Abstract: The present invention relates to a lactase solution comprising a lactase solution comprising less than 10 g/kg of poly and oligosaccharides, a process for the production of such a lactase solution from an untreated lactase solution, a sterilized lactase, whereby such lactose is filter sterilized in-line with the milk production process.
Type:
Grant
Filed:
May 5, 2011
Date of Patent:
October 6, 2015
Assignee:
DSM IP ASSETS B.V.
Inventors:
Rudolf Franciscus Wilhelmus Cornelis Van Beckhoven, Petrus Andreas Van Paridon
Abstract: A composition of lysozyme and a pharmaceutically acceptable carrier is active against the papilloma virus in both humans and animals. The composition can be used to treat women suffering from cervical cancer. The composition can also be used to treat cows and horses suffering sarcoids.
Abstract: Biologically pure cultures of Bacillus subtilis were isolated from the pericarp of nixtamalized corn. The Bacillus microorganisms were characterized and found to produce novel peptides which have antimicrobial activity. The Bacillus microorganisms are active against Gram-positive bacteria and may be used as an agent to prevent spoilage in foods. The Bacillus microorganisms may be included in probiotic food compositions to help maintain healthy gastrointestinal flora and modulate animal digestion.
Type:
Grant
Filed:
September 14, 2011
Date of Patent:
September 29, 2015
Assignee:
INVESTIGACION DE TECNOLOGIA AVANZADA, S.A. DE C.V.
Inventors:
Felipe A. Rubio, Manuel J. Rubio, Roberto Contreras, J. Fernando Ramirez
Abstract: Various embodiments of the invention provide methods of treating diabetes and other glucose regulation disorders. In one embodiment, the method comprises removing L-cells from a donor, obtaining stem cells from a patient, and culturing the L-cells in the presence of the stem cells under conditions such that the stem cells differentiate into stem cell-derived L-cells (SCDLC). An amount of the SCDLC is introduced into the patient sufficient to cause a lowering of the patient's blood glucose level after ingestion of food. In another embodiment, the method comprises removing K-cells from a donor, obtaining stem cells from a patient, and culturing the K-cells in the presence of the stem cells under conditions such that the stem cells differentiate into stem cell-derived K-cells (SCDKC). An amount of the SCDKC is introduced into the patient sufficient to cause a lowering of the patient's blood glucose level after ingestion of food.
Abstract: The present invention relates to a composition for suppressing the death of stem cells during suspension culturing, a composition for mass culturing of stem cells, and a method for suppressing cell death of stem cells during suspension culturing. The composition of the present invention can be usefully used for effective single suspension culturing of stem cells, particularly, mesenchymal stem cells, or used for mass suspension culturing under the circumstances in which cell aggregation does not occur.
Abstract: The purpose of the present invention is to provide, in a simple and also inexpensive manner, a pharmaceutical composition which comprises a plurality of lysosomal enzymes and is effective in treating lysosomal storage disease caused by a deficiency in a plurality of lysosomal enzymes. Provided is a pharmaceutical composition for treating lysosomal storage disease, the composition comprising as an active ingredient a lysosomal enzyme group obtained from cells derived from a subject who does not suffer from lysosomal storage disease.
Abstract: A method of sex sorting sperm is disclosed. The sperm may be stained with a DNA selective fluorescent dye, which fluoresces when excited, a dead quenching dye, which selectively quenches fluorescence emitted by the DNA selective fluorescent dye within the membrane of compromised sperm, and a split enhancing dye. The stained sperm may then sorted into one or more gender enriched subpopulations of viable sperm.
Type:
Grant
Filed:
September 28, 2012
Date of Patent:
September 22, 2015
Assignee:
Inguran, LLC
Inventors:
Kenneth Michael Evans, Thomas B. Gilligan, Clara Gonzalez-Marin
Abstract: This application relates to a serum-free culture medium that enables the proliferation of cell of the myogenic lineage while maintaining their ability to differentiate into functional muscle cells. Also contemplated herewith are method of culturing cells of the myogenic lineages and uses of the cultured cells for the treatment or the alleviation of symptoms of a muscular deficiencies.
Type:
Grant
Filed:
September 22, 2009
Date of Patent:
September 22, 2015
Assignee:
Universite Laval
Inventors:
Victor-Alain Parent, Alain Garnier, Jacques P. Tremblay
Abstract: Acellular amnion derived therapeutic compositions are described having a number of various compositional embodiments. An acellular amnion derived therapeutic composition has essentially no live or active amniotic stems cells. The amniotic stem cells may be destroyed, and the cells and cell debris may be removed from the acellular amnion derived therapeutic composition. An acellular amnion derived therapeutic composition may comprise micronized amniotic membrane particles, and/or amniotic fluid. An acellular amnion derived therapeutic composition may be a dispersion of micronized amniotic membrane combined with a fluid, such as plasma, saline, amniotic fluid, combinations thereof and the like. An acellular amnion derived therapeutic composition may be combined with a matrix component to form a composite. An acellular amnion derived therapeutic composition may be used in conjunction with a composition comprising viable cells, such as stem cells.
