Patents Examined by Amanda L Aguirre
  • Oxazetidine derivatives, process for preparing them and use in human medicine and in cosmetics
    Patent number: 9353083
    Abstract: Methods for treating hypopigmentary pathologies and photosensitive dermatoses are described. Also described, are compounds that are agonists of the MCIR receptor and that exhibit reduced toxicity relative to other compounds of the same class. These compounds can have the general formula (I) wherein: R1 represents a cyclopropylmethyl or a 4-hydroxybutyl group; R2 represents a hydrogen atom or a methyl group; and also the salts and enantiomers of the corresponding compounds of general formula (I).
    Type: Grant
    Filed: June 28, 2012
    Date of Patent: May 31, 2016
    Assignee: GALDERMA RESEARCH & DEVELOPMENT
    Inventor: Claire Bouix-Peter
  • Method for stopping ammoxidation reaction
    Patent number: 9346747
    Abstract: An object of the present invention is to provide a method for, when stopping an ammoxidation reaction of propane, stopping the ammoxidation reaction safely and quickly, without causing a deterioration in catalytic activity or acrylonitrile yield. The method for stopping an ammoxidation reaction includes a supply stopping step of stopping a supply of propane, an oxygen-containing gas, and ammonia to a reactor where an ammoxidation reaction of propane is being carried out using a catalyst, and a reaction stopping step of supplying an inert gas to the reactor in an amount 10 to 300 times the catalyst volume per hour until the catalyst temperature reaches 380° C. or less, wherein after the supply stopping step, a time required until the catalyst temperature decreases to 360° C. or less is within 10 hours.
    Type: Grant
    Filed: September 13, 2013
    Date of Patent: May 24, 2016
    Assignee: ASAHI KASEI CHEMICALS CORPORATION
    Inventors: Sho Tamura, Sadao Shoji
  • Antiprotozoal compounds
    Patent number: 9346777
    Abstract: The invention is directed to a compound of formula I, as defined herein, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition containing a compound of formula I, a method of treatment of a disorder or condition that may be treated by administration of the compound, the method comprising administering to a mammal in need of such treatment a compound of formula I as described above, and a method of treatment of a disorder or condition selected from the group consisting of Human African Trypanosomiasis (HAT), Chagas disease, Leishmaniasis and malaria, the method comprising administering to a mammal, including a human, in need of such treatment a compound of formula I as described above.
    Type: Grant
    Filed: August 4, 2013
    Date of Patent: May 24, 2016
    Assignee: MediSynergics, LLC
    Inventors: Dennis Michael Godek, Harry Ralph Howard
  • Anti-cancer cycloalkyl diamines
    Patent number: 9345673
    Abstract: The invention is directed to a method of treatment of a cancer, in a mammal, the method comprising administering to said mammal in need of such treatment an effective amount of a cell growth inhibitory compound of formula I or a pharmaceutically acceptable salt form thereof.
    Type: Grant
    Filed: July 14, 2015
    Date of Patent: May 24, 2016
    Assignee: MediSynergics, LLC
    Inventors: Dennis Michael Godek, Harry Ralph Howard
  • Process to prepare a chelating agent or precursor thereof using a cyanide salt
    Patent number: 9334232
    Abstract: The present invention relates to a process comprising the reaction of a cyanide with an amino acid and an aldehyde, characterized in that the cyanide is a cyanide salt, the amino acid is aspartic acid and/or glutamic acid in the acidic form, and the process is performed under acidic pH by the addition of between 0 and 1 equivalent of an acid based on the amount of aspartic or glutamic acid.
    Type: Grant
    Filed: June 3, 2010
    Date of Patent: May 10, 2016
    Assignee: AKZO NOBEL CHEMICALS INTERNATIONAL B.V.
