Abstract: The present invention is directed to a method of replacing collagen broken down during physical activity using a novel dietary supplement. The supplement composition of the present invention comprises collagen, glutamine, taurine, and, optionally, the nine essential amino acids. The uptake of collagen is enhanced using this combination of components to levels substantially near the pre-workout levels.

Abstract: The present invention relates to a novel pharmaceutical use of bromide, i.e. the treatment of autism spectral disorder (ASD).

Abstract: The present invention relates to a process for the production of a homogenous mixture of two or more branched chain keto acids wherein in a first step, two or more free keto acids are mixed, and in a second step, the mixed keto acids are co-crystallized with one or more alkaline earth metal salts, and foodstuff, food supplement or pharmaceutical products containing a mixture of branched-chain keto acids for supporting muscle structure, increasing muscle performance and improving general wellbeing with simultaneous relief of nitrogen detoxification metabolism by reduced nitrogen supply compared to the intake of the corresponding amino acids and an improved nitrogen metabolism in the body.

Abstract: A stabilized active oxygen-generating antiseptic composition is disclosed including at least one of an antiseptic mixture or an antiseptic polymer. The antiseptic mixture includes a persulfate distributed in a matrix of a sulfate wherein the antiseptic composition is characterized by a ratio of the sulfate to the persulfate of at least 8:2. The antiseptic polymer is formed by the reaction of a sulfate, a persulfate, and amino acid in a reaction solution having a ratio of the sulfate to the persulfate of at least 6:4 and a ratio of the amino acid to the sulfate and the persulfate combined of 1:2 to 2:1. An antiseptic irrigation solution is disclosed including the antiseptic composition dispersed in a solvent. An antiseptic article is disclosed including an article and at least one of the antiseptic composition or an antiseptic coating formed from the antiseptic composition disposed on a surface of the article.

Abstract: According to various embodiments of this disclosure, pharmaceutical formulations comprising solubilized estradiol are provided. In various embodiments, such formulations are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.

Abstract: Disclosed herein are lipid emulsified systems containing antihistamines. Also disclosed herein are pharmaceutical compositions containing the lipid emulsified systems and other chemotherapeutic agents, and methods of chemoprevention and cancer treatment with compositions containing the lipid emulsified systems.

Abstract: The present invention relates to a hair cosmetic composition, especially for washing and/or conditioning hair, comprising surfactants and an oil-in-water emulsion that comprises: a silicone mixture comprising a trialkylsilyl terminated dialkylpolysiloxane and an amino silicone; a mixture of emulsifiers comprising one or more nonionic emulsifier, wherein the mixture of emulsifiers has a HLB value from 10 to 16; and water. The invention also relates to a process for the cosmetic treatment of hair, preferably for washing and/or conditioning hair, using this composition.

Abstract: Provided are stem cell biomimetic microparticles comprised of at least one stem cell-derived paracrine polypeptide or growth factor embedded in a polymer core particle that further comprises an outer layer of at least one fragment of a cell membrane of a stem cell disposed on the core particle. The polymer core may be constituted of any biocompatible and biodegradable polymer or copolymer, or a combination thereof that allows the embedding of the paracrine factors and their prolonged release from the core. The core and hence the microparticles can be biodegradable, allowing eventual elimination from the recipient animal or human subject. The core particles are sized to allow both transport through blood vessels and extravasation from the blood vessels into the surrounding tissues. The core particle may further include at least one polypeptide or peptide growth factor to induce the generation and proliferation of a population of stem cells.

Abstract: Multilayer beads for pharmaceutical use having a drug-in-polymer layer are disclosed. The disclosed multilayer beads for pharmaceutical use have (a) a core particle; (b) an optional barrier layer coated on the surface of the core particle; (c) a drug-in-polymer layer coated on the surface of the core or the barrier layer, (d) an optional sealant layer coated on the surface of the drug-in-polymer layer; and (e) optionally one or more outer layers external to the drug-in-polymer layer or the sealant layer. The drug-in-polymer layer consists essentially of (i) a drug selected from the group consisting of a 15-keto prostaglandin drug, a 13,14-dihydro prostaglandin drug, and a 13,14-dihydro-15-keto prostaglandin drug; and (ii) a polymer selected from the group consisting of polyvinylpyrrolidone, vinylpyrrolidone-vinylacetate copolymer or a mixture thereof. The drug-in-polymer layer may be solid dispersion of the drug in the polymer.

Abstract: The present invention relates to a composition comprising probiotics, preferably based on bacteria, in particular of the genus Lactobacillus, to be used for the purpose of preventing and/or treating the disorders affecting the skin, in particular inflammatory disorders, in particular autoinflammatory disorders of dermatological interest such as atopic dermatitis. Furthermore, the composition of the invention is useful for preventing and/or reducing the damage induced by UV radiation, in particular skin aging.

Abstract: The presently-disclosed subject matter relates to compositions of dual layer encapsulated cells, dual layer encapsulated stem cells. The presently-disclosed subject matter further relates to methods for improving retention of cells in vivo at a site of injury.

Abstract: The present embodiments provide compositions, methods and kits for the treatment of ocular conditions or maladies affecting the back of the eye, e.g., the retina.

Abstract: The present invention provides a simple method for producing a medical/cosmetic sheet that is excellent in adhesion to skin or the like and sense of wearing, and is capable of releasing a functional component gradually and supplying it continuously to a treatment area or the like, and a medical/cosmetic sheet produced by this production method. Provided is a method for producing a medical/cosmetic material including a step of shaping a raw material containing a water-soluble salt of a first polyanionic polysaccharide having a viscosity-average molecular weight of 10,000 or lower, and a water-soluble salt of a second polyanionic polysaccharide having a viscosity-average molecular weight of 50,000 or higher, and thereby obtaining a water-soluble shaped body. A medical/cosmetic material produced by this production method is also provided.

Abstract: The present invention relates to frigostable compositions suitable for iontophoretic transdermal delivery of a triptan compound that includes: a salt of a triptan compound, preferably sumatriptan succinate, a polyamine, one or more dicarboxylic acids, 0.5 to 10.0 wt.-% (based on the total weight of the composition) of one or more monocarboxylic acids, and water or an aqueous solvent mixture. The invention further relates to the use of the composition as an integral component of an iontophoretic patch, preferably as an anodic reservoir of the patch.

Abstract: The present invention relates to a process for preparation of a water-insoluble steroid composition by moist heat sterilization. The invention particularly relates to a process for preparation of a water-insoluble steroid composition comprising moist heat sterilization or autoclaving of an aqueous slurry of methylprednisolone acetate in the presence of a specified quantity of polysorbate. The suspensions prepared by using the current invention exhibited good physical and chemical stability. Compositions related thereto are also disclosed.

Abstract: The invention relates to an isotonic crystalloid aqueous solution of the type containing Na+, K+ and Cl?, and to the use thereof as a vasodilator.

Abstract: The invention relates to a personal care composition, more particularly to a composition for application to a topical surface that prevents or reduces inflammation. The composition could be delivered in the form of a skin, scalp, hair or oral care product, more particularly a skin care product. The benefit is delivered via a combination of a polyunsaturated fatty acid (PUFA) or ester thereof selected from docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), DHA-ethyl ester, EPA-ethyl ester, DHA-triglyceride, EPA-triglyceride, dihomogamma-Linolenic Acid (DGLA), DGLA-ethyl ester, DGLA-triglyceride or combinations thereof and a 4-substituted resorcinol compound, wherein the mole ratio of the PUFA or ester thereof to the 4-substituted resorcinol compound is 5:1 to 1:5.

Abstract: The invention relates to a nasally administrable composition comprising at least one active substance in magnesium-containing vesicular carrier, said carrier comprising glycol, phospholipids, water and at least one magnesium source. Methods for nasal administration of the composition, for example, for pain relief, are also provided.

Abstract: Disclosed herein are compositions comprising a membranolytic polymer or a salt thereof and a chemotherapeutic agent or a salt thereof and compositions comprising a membranolytic polymer or a salt thereof and a shielding polymer or a salt thereof. Also disclosed are methods and uses for treating diseases such as cancer with these compositions.

Abstract: Disclosed in the present specification is a skin whitening composition comprising a Bacillus hwajinpoensis strain, a lysate thereof, a cultured product thereof or an extract of the strain, lysate or cultured product as an active ingredient. Disclosed in the present specification is a Bacillus hwajinpoensis strain SNC 135, having an accession number of KCCM12051P, which has a skin whitening function.