Type:
Grant
Filed:
January 9, 2015
Date of Patent:
September 15, 2015
Inventors:
Bruce Werber, Christian Beaudry, Terrell Suddarth
Abstract: The invention provides a method of treating a disorder characterized by elevated or dysregulated myostatin, disorders where the interaction between follistatin and angiogenin can be used to improve function in tissues, neurological diseases or disorders, spinal injuries or diseases, bone diseases or disorders, diseases involving glucose homeostasis, wound healing, neuroprotection, nervous system functional support or managing metabolic diseases, the method comprising administering an effective amount of angiogenin or an angiogenin agonist. Compositions and neutraceuticals comprising angiogenin are also provided.
Abstract: Compositions and processes for the effective and efficient regeneration of spinal discs are provided. These compositions contain stem cells, donor cells, and platelet plasma compositions. By using these compositions, there is an increased likelihood of acceptance and proper cell differentiation.
Abstract: The present invention provides methods for manufacturing heat treated products involving the use of probiotic bacteria, e.g. lactic acid bacteria and/or Bifidobacteria, cultures of such bacteria, supernatant from such cultures, and/or concentrates of such supernatant and/or fractions of such supernatant. The invention further provides heat treated products of such processes and their use for regulation of cellular uptake of fat and/or triglycerides and/or body weight management or weight reduction and/or redistribution of fat and/or reduction in visceral and/or abdominal fat deposition in a subject.
Type:
Grant
Filed:
December 5, 2008
Date of Patent:
August 25, 2015
Assignee:
Arla Foods amba
Inventors:
Velmurugesan Arulampalam, Joseph James Rafter, Sven Pettersson
Abstract: A demineralized bone matrix is produced by a process in which a bone body is placed in a first processing solution comprising an acid to demineralize the bone body. The bone body is periodically removed from the first solution at specific time intervals to perform at least one test, such as a compression test, on a mechanical property of the bone body. When the test yields a desired result, the bone body is exposed to a second processing solution that is less acidic than the first, thus minimizing the exposure of the bone body to the harsh acidic conditions of the demineralization phase of the process.
Type:
Grant
Filed:
February 21, 2014
Date of Patent:
August 25, 2015
Assignee:
Bacterin International, Inc.
Inventors:
Nancy J. Shelby, Steven M. Scott, Benjamin P. Luchsinger, Gregory A. Juda, Kelly R. Kirker, Darrel L. Homes, Jesus Hernandez
Abstract: The invention provides for a method for aggregating dermal papilla cells or dermal sheath cells or a combination thereof, the method comprising: growing dermal papilla cells or dermal sheath cells or a combination thereof in suspension culture; and contacting the culture with an effective amount of an enzyme, wherein a substrate of the enzyme is an extracellular matrix molecule in the suspension culture, so as to aggregate dermal papilla cells or dermal sheath cells. The culture may be a hanging drop culture and the enzyme may be a hyaluronidase.
Type:
Grant
Filed:
February 28, 2007
Date of Patent:
August 18, 2015
Assignees:
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, DURHAM UNIVERSITY
Inventors:
Angela M. Christiano, Colin A. B. Jahoda
Abstract: The present invention is directed to methods of diagnosing and treating a fibrotic condition in a mammalian subject. These methods involve measuring the levels of trimethylation at lysine residue 27 of histone-3 and/or measuring the expression levels of EZH2 or YY-1. Agents useful for treating fibrosis or a fibrotic condition are also disclosed.
Type:
Grant
Filed:
November 2, 2009
Date of Patent:
August 18, 2015
Assignee:
University of Rochester
Inventors:
Jia Guo, Xin Lin, Steve Georas, Patricia Sime
Abstract: A method of preserving organisms in viable form, the method comprising: suspending organisms in a solution of electrospinnable polymer; drawing droplets of said solution through a spinneret; applying an electrostatic field to said droplets under electrospinning conditions; so as to form fibers having a diameter no greater than about 5 ?m within which distinct organisms are encapsulated in viable form.
Type:
Grant
Filed:
August 29, 2007
Date of Patent:
August 4, 2015
Assignee:
Technion Research & Development Foundation Limited
Abstract: A first cell containing at least one magnetic particle is provided and a second cell is also provided. The second cell is cultured in the presence of the first cell. An alternating magnetic field is applied to the first cell. The alternating magnetic field at least partially separates the first cell from the second cell.
Abstract: The present invention relates to a method for processing a wax-embedded biological sample, the use of poly(organosiloxane)s for liquefying the embedding medium of a wax-embedded biological sample and a kit for processing a wax-embedded biological sample.
Abstract: A method is provided to functionally select cells with enhanced characteristics relevant to cell engraftment, including both spontaneous migration and directional migration towards specific chemo-attractants. The cells are preferably undifferentiated cells, such as mesenchymal stem cells. The method involves entrapping or encapsulating the cells in a biomaterial barrier, optionally inducing cell migration, and selecting cells that migrated through the barrier. The cells selected by this method have better migratory activities and enhanced in vivo engraftment to injured tissues when they are supplemented systemically.
Type:
Grant
Filed:
June 14, 2011
Date of Patent:
August 4, 2015
Assignee:
Versitech Limited
Inventors:
Barbara Pui Chan, Hoi Ling Wong, Mei Yi Wong, Godfrey Chi-Fung Chan, Zhen Fan Yang