abstract: A blood pressure measuring apparatus, may include: a touch sensor; a pulse wave measurer configured to measure pulse waves from a user's finger when the user's finger is in contact with the touch sensor; a contact pressure measurer configured to measure a contact pressure between the user's finger and the touch sensor; a fingerprint recognizer configured to recognize a fingerprint of the user's finger; and a processor configured to determine a degree of position coincidence between the user's finger and the pulse wave measurer based on the recognized fingerprint, and to estimate a blood pressure of the user based on the pulse waves and the contact pressure according to the determined degree of position coincidence.

Abstract: Conformable and wearable sensors with integrated on-chip gate for the detection of biomolecules, chemicals, and other substrates and applications thereof are provided. Biosensor chips can be built with In2O3 nanoribbon field-effect transistors. Biosensor chips can conform to features of a human body, enabling ability for individuals to wear a biosensor.

Abstract: A sensor includes: a tubular needle member that includes a side wall and defines a hollow portion; and a linear detection member located in the hollow portion. The side wall of the needle member includes a thick portion that is thicker than another portion of the side wall in a cross-section of the needle member, and wherein the thick portion protrudes toward the hollow portion.

Abstract: A biosensor for measuring a physiological signal representative of a physiological parameter associated with an analyte is described. The biosensor includes a working electrode and a counter electrode. The counter electrode including a silver and a silver halide having an initial amount, wherein the initial amount is determined by the following steps of defining a required consumption range of the silver halide during at least one of the measurement periods performed by the biosensor; and determining the initial amount based on a sum of an upper limit of the required consumption range and a buffer amount, so that a required replenishment amount range of the silver halide during the replenishment period is controlled to be sufficient to maintain an amount of the silver halide within a safe storage range.

Abstract: Systems, methods, and devices of a health device network may include: a non-invasive glucometer that non-invasively measures analyte levels; an invasive glucometer communicatively coupled directly to the non-invasive glucometer; a cloud-based server communicatively coupled to the non-invasive glucometer or the invasive glucometer; a user device communicatively coupled to the cloud-based server; and/or a user interface that displays the invasive glucose measurement, the non-invasive glucose measurement, a data batch, and/or processed data to the user. The non-invasive glucometer and/or the invasive glucometer may aggregate an invasive glucose measurement and a non-invasive glucose measurement into the data batch.

Abstract: The present invention discloses a holder carrying thereon a sensor to measure a physiological signal of an analyte in a biological fluid, wherein the sensor has a signal detection end and a signal output end, and the holder includes an implantation hole being a channel for implanting the sensor and containing a part of the sensor, a containing indentation containing the signal output end, a fixing indentation fixing thereto the sensor and communicating with the containing indentation, a waterproof seal disposed above the implantation hole, an elastic divider disposed in the implantation hole to separate the implantation hole and covering all over a cross-sectional area of the implantation hole, and a blocking element disposed between the implantation hole and the fixing indentation to hold the sensor.

Abstract: The present invention discloses a holder carrying thereon a sensor to measure a physiological signal of an analyte in a biological fluid, wherein the sensor has a signal detection end and a signal output end, and the holder includes an implantation hole being a channel for implanting the sensor and containing a part of the sensor, a waterproof seal disposed above the implantation hole, and an elastic divider disposed in the implantation hole to separate the implantation hole and covering all over a cross-sectional area of the implantation hole.

Abstract: A device including an array of electrodes generates one or more electrical signals from a user, extracts one or more noise signals, and generates one or more de-noised electrical signals upon processing the electrical signal(s) with the noise signal(s). The array of electrodes is coupled to a surface of the device, where the device also includes force sensors in mechanical communication with the surface for detecting user weight and other forces. The device can be configured to generate electrical signals from different subportions of the array of electrodes and to extract noise signals from different subportions of the array of electrodes, where the subportion(s) for electrical signal generation may or may not overlap with the subportion(s) of electrodes for noise signal extraction.

Abstract: A system may include a first device and a second device. The second device may be configured to execute an application and validate that the application is able to cause the second device to (i) communicate with the first device and (ii) communicate with a user of the second device. The second device may be configured to (a) check one or more settings of the second device and/or (b) convey a request for data to the first device and determine whether the second device receives the requested data. The second device may be configured to cause the second device to display a message requesting confirmation that the second device displayed the message and determine whether the second device receives the requested confirmation that the second device displayed the message.

Abstract: A sensing chip attached to a bandage monitors the healing process of a wound by detecting growth factors, thrombin and fibrinogen. The complementary metal-oxide semiconductor includes a functionalized working electrode, functionalized counter electrode and functionalized reference electrode. The healing progress is stimulated by generating oxygen in the wound.

Abstract: A pressure compensating non-invasive blood-component measuring device has electrically insulated parallel electrodes mounted on a dielectric membrane (106). A main circuit board (201) provides electrical connections to the electrodes and has an orifice (402) to allow flexing. A housing supports the main circuit board, with a second orifice to facilitate the application of a finger onto the insulated electrodes. A bottom circuit board (401) supports a force sensor (408) and fixing elements (313, 314) secure the bottom circuit board to the top circuit board, such that the bottom circuit board does not contact the housing directly. An intermediate board (316) is guided but not restrained by the fixing elements, and is arranged to apply force onto said force sensor.

Abstract: A computer-implemented method for analyzing glucose monitoring data comprising: receiving first glucose monitoring data indicative of a glucose level at a measurement time, the first glucose monitoring signals detected in one or more glucose measurement time periods over a first monitoring time period of a continuous glucose monitoring, determining at least one first range event selected from the following group: a normal glucose level event, a hyperglycaemia event, or a hypoglycaemia event; determining how often the first range event is determined for the first monitoring time period; providing a first minimum total, measurement time period, the first minimum total measurement time period being shorter in time than the first monitoring time period; generating first display data representing, for the at least one first range event, the number of first range events in a graphical representation, if the one or more glucose measurement time periods sum up to at least a first minimum total measurement time period

Abstract: An oxygen sensor for sensing dissolved oxygen concentration in tissue includes an electrochemical sensor comprising first and second conductive threads having proximal sections connected to a potentiostat. The first thread forms a cathode, and the second thread forms an anode.

Abstract: Systems, methods, and devices of a health device network may include: a non-invasive glucometer that non-invasively measures analyte levels; an invasive glucometer communicatively coupled directly to the non-invasive glucometer; a cloud-based server communicatively coupled to the non-invasive glucometer or the invasive glucometer; a user device communicatively coupled to the cloud-based server; and/or a user interface that displays the invasive glucose measurement, the non-invasive glucose measurement, a data batch, and/or processed data to the user. The non-invasive glucometer and/or the invasive glucometer may aggregate an invasive glucose measurement and a non-invasive glucose measurement into the data batch.

Abstract: Wearable medical devices are provided. An exemplary wearable medical device includes a printed circuit board assembly (PCBA) comprising a dielectric layer having a top surface and conductive features on the top surface of the dielectric layer. Further, the exemplary wearable medical device includes a top housing mounted directly to the top surface of the PCBA. Also, the wearable medical device includes a power source located between the top housing and the PCBA. The top housing and the dielectric layer of the PCBA encapsulates the conductive features and power source and define an outer surface of the wearable medical device.