Abstract: A method for the augmentation of immune function is described. The invention comprises a combination of ?-1,3 (4)-endoglucanohydrolase, ?-1,3 (4)-glucan, diatomaceous earth, mineral clay and glucomannan, which is fed to or consumed by mammalian or avian species in amounts sufficient to augment immune function. The invention described may be admixed with feeds or foods, incorporated into pelleted feeds or foods or administered orally to mammalian and avian species.
Abstract: Hydrolyzed collagen type II powder compositions for inducing cartilage formation in an individual, method of preparing the compositions and use of the compositions in treating connective tissue disorder, replenishing skin viscoelasticity. The compositions are administered through an orally ingestible delivery medium for absorption into the gastrointestinal tract. The compositions are administered through a topical delivery medium for absorption into a dermis of the individual.
Abstract: The invention provides methodologies and apparatus for producing devitalized soft-tissue implants where the implant retains metabolically non-viable and/or reproductively non-viable cells, and preferably retains large molecular weight cytoplasmic proteins, such implants produced both in small quantities and in commercializable quantities. Such soft-tissue implants include vascular graft substitutes. A devitalized graft is produced by subjecting the tissue sample to an induced pressure mediated flow of an extracting solution, optionally followed by inducing a pressure mediated flow of a salt solution, then washing the tissue to produce the devitalized graft. The devitalized grafts produced are uniform and non-immunogenic. The inventive method allows for the production of multiple devitalized soft tissue implants, where processing time is significantly less than prior art processes and the number of implants produced per day is increased over prior art processes.
Type:
Grant
Filed:
October 28, 2003
Date of Patent:
October 22, 2013
Assignee:
LifeNet Health
Inventors:
Lloyd Wolfinbarger, Jr., Perry Lange, Alyce Linthurst-Jones, Eric Moore, Barry Nolf
Abstract: A cardiovascular support composition is provided comprising red yeast rice, Coenzyme-Q10, and phytosterols. A method for maintaining cardiovascular health is also provided comprising administering the composition comprising red yeast rice, Coenzyme-Q10, and phytosterols in a predefined dosage to an individual in need thereof.
Abstract: The invention relates to a novel strain of Lactobacillus paracasei subspecies paracasei, having antimicrobial and immunomodulatory properties, and to compositions containing said strain.
Type:
Grant
Filed:
April 16, 2009
Date of Patent:
October 15, 2013
Assignee:
Compagnie Gervais Danone
Inventors:
Isabelle Chambaud, Artem Khlebnikov, Anne-Catherine Villain, Gianfranco Grompone, Thierry Saint Denis, Anne Druesne, Tamara Smokvina
Abstract: A method and an apparatus are described for infiltrating tissue samples with carrier material, preferably paraffin. A supply of carrier material is kept ready for use in a supply station. From there, the carrier material can be delivered into at least a first and a second container. In these first and second containers carrier materials of differing degrees of purity are kept ready for use, respectively, for performing various infiltration steps on tissue samples. By means of the described method and apparatus the tissue processor can be operated with as little interruptions as possible and an ease in operation is achieved.
Type:
Grant
Filed:
August 17, 2009
Date of Patent:
October 15, 2013
Assignee:
Leica Instruments (Singapore) Pte. Ltd.
Inventors:
Hermann Ulbrich, Michael Rapp, Marc Konrad, Holger Metzner, Markus Dobusch, Eva Goedecke, Stefan Kuenkel, Udo Herrmann
Abstract: Provided is a method of separating microorganisms from a sample including contacting the sample containing microorganisms with an inorganic on exchange material such that the sample reacts with the inorganic on exchange material, and contacting the reacted sample with a means for capturing microorganisms.
Type:
Grant
Filed:
December 14, 2011
Date of Patent:
October 15, 2013
Assignee:
Samsung Electronics Co., Ltd.
Inventors:
Kyu-youn Hwang, Sung-young Jeong, Joon-ho Kim
Abstract: The invention is a reverse-flow method and system for the loading, proliferation and differentiation of cells into and throughout an implantable biocompatible three-dimensional scaffold.
Type:
Grant
Filed:
March 4, 2005
Date of Patent:
October 1, 2013
Assignee:
Millenium Biologix Technologies Inc.
Inventors:
Ivan Martin, David Wendt, Alessandra Braccini, Rodolfo Quatro, Marcel Jakob
Abstract: Provided herein are keratin compositions useful for treating ischemia and/or reperfusion injury, such as that associated with myocardial infarct, ischemic stroke, brain trauma such as traumatic brain injury, hypothermia, chronic wounds, and burns.
Type:
Grant
Filed:
March 8, 2011
Date of Patent:
October 1, 2013
Assignee:
Wake Forest University Health Sciences
Inventors:
Mark E. Van Dyke, Thomas L. Smith, Michael Callahan, Luke Burnett
Abstract: Methods and compositions for detection of microbial contaminants in peritoneal dialysis solutions are provided. The methods and compositions employ modified bioburden testing and the detection of peptidoglycan. A novel cause of aseptic peritonitis is provided—aseptic peritonitis associated with gram positive microbial contamination of a dialysis solution. Peptidoglycan is a major component of a gram positive bacterial cell wall and thus can serve as a marker for gram positive bacteria. In this regard, testing for peptidoglycans can be utilized to effectively prevent peritonitis in patients that use the peritoneal dialysis solutions, such as peritoneal dialysis solutions that contain a glucose polymer including an icodextrin and the like.
