Patents Examined by Allison M. Ford
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Patent number: 8574554Abstract: The present invention relates to the use of 4-methyl-delta-hexylactone for imparting, modifying and/or intensifying one or more smell or flavor impressions from the group consisting of hay, coumarin, lactone and richness in the mouth.Type: GrantFiled: April 18, 2007Date of Patent: November 5, 2013Assignee: Symrise AGInventors: Günter Kindel, Bernd Wiedwald, Axel Schöning, Ingo Wöhrle, Hubert Loges, Rita Lages
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Patent number: 8372439Abstract: Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.Type: GrantFiled: August 7, 2012Date of Patent: February 12, 2013Assignee: Mimedx Group, Inc.Inventors: John Daniel, Robert Tofe, Randall Spencer, John Russo
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Patent number: 8298810Abstract: A method of making a molded part, including adding a fungal inoculum with a liquid aggregate to form a mixture. The mixture is inserted into a mold cavity. The mold cavity is covered with a cover. Live mycelium is grown from the mixture that fills the mold cavity and physically couples with the cover. The live mycelium is heated to terminate further growth and develop a composite component made of mycelium and the cover.Type: GrantFiled: June 9, 2010Date of Patent: October 30, 2012Assignee: Ford Global Technologies, LLCInventors: Charles Alan Rocco, Raymond Edward Kalisz
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Patent number: 8076123Abstract: This invention relates to an oil degumming method that is free of emulsification. This method includes the steps of treating crude oil first with immobilized phospholipase and then extracting the phospholipase-treated crude oil with pure water or an aqueous solution.Type: GrantFiled: October 26, 2007Date of Patent: December 13, 2011Assignee: Oilseeds Biorefinery CorporationInventor: Chih-chung Chou
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Patent number: 8071318Abstract: Drug candidate screening methods are applied to discover compounds with activity against ion channel targets. The method may include modulating the transmembrane potential of host cells in a plurality of sample wells with a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.Type: GrantFiled: February 2, 2004Date of Patent: December 6, 2011Assignee: Vertex Pharmaceuticals (San Diego) LLCInventors: Michael P. Maher, Jesus E. Gonzalez, III
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Patent number: 8062868Abstract: An electrically conductive cellulose composite includes a cellulose matrix and an electrically conductive carbonaceous material incorporated into the cellulose matrix. The electrical conductivity of the cellulose composite is at least 10 ?S/cm at 25° C. The composite can be made by incorporating the electrically conductive carbonaceous material into a culture medium with a cellulose-producing organism, such as Gluconoacetobacter hansenii. The composites can be used to form electrodes, such as for use in membrane electrode assemblies for fuel cells.Type: GrantFiled: March 22, 2010Date of Patent: November 22, 2011Assignee: UT-Battelle, LLCInventors: Barbara R. Evans, Hugh M. O'Neill, Jonathan Woodward
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Patent number: 8063181Abstract: The invention at hand describes a method for the cyclization of peptides and proteins in which linear thioesters serve as substrates. The cyclization is catalyzed by thioesterase domains of NRPS or PKS cyclases. The substrates according to the present invention are composed of one linear peptide on which a charge-stabilized aromatic, heteroaromatic or araliphatic leaving group is bound. These substrates lead to higher yields and reaction rates than linear peptides able to be cyclized with methods known so far and, furthermore, allow the cyclization of such peptides which were previously not able to be cyclized.Type: GrantFiled: July 30, 2004Date of Patent: November 22, 2011Assignee: ZYRUS Beteiligungsgesellschaft mbH & Co. Patent I KGInventors: Mohamed A. Marahiel, Stephan Sieber
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Patent number: 8058056Abstract: Method and systems provide improved cell handling in microfluidic systems and devices using lateral cell trapping and methods of fabrication of the same that allow for selective low voltage electroporation and electrofusion.Type: GrantFiled: August 21, 2006Date of Patent: November 15, 2011Assignee: The Regents of the University of CaliforniaInventors: Luke P. Lee, Jeonggi Seo, Cristian Ionescu-Zanetti, Michelle Khine, Adrian Lau