    Inventors: Hans Lammers, Martin Heus, Tjerk Oedse Boonstra, Adrianus Maria Reichwein
  • Process for preparation of dicyanocarboxylate derivatives
    Patent number: 9309190
    Abstract: The present disclosure provides a process for preparing 2,3-dicyanopropionic acid ester of formula (I); said process comprising the following steps: i) treating an alkali metal cyanide dissolved in a solvent with a solution of 2-cyano-2-propenoic acid ester of formula (II) at a temperature ranging between 0° C. and 50° C. for a time period ranging between 2 hours and 15 hours followed by cooling below 20° C. to obtain a sodium salt of 2,3-dicyanopropionic acid ester of formula (I); and ii) neutralizing the sodium salt of 2,3-dicyanopropionic acid ester using a neutralizing agent to obtain a 2,3-dicyanopropionic acid ester of formula (I).
    Type: Grant
    Filed: October 24, 2013
    Date of Patent: April 12, 2016
    Inventor: Keki Hormusji Gharda
  • Method for producing nitrile compounds from ethylenically unsaturated compounds
    Patent number: 9309189
    Abstract: The present invention relates to a method for the hydrocyanation of organic ethylenically unsaturated compounds including at least one nitrile function. The invention specifically relates to a method for the hydrocyanation of a hydrocarbon compound including at least one ethylenic unsaturation by a reaction with hydrogen cyanide in a liquid medium and in the presence of a catalyst including a metal element selected from the transition metals and an organophosphorous ligand, the organophosphorous ligand including a compound of general formula (I), where R1 and R2, which are identical or different, are a linear or branched alkyl radical having 1-12 carbon atoms, which can include heteroatoms, or an optionally substituted aromatic or cycloaliphatic radical that can include heteroatoms, wherein the covalent bond between P and R1, and that between P and R2, are P—C bonds.
    Type: Grant
    Filed: September 27, 2012
    Date of Patent: April 12, 2016
    Assignee: INVISTA NORTH AMERICA S.A R.L.
    Inventors: Sergio Mastroianni, Paul Pringle, Jonathan Hopewell, Michael Garland
  • Methods for providing bond activation catalysts and related catalysts, systems, and methods
    Patent number: 9308525
    Abstract: Described herein are catalysts for activation of an R—H bond in a R—H substrate and related catalytic matrices, compositions, methods and systems.
    Type: Grant
    Filed: February 27, 2014
    Date of Patent: April 12, 2016
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: William A. Goddard, III, Mu-Jeng Cheng, Ross Fu
  • Benzenesulfonamide derivatives of quinoxaline, pharmaceutical compositions thereof, and their use in methods for treating cancer
    Patent number: 9295671
    Abstract: Chemical entities that are benzenesulfonamide derivatives of quinoxaline, pharmaceutical compositions and methods of treatment of cancer are described.
    Type: Grant
    Filed: August 24, 2012
    Date of Patent: March 29, 2016
    Assignee: NEUPHARMA, INC.
    Inventors: Yong-Liang Zhu, Xiangping Qian
  • Pre calcination additives for mixed metal oxide ammoxidation catalysts
    Patent number: 9295977
    Abstract: A process for preparation of catalysts for the production of acrylonitrile, acetonitrile and hydrogen cyanide comprising contacting at an elevated temperature, propylene, ammonia and oxygen in the vapor phase in the presence of a catalyst, said catalyst comprising a complex of metal oxides wherein a heat-decomposable nitrogen containing compound is added during the process for the preparation of the catalyst.
    Type: Grant
    Filed: August 11, 2014
    Date of Patent: March 29, 2016
    Assignee: INEOS USA LLC
    Inventors: James Frank Brazdil, Charles James Besecker, Michael J. Seely, Muin S. Haddad, Mark A. Toft
  • Process for manufacturing acrolein/acrylic acid
    Patent number: 9296676
    Abstract: The present invention relates to the selective elimination of propanal in acrolein-rich streams to produce acrolein and/or acrylic acid and/or acrylonitrile and/or methylmercaptopropionaldehyde containing low amount of propanal and/or propionic acid and/or propionitrile. One subject of the present invention is a process for manufacturing acrolein comprising a step of selective elimination of propanal in an acrolein-rich stream in contact with a catalyst comprising at least molybdenum. Another subject of the present invention is a process for manufacturing acrylic acid from glycerol including a step of selective elimination of propanal in an acrolein-rich stream in contact with a catalyst comprising at least molybdenum.
