Patents Examined by Amelia A. Owens
  • Substituted benzopyran derivatives against arrhythmia
    Patent number: 7041700
    Abstract: This invention relates to benzopyran derivatives of the formula (1) or the formula (2) wherein R1 and R2 represent independently of each other hydrogen atom or C1-6alkyl group, R3 represents hydroxyl group or C1-6 alkylcarbonyloxy group, R4 represents hydrogen atom or C1-6 alkyl group, R5 represents C1-6 alkyl group substituted with C6-14 aryl group or heteroaryl group, R6 represents C1-6 alkyl group, C1-6 alkoxy group, halogen atom, nitro group, C(O)NH2, C(O)NHR8 or C(O)NR8R9, or pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: June 17, 2002
    Date of Patent: May 9, 2006
    Assignee: Nissan Chemical Industries, Ltd.
    Inventors: Yoshio Ohara, Kazuhiko Ohrai, Kazufumi Yanagihara, Yukihiro Shigeta, Toru Tsukagoshi, Toru Yamashita
  • Process for oxidizing carbon-carbon double bond and process for producing oxidized compounds
    Patent number: 7038069
    Abstract: A method of oxidizing a carbon-carbon double bond wherein the compound having the carbon-carbon double bond is suppressed, the unreacted compound is separated from the reaction product, and thereafter the thus obtained unreacted compound is again used for the oxidizing reaction; and a process for producing an oxidized compound utilizing such an oxidizing method. When this method is used, an intended oxidized compound can be obtained with high selectivity and high productivity.
    Type: Grant
    Filed: December 24, 2002
    Date of Patent: May 2, 2006
    Assignee: Showa Denko K.K.
    Inventors: Wataru Oguchi, Makoto Nishi, Yukiharu Hetsugi
  • Protected 3,-5-dihydroxy-2,2-dimethyl-valeronitriles for the synthesis of epothilones and epothilone derivatives and process for the production
    Patent number: 7034165
    Abstract: The invention relates to 3,5-dihydroxy-2,2-dimethyl-valeronitriles for the synthesis of epothilones and epothilone derivatives and process for the production of these new intermediate products in the synthesis and the use for the production of epothilones or epothilone derivatives.
    Type: Grant
    Filed: August 5, 2002
    Date of Patent: April 25, 2006
    Assignee: Schering AG
    Inventors: Jurgen Westermann, Johannes Platzek, Orlin Petrov
  • Compounds
    Patent number: 7030139
    Abstract: Compounds of general formula (I), are disclosed and claimed in the present application, as well as salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain
    Type: Grant
    Filed: April 18, 2002
    Date of Patent: April 18, 2006
    Assignee: AstraZeneca AB
    Inventors: Yun-Xing Cheng, Miroslaw Tomaszewski, Christopher Walpole, Hua Yang
  • Stability of lipoic acid
    Patent number: 7030154
    Abstract: A method of stabilizing R-?-lipoic acid includes combining R-?-lipoic acid with nicotinamide in a weight ratio between about 10:4 to about 10:8. A composition for treating oxidative stress includes R-?-lipoic acid and nicotinamide in a weight ratio of between about 10:4 and about 10:8.
    Type: Grant
    Filed: June 5, 2003
    Date of Patent: April 18, 2006
    Assignee: Juvenon, Inc.
    Inventor: Bruce N. Ames
  • Substituted heterocyclic compounds
    Patent number: 7026321
    Abstract: Disclosed are novel heterocyclic derivatives, useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction. The compounds are also useful in the treatment of diabetes.
    Type: Grant
    Filed: January 16, 2004
    Date of Patent: April 11, 2006
    Assignee: CV Therapeutics, Inc.
    Inventors: Robert Jiang, Tim Marquart, Jeff Zablocki, Elfatih Elzein, Venkata Palle, Prabha Ibrahim
  • Method for producing an epoxide
    Patent number: 7026493
    Abstract: An organic compound having at least one C—C double bond is epoxidized by means of hydrogen peroxide in the presence of at least one catalytically active compound and at least one solvent, wherein a product mixture comprising ?-hydroperoxyalcohols is reduced using at least one reducing agent.
    Type: Grant
    Filed: February 6, 2002
    Date of Patent: April 11, 2006
    Assignee: BASF Aktiengesellschaft
    Inventors: Joaquim Henrique Teles, Alwin Rehfinger, Anne Berg, Peter Rudolf, Norbert Rieber, Peter Bassler
  • Substituted heterocyclic compounds
    Patent number: 7001909
    Abstract: Disclosed are novel heterocyclic derivatives, useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction. The compounds are also useful in the treatment of diabetes, and for increasing HDL plasma levels in mammals.
    Type: Grant
    Filed: January 17, 2003
    Date of Patent: February 21, 2006
    Assignee: CV Therapeutics, Inc.
    Inventors: Prabha Ibrahim, Kevin Shenk, Elfatih Elzein, Venkata Palle, Jeff Zablocki, Kenneth S. Rehder
  • 5-androsten-3?-ol steroid intermediates and processes for their preparation
    Patent number: 7002028
    Abstract: The present invention provides 5-androsten-3?-ol steroid intermediates and processes for their preparation.
    Type: Grant
    Filed: June 1, 2004
    Date of Patent: February 21, 2006
    Assignee: Warner-Lambert Company
    Inventors: Michael J. White, Peter Guillaume Marie Wuts, Doris Beck
  • Process for the preparation of citalopram
    Patent number: 7002025
    Abstract: Preparation of citalopram comprises the steps of: (a) converting the compound of Formula (I) to a compound of Formula (II), wherein R in Formula (I) represents a C2 to C5 alkylene group which may be substituted or unsubstituted, and R1 in the compounds of Formula (II) represents a carboxylic acid group or a salt or an ester thereof; and (b) converting the compound of Formula