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Patent number: 8048043Abstract: The present invention concerns a method for treating a respiratory distress in a infant in need of such treatment, the method comprising intratracheal administration of a pulmonary surfactant by a thin tube. The invention also concerns a kit for performing said method.Type: GrantFiled: June 8, 2007Date of Patent: November 1, 2011Assignee: Chiesi Farmaceutici S. P. A.Inventors: Egbert Herting, Wolfgang Gopel, Paolo Chiesi
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Patent number: 8017314Abstract: The invention relates to measuring the concentration of analytes with the aid of an oxidase in an immersion sensor situated in a fluid or in a matrix containing fluid. Oxygen diffuses into the enzyme layer from within, from a gas-filled space connected to the atmosphere and/or to an oxygen reservoir. This enables oxygen saturation of the oxidase in a low-oxygen or oxygen-free medium and/or at high analyte concentrations. The analyte diffuses into the enzyme layer in a channel or a number of channels which contain(s) water and limit(s) diffusion, wherein the channel/channels on the surface of the sensor is/are filled with a protein-impermeable, hydrophilic matrix. By increasing the channel cross-section on the surface of the sensor and/or by connecting the channel/channels to a protein-impermeable, porous, hydrophilic layer on the surface of the sensor, the effect of outer deposits on the diffusion resistance of the analyte is reduced.Type: GrantFiled: February 15, 2008Date of Patent: September 13, 2011Assignee: Roche Diagnostics International AGInventors: Peter Abel, Rudolf Ehwald, Uwe Beyer
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Patent number: 7998922Abstract: A biocompatible polymer constituted by a sequence of identical or different components of the general formula (I): AaXxYy, in which A represents a monomer, X represents a carboxyl group fixed on a monomer A, Y represents a sulfate or sulfonate group fixed on a monomer A; a represents the number of monomers A, x represents the substitution rate of the set of monomers A by the groups X, y represents the substitution rate of the set of monomers A by the groups Y. The invention also pertains to the pharmaceutical or diagnostic compositions containing at least one polymer of general formula (I).Type: GrantFiled: October 28, 2003Date of Patent: August 16, 2011Inventors: Denis Barritault, Jean-Pierre Caruelle
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Patent number: 7989157Abstract: A method for processing biological tissue used in biological prostheses includes providing a tissue procurement solution formed from a phosphate buffered saline (PBS) solution and a chelating agent. The tissue is transferred from the tissue procurement solution and undergoes chemical fixation. The fixed tissue is then immersed in a series of fresh bioburden reduction process (BRP) solutions to extract phospholipids. The tissue procurement solution reduces the bioburden on the stored tissue and preserves tissue architecture by minimizing tissue swelling. The tissue procurement solution further reduces calcium from the incoming water and/or tissue, and inhibits enzymes that digest the collagen matrix. The serial immersion of the tissue in the fresh bioburden solutions ensures optimal extraction of phospholipids thereby mitigating subsequent calcification of the tissue.Type: GrantFiled: January 11, 2005Date of Patent: August 2, 2011Assignee: Medtronic, Inc.Inventors: Crystal M. Cunanan, Alexandro Ochoa, Ronald E. Cambron
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Patent number: 7960166Abstract: The present invention relates to a three-dimensional system, and compositions obtained therefrom, wherein individual layers of the system comprise channels divided longitudinally into two compartments by a centrally positioned membrane, and wherein each compartment can comprise a different cell type.Type: GrantFiled: May 21, 2004Date of Patent: June 14, 2011Assignees: The General Hospital Corporation, The Charles Stark Draper LaboratoryInventors: Joseph P. Vacanti, Jeffrey T. Borenstein, Eli Weinberg
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Patent number: 7959682Abstract: In order to provide a bone substitution material which enables mechanical stability and long-term in-vivo biocompatibility which can also be used for guided bone healing, the invention provides a method comprising the steps of providing a starting material comprising a mixture of at least a skeleton substance (20) and at least one functional substance, and building up a skeleton from the skeleton substance, thereby producing a profiled body (30), as well as a profiled body (30) containing a skeleton substance (20) and comprising a porous structure (10) with pores (12, 15) being interconnected with each other.Type: GrantFiled: September 30, 2004Date of Patent: June 14, 2011Assignee: ADC Advanced Dental Care GmbH & Co. KGInventors: Matthias Epple, Drazen Tadic