    Type: Grant
    Filed: January 26, 2012
    Date of Patent: March 29, 2016
    Assignee: Arkema France
    Inventors: Jean-Francois Devaux, Jean-Luc Dubois
  • Method for producing ester compound by reacting an unsaturated organic compound and a formic acid ester in the presence of a catalyst system containing a ruthenium compound, a cobalt compound and a halide salt
    Patent number: 9295981
    Abstract: Disclosed is an effective method for producing an ester compound at a reaction temperature lower than that of conventional methods, and with a high yield, even when inexpensive formic acid ester is used as a starting material. A method for producing an ester compound, the method comprising the step of reacting an organic compound having at least one unsaturated carbon bond in the molecule, and a formic acid ester in the presence of a catalyst system containing: a ruthenium compound; a cobalt compound; and a halide salt.
    Type: Grant
    Filed: May 13, 2010
    Date of Patent: March 29, 2016
    Assignees: HITACHI CHEMICAL COMPANY, LTD., NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
    Inventors: Hiroyuki Kawakami, Kenichi Tominaga, Kazuhiko Sato
  • Compositions and methods for the treatment of norovirus infection
    Patent number: 9296719
    Abstract: Compositions and methods for the treatment of norovirus infection are disclosed.
    Type: Grant
    Filed: July 9, 2012
    Date of Patent: March 29, 2016
    Assignees: Indiana University Research and Technology Corporation, Alios Biopharma, Inc.
    Inventors: Ch. V. Subba-Reddy, C. Cheng Kao, Dave Smith, Leo Beigelman
  • Process for the preparation of derivatives of 1-(2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid
    Patent number: 9290428
    Abstract: The present invention relates to a process for the preparation of a compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein R represents one or more groups independently selected from fluorine, chlorine, bromine, and iodine, said process comprising the cyclopropanation of a compound of formula (II) with ethylene carbonate or ethylene sulfate: wherein X is chlorine, bromine, iodine or a triflate group (CF3SO3) or a group wherein R is as defined above and G is —CN or —COOR2 wherein R2 is a C1-C4 straight or branched alkyl chain.
    Type: Grant
    Filed: June 23, 2014
    Date of Patent: March 22, 2016
    Assignee: CHIESI FARMACEUTICI S.p.A.
    Inventors: Massimo Verzini, Livius Cotarca, Alberto Guidi, Alfonso Melloni, Paolo Maragni
  • Cycloalkyl-diamines for CNS disorders
    Patent number: 9283196
    Abstract: The invention is directed to the use of a compound of formula I as defined herein, a pharmaceutically acceptable salt thereof; or a pharmaceutical composition containing a compound of formula I, in treating a mammal, including a human, for a psychiatric disorder or condition selected from the group consisting of depression, mood disorders, anxiety, schizophrenia, bipolar disorder (also referred to as manic-depressive disorder), addiction, cognitive impairment, Parkinson's and Alzheimer's diseases.
    Type: Grant
    Filed: July 16, 2015
    Date of Patent: March 15, 2016
    Assignee: MediSynergics, LLC
    Inventors: Dennis Michael Godek, Harry Ralph Howard
  • Substituted 2-imidazolidinones and 2-imidazolones and their use in the treatment of cancer
    Patent number: 9278937
    Abstract: Compounds of formula (I) wherein R1, R4, R8, X and Y as defined herein are provided as useful for the inhibition of certain types of cancer cells, amongst others, breast cancer cells, or for the manufacture of anti-cancer agents.
