Abstract: Compliance voltage generation circuitry for a medical device is disclosed. The circuitry in one embodiment comprises a boost converter and a charge pump, either of which is capable of generating an appropriate compliance voltage from the voltage of the battery in the device. A boost signal from compliance voltage monitor-and-adjust logic circuitry is processed with a telemetry enable signal to selectively enable either the charge pump or the boost converter: if the telemetry enable signal is not active, the boost converter is used to generate the compliance voltage; if the telemetry enable signal is active, the charge pump is used. Because the charge pump circuitry does not produce a magnetic field, the charge pump will not interfere with magnetically-coupled telemetry between the implant and an external controller. By contrast, the boost converter is allowed to operate during periods of no telemetry, when magnetic interference is not a concern.

Abstract: An implantable neurostimulator-implemented method for enhancing post-exercise recovery through vagus nerve stimulation is provided. An implantable neurostimulator, including a pulse generator configured to deliver electrical therapeutic stimulation in a manner that results in creation and propagation (in both afferent and efferent directions) of action potentials within neuronal fibers including a patient's cervical vagus nerve. An operating mode is stored in the pulse generator. An enhanced dose of the electrical therapeutic stimulation is parametrically defined and tuned to prevent or disrupt tachyarrhythmia through continuously-cycling, intermittent and periodic electrical pulses. The patient's physiological state is monitored during physical exercise via at least one sensor included in the implantable neurostimulator, and upon sensing a condition indicative of cessation of the physical exercise, the enhanced dose is delivered for a period of time the enhanced dose to the vagus nerve.

Abstract: A system and method relate to receiving, by a processing device, at least one stream of data captured by at least one sensor monitoring a human subject, wherein the at least one stream of data comprises sensor measurements, comparing the sensor measurements to at least one model of a mental state to estimate the mental state of the human subject, determining whether to trigger an alarm based on the estimated mental state, and in response to determining to trigger the alarm, generating an instruction to trigger the alarm.

Abstract: A medical device for providing an electrical stimulation therapy for a patient includes a microcontroller configured to generate a plurality of electrical pulses and a control signal. The medical device includes a stimulation driver coupled to the microcontroller. The stimulation driver is configured to amplify the electrical pulses into amplified electrical pulses to be delivered to the patient as a part of the electrical stimulation therapy. The medical device includes a battery configured to supply a first voltage. The medical device includes a voltage up-converter coupled between the battery and the stimulation driver. The voltage up-converter is configured to convert, in response to the control signal from the microcontroller, the first voltage to a compliance voltage for the stimulation driver. The compliance voltage is a fraction of the first voltage, and the fraction is greater than 1.

Abstract: A renal denervation feedback method is described that performs a baseline measurement of renal nerve plexus electrical activity at a renal vessel; denervates at least some tissue proximate the renal vessel after performing the baseline measurement; performs a post-denervation measurement of renal nerve plexus electrical activity at the renal vessel, after the denervating; and assesses denervation of the renal vessel based on a comparison of the baseline measurement and the post-denervation measurement of renal nerve plexus electrical activity at the renal vessel.

Abstract: Systems and methods for restoring cognitive function are disclosed. In some implementations, a method includes, at a computing device, separately stimulating one or more of lateral and medial entorhinal afferents and other structures connecting to a hippocampus of an animal subject in accordance with a plurality of predefined stimulation patterns, thereby attempting to restore object-specific memories and location-specific memories; collecting a plurality of one or more of macro- and micro-recordings of the stimulation of hippocampalentorhinal cortical (HEC) system; and refining the computational model for restoring individual memories in accordance with a portion of the plurality of one or more of macro- and micro-recordings.

Abstract: Electrode lead wire connectors configured to be connected to an electrode for defibrillation and/or heart monitoring are disclosed. The electrode lead wire connector includes a one-piece electrically conductive connector contact having one end that is configured to be connected to a lead wire and an opposite end having an electrode receiving section that is configured to releasably receive a post of an electrode. The electrode receiving section includes a detent for retaining the post of the electrode within the electrode receiving section. Resilient engagement between the detent and the post provides a user of the electrode lead wire connector with tactile feedback indicating that the post of the electrode is fully engaged with the electrode receiving section of the one-piece electrically conductive connector contact.

Abstract: Methods for automatically determining whether a patient monitor alarm will sound from a true or false signal, in particular from ventricular tachycardia (VT) and suppressing false alarms without eliminating any true alarms are presented. A multiresolution wavelet is extracted from a raw ECG waveform. Features are then extracted from the wavelets that account for summary statistics, noise, areas under the curve and summary statistics of the KL-divergence of the power spectra density between every two ECG leads. A classifier can be then be trained and its performance measured.

Abstract: An electrical stimulation device is provided. The electrical stimulation device according to one embodiment of the present inventive concept is worn on the head so as to apply electrical stimulation to the brain, and comprises: a frame to be worn on the head; an electrode structure including an electrode part formed of a conductive member and a cover unit formed of an insulating member covering at least a part of the electrode part, and of which one end is connected to the frame; and a patch detachable from the electrode structure and making contact with the head when attached to the electrode structure.

Abstract: The present disclosure discloses an arrangement for measuring a biosignal. The arrangement has a sensor module and a control module. The sensor module has structure for sensing at least one biosignal and a first connector for interfacing with the control module. The control module has a first counterpart connector connected to the first connector of the sensor module, structure for processing biosignal data sensed with the sensor module, a storage memory for storing processed bio signal data, a rechargeable battery for providing operating power for the control module, structure for wirelessly transmitting the processed biosignal data to a computing device, such as a PC, a tablet PC or a smart phone, for post-processing, and a second connector for interfacing with a second electrode.