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Patent number: 7955831Abstract: The present invention relates to a lactase solution comprising a lactase solution comprising less than 10 g/kg of poly and oligosaccharides, a process for the production of such a lactase solution from an untreated lactase solution, a sterilized lactase solution and to a process for the production of milk containing sterilized lactase, whereby such lactose is filter sterilized in-line with the milk production process.Type: GrantFiled: April 3, 2002Date of Patent: June 7, 2011Assignee: DSM IP Assets B.V.Inventors: Rudolf Franciscus Wilhelmus Cornelis Van Beckhoven, Petrus Andreas Van Paridon
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Patent number: 7947499Abstract: The present invention is of a method of dynamically generating human embryoid bodies which can be used for generating lineage specific cells and cell lines. Specifically, the present invention can be used to generate ESC-differentiated cells for cell-replacement therapy.Type: GrantFiled: November 30, 2003Date of Patent: May 24, 2011Assignee: Technion Research & Development Foundation Ltd.Inventors: Sharon Gerecht-Nir, Joseph Itskovitz-Eldor
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Patent number: 7943353Abstract: A multi-layered microcapsule has an inner extracellular matrix and an outer shell. The inner extracellular matrix includes a first inner layer of biopolymer and a second intermediate layer of polymer that provides partial immune-protection and holds the first layer in place. The outer shell can form an exoskeleton to provide mechanical stability. Each of the individual layers can be varied to optimize mechanical stability, cell function, and immuno-protection.Type: GrantFiled: July 23, 2009Date of Patent: May 17, 2011Assignees: Agency for Science, Technology and Research, The National University of SingaporeInventors: Hanry Yu, Kam W Leong, Ser-Mien Chia, Andrew C. A. Wan
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Patent number: 7943352Abstract: Method and device for the creation of vaccines using ultrasonic waves, comprised of an ultrasound generator and a transducer to produce ultrasonic waves, is disclosed. The transducer has a specific ultrasound tip depending upon the type of delivery method utilized and depending on the shape of the vial containing the solution of the virus, bacterium, or other infectious agent. The apparatus delivers ultrasonic waves to solution either directly through the insertion of the ultrasound tip into the solution, through a coupling medium adjacent to the vial or near the vial, or through an air or gas medium. The ultrasound waves have the effect of destroying the viable virus, bacterium, or other infectious agent and of releasing the appropriate antigens, thus resulting in a vaccine for that virus, bacterium, or other infectious agent.Type: GrantFiled: March 29, 2006Date of Patent: May 17, 2011Assignee: Bacoustics, LLCInventor: Eilaz P. Babaev
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Patent number: 7939066Abstract: A method for the prevention and treatment of fungal infections and, therefore, consequent invasive mycosis in mammalian and avian species is described. The invention comprises a combination of ?-1,3(4)-endoglucanohydrolase, ?-1,3(4)glucan, diatomaceous earth, mineral clay, and glucomannan, which is fed to or consumed by mammalian or avian species in amounts sufficient to inhibit enteric fungal colonization in the gut and consequent mycosis. The invention described may be admixed with feeds or foods, incorporated into pelleted feeds or foods or administered orally to mammalian and avian species.Type: GrantFiled: July 13, 2006Date of Patent: May 10, 2011Assignee: OmniGen Research, LLCInventors: Steven Bruce Puntenney, Neil Elliott Forsberg
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Patent number: 7931938Abstract: This present invention describes a method of coating a polymer surface with diamond-like carbon (DLC) to render it useful as a carrier for cells derived from neural crest origin, preferable neuronal cells that form dendrites. The biopolymer to be coated with the DLC will include biodegradable polymers and other implantable biopolymers to act as a carrier system for cell transplantation into the various parts of the body, including the brain, the eye, the central and peripheral nervous system, the lung, the liver, the spleen, the kidney, and the bone and cartilage. The biopolymer can be in sheet form or microparticle form, and can be imbedded with, or incorporated into during its synthesis, attachment or growth promoting reagents to enhance and support neuraonal call attachment and growth. This coating method can also augment other coating agents such as extracellular matrix (ECM) secreted by cultured bovine corneal endothelial cells, as well as adhesive molecules such as fibronectin, laminin, and RGDS.Type: GrantFiled: October 8, 2004Date of Patent: April 26, 2011Assignee: Cellular Bioengineering, Inc.Inventor: Ge Ming Lui