    Type: Grant
    Filed: August 10, 2012
    Date of Patent: March 8, 2016
    Assignee: UNIVERSITE LAVAL
    Inventors: Rene C.-Gaudreault, Sebastien Fortin
  • Method for preparing high-purity fesoterodine fumarate
    Patent number: 9272982
    Abstract: A process is described for preparing fesoterodine fumarate comprising the salification reaction of fesoterodine with fumaric acid in an organic solvent, preferably a ketone, at a temperature not greater than 45° C. Such process allows obtaining products with high yields and purities, and in particular a product having a content of (2E)-4-[(3-(3-diisopropylamino-1-phenylpropyl)-4-(2-isobutyroyloxyphenyl)methoxy]-4-oxobut-2-enoic acid less than or equal to 0.15% by mole.
    Type: Grant
    Filed: June 19, 2014
    Date of Patent: March 1, 2016
    Assignee: CHEMI S.P.A.
    Inventors: Umberto Ciambecchini, Elio Ullucci, Stefano Turchetta, Maurizio Zenoni
  • Methods for production of L-methionine and related products
    Patent number: 9260732
    Abstract: A method comprising: (a) enzymatically processing an O-acetylhomoserine (OAHS) fermentation liquor to produce L-methionine and an acetate source; (b) separating at least a portion of said L-methionine from at least a fraction of said acetate source to form separated L-methionine and a residual liquor comprising an acetate-source; and (c) recovering at least a portion of said acetate source from said residual liquor as recovered acetate.
    Type: Grant
    Filed: December 29, 2011
    Date of Patent: February 16, 2016
    Assignee: CJ CHEILJEDANG CORP
    Inventors: Soon Won Hong, In Seok Hwang, Sang Mok Lee, Youn Jae Lee, Jun Young Jung, Aharon Eyal
  • Compounds having antibacterial activity, process for their preparation and pharmaceutical compositions comprising them
    Patent number: 9255071
    Abstract: A pharmaceutically acceptable salt, prodrug or derivative compound of the formula I, wherein R1 is selected from H, a (C1-C5) alkyl group and a COR4 group; R2 is selected from H, a (C1-C5) alkyl group and a COR5 group; R3 is selected from H, a (C1-C5) alkyl group, a (C1-C5)-O-alkyl group, a cycloalkyl of (C5-C6) carbon atoms, an aryl group, and an aryl (C1-C5) alkyl group wherein the aryl group can be an unsubstituted aryl or substituted with one or more R6 groups and an NHCOR5 group, or the R2 and R3 groups together with N may form a piperidine, morpholine or piperazine group; R4 is selected from H and a (C1-C5)alkyl group; R5 is selected from an aryl group unsubstituted or substituted with one or more R6, linear or branched(C1-C5) alkyl or pyridyne groups and a pyridine group; R6 is selected from (C1-C5)alkyl groups, halogen and nitro.
    Type: Grant
    Filed: January 10, 2013
    Date of Patent: February 9, 2016
    Assignees: Consejo Nacional de Investigaciones Cientificas y Técnicas (CONICET), Laboratorios Richmond Sociedad Anónima Comercial Industrial y Financiera
    Inventors: Gerardo Burton, Fernando Javier Duran, Mario David Martinez, Elvira Zini, Veronica Mora Munoz, Lucila Bertoncello
  • Dicarboximide derivatives of berbamine, the preparation and use thereof
    Patent number: 9249137
    Abstract: The present invention relates to a novel dicarboximide derivative of berbamine represented by formula I, including, but not limited to, a phthalimide derivative of berbamine and an aromatic heterocyclic dicarboximide derivative of berbamine, or a pharmaceutically acceptable salt thereof, to a process for preparation of the same, to a pharmaceutical composition comprising said compound and to use thereof in manufacture of an antitumor medicament.
    Type: Grant
    Filed: August 25, 2011
    Date of Patent: February 2, 2016
    Assignee: HANGZHOU BENSHENG PHARMACEUTICAL CO., LTD.
    Inventors: Rongzhen Xu, Frank Rong, Fuwen Xie, Hongxi Lai