Type:
Grant
Filed:
November 13, 2009
Date of Patent:
October 1, 2013
Assignees:
Baxter International Inc., Baxter Healthcare S.A.
Inventors:
Leo Martis, Mehul Patel, Joseph A. Giertych, James W. Mongoven, Jacqueline A. Kunzler, William F. Owen, Jr.
Abstract: Disclosed are tissue graft compositions made of materials having different densities, methods of making, and methods of treatment for restoring tissues in a patient.
Abstract: A modified reconstituted extracellular matrix composition is provided herein. The composition includes an extracellular matrix and at least one exogenous component selected from heparin, fibronectin and laminin. The composition may have a basic pH. Additionally, provided herein is a cell culturing system including a substrate and a coating thereon of the composition to assess potential stimulators and/or inhibitors for their effects on various cell cultures while increasing the signal dynamic range.
Abstract: Provided herein is a biohybrid elastomeric scaffold comprising a synthetic polymeric component and a biological polymeric component. The scaffold can be fabricated to have many different forms, non-limiting examples of which include a non-woven fibrous mesh or in a porous composite. Methods of use of the biohybrid elastomeric scaffolds in wound healing and tissue regeneration are also provided.
Type:
Grant
Filed:
July 6, 2007
Date of Patent:
September 17, 2013
Assignee:
University of Pittsburgh - Of the Commonwealth System of Higher Education
Inventors:
Stephen F. Badylak, Donald O. Freytes, Thomas W. Gilbert, Jianjun Guan, John Stankus, William R. Wagner
Abstract: Blood-derived plastic articles prepared from compositions including blood and, in some embodiments, at least one crosslinking agent and/or at least one biological response modifier, that can be useful for biological applications such as wound repair and tissue grafts; methods of making and using the same; methods for assessing the concentration of a biological response modifier in an article; and systems for preparing blood-derived plastic articles are provided.
Type:
Grant
Filed:
July 6, 2011
Date of Patent:
September 10, 2013
Assignees:
Carnell Therapeutics Corporation, Allegheny-Singer Research Institute, Carnegie Mellon University
Inventors:
Phil G. Campbell, James E. Burgess, Lee E. Weiss, Jason Smith
Abstract: Blood-derived plastic articles prepared from compositions including blood and, in some embodiments, at least one crosslinking agent and/or at least one biological response modifier, that can be useful for biological applications such as wound repair and tissue grafts; methods of making and using the same; methods for assessing the concentration of a biological response modifier in an article; and systems for preparing blood-derived plastic articles are provided.
Type:
Grant
Filed:
April 17, 2008
Date of Patent:
September 10, 2013
Assignees:
Carnell Therapeutics Corporation, Carnegie Mellon University, Allegheny-Singer Research Institute
Inventors:
Phil G. Campbell, James E. Burgess, Lee E. Weiss, Jason Smith
Abstract: Blood-derived plastic articles prepared from compositions including blood and, in some embodiments, at least one crosslinking agent and/or at least one biological response modifier, that can be useful for biological applications such as wound repair and tissue grafts; methods of making and using the same; methods for assessing the concentration of a biological response modifier in an article; and systems for preparing blood-derived plastic articles are provided.
Type:
Grant
Filed:
July 6, 2011
Date of Patent:
September 10, 2013
Assignees:
Carmell Therapeutics Corporation, Allegheny-Singer Research Institute, Carnegie Mellon University
Inventors:
Phil G. Campbell, James E. Burgess, Lee E. Weiss, Jason Smith
Abstract: Blood-derived plastic articles prepared from compositions including blood and, in some embodiments, at least one crosslinking agent and/or at least one biological response modifier, that can be useful for biological applications such as wound repair and tissue grafts; methods of making and using the same; methods for assessing the concentration of a biological response modifier in an article; and systems for preparing blood-derived plastic articles are provided.
Type:
Grant
Filed:
July 6, 2011
Date of Patent:
September 10, 2013
Assignees:
Carmell Therapeutics Corporation, Allegheny-Singer Research Institute, Carnegie Mellon University
Inventors:
Phil G. Campbell, James E. Burgess, Lee E. Weiss, Jason Smith
Abstract: Blood-derived plastic articles prepared from compositions including blood and, in some embodiments, at least one crosslinking agent and/or at least one biological response modifier, that can be useful for biological applications such as wound repair and tissue grafts; methods of making and using the same; methods for assessing the concentration of a biological response modifier in an article; and systems for preparing blood-derived plastic articles are provided.
Type:
Grant
Filed:
July 6, 2011
Date of Patent:
September 10, 2013
Assignees:
Carmell Therapeutics Corporation, Allegheny-Singer Research Institute, Carnegie Mellon University
Inventors:
Phil G. Campbell, James E. Burgess, Lee E. Weiss, Jason Smith
Abstract: The present invention provides methods of determining a characteristic of a cell, such as cell type, cellular response to a biochemical event, and biological state. The method generally involves detecting membrane movement in a cell to determine a characteristic of a cell. The methods of the invention are useful for applications such as drug screening and diagnostics. The invention further provides databases of cell characteristics, as determined by the instant methods. The invention further provides systems for determining the characteristic of a cell.
Type:
Grant
Filed:
March 9, 2005
Date of Patent:
September 3, 2013
Assignee:
The Regents of the University of California