Abstract: A delivery tool is provided for use in implanting a paddle lead including a paddle electrode array disposed at a distal end of a paddle lead body. The delivery tool has a proximal tool end and a distal tool end opposite the proximal end and a tool body extending therebetween. The tool body is adapted to receive a portion of the paddle lead body and includes a longitudinal member extending along the tool body and a plurality of structural members extending from the longitudinal member. The structural members are distributed along the longitudinal member such that gaps are defined between longitudinally adjacent structural members. The tool body is structured to have increased resistance to bending in a first direction and reduced resistance to bending in a second direction perpendicular to the first direction.

Abstract: It is an object of the present invention to provide a heart rate monitor system (10) which is able to determine the resting heart rate in an effective and unobtrusive manner. In an aspect of the present invention, a heart rate monitor system (10) comprising an inactivity determining unit (320) for determining periods of inactivity (IP) of a user based on motion data (MD) detected by at least one motion sensor (200) attached to the user and a resting heart rate calculating unit (330) for calculating a resting heart rate (RHR) of the user based on heart rate data (HR) detected by at least one heart rate sensor (100) attached to the user during the periods of inactivity (IP) as determined by the inactivity determining unit (320) is provided.

Abstract: In a patient suffering from neural impairment, stimulation is provided to sensory surfaces of the face and/or neck, or more generally to areas of the body that stimulate the trigeminal nerve, while performing an activity intended to stimulate a brain function to be rehabilitated. The simulation may then be continued after the performance of the activity has ceased. It has been found that the patient's performance of the activity is then improved after stimulation has ceased. Moreover, it tends to improve to a greater extent, and/or for a longer time, when the post-activity stimulation is applied, as compared to when post activity stimulation is not applied.

Abstract: Systems and methods are provided for applying electrical stimulation to a body by an electrode spaced from a target nerve of passage. It has been discovered that pain felt, or perceived to be felt, in a given region of the body can be treated by stimulating muscle close to a “nerve of passage” in a region that is superior (i.e., cranial or upstream toward the spinal column) to the region where pain is felt, such as in a case of post-amputation residual limb pain, or purportedly felt in the case of post-amputation phantom limb pain.

Abstract: Techniques for using multiple physiological parameters to provide an early warning for worsening heart failure are described. A medical device monitors a primary diagnostic parameter that is indicative of worsening heart failure, such as intrathoracic impedance or pressure, and one or more secondary diagnostic parameters. The medical device detects worsening heart failure in the patient based on the primary diagnostic parameter when an index that is changed over time based on the primary diagnostic parameter value is outside a range of values, termed the threshold zone. When the index is within the threshold zone, the medical device detects worsening heart failure in the patient based on the one or more secondary diagnostic parameters. Upon detecting worsening heart failure, the medical device may, for example, provide an alert that enables the patient to seek medical attention before experiencing a heart failure event.

Abstract: This document describes an automated external defibrillator comprising a control configured to switch between a pediatric operating mode and an adult operating mode, wherein each operating mode comprises a mode-specific energy configuration and a mode-specific user configuration; an indicator configured to provide an indication of the operating mode in use during a resuscitation process; one or more processors configured to switch to the mode-specific energy configuration and the mode-specific user configuration upon a change of operating mode between the pediatric operating mode and the adult operating mode such that the automated external defibrillator delivers a defibrillating shock to a patient based on the mode-specific energy configuration; and an interface of the automated external defibrillator provides resuscitation instructions to a user based on the mode-specific user configuration.

Abstract: A method to provide non-invasive neurostimulation to enhance a subject's proficiency in an exercise includes: (a) engaging a subject in a physical or mental exercise, the subject having no cognitive, physical or emotional impairment; (b) providing intraoral cutaneous stimulation of at least one of the subject's trigeminal nerve, facial nerve or hypoglossal nerve by delivering electrical pulses to one or more stimulators situated within the subject's mouth, the delivery of electrical pulses being (i) contemporaneously with and independent of the subject's engagement in the exercise, and (ii) independent of the subject's surrounding environment; and (c) repeating steps (a) and (b) on a periodic basis.

Abstract: An electrode connector assembly for the use in transcutaneous electrical stimulation includes a flexible web extending in a plane and first, second, third and fourth electrode connectors carried by the web and spaced from each other about the web in the plane. The electrode connector assembly further includes an electrical connector and first, second, third and fourth conductors electrically coupling the respective first, second, third and fourth electrode connectors to the electrical connector.

Abstract: Described herein are methods and devices for selectively applying either fluids (e.g., anesthetics, nerve-blockers, etc.) or energy, such as radiofrequency or ultrasound energy, to a target tissue from within a blood vessel while minimizing the amount of fluid or energy applied to non-target tissue. The catheters described herein may include an elongate body, a directional injector, and one or more holdfasts for securing the catheter. In addition, catheters can include energy applying features for delivering energy to the target tissue.

Abstract: A method for operating a bioelectric differential measurement arrangement includes detecting a bioelectric measurement signal. The bioelectric measurement signal includes a bioelectric useful signal and an interference signal. The method also includes detecting the interference signal by a common-mode current measurement by the bioelectric differential measurement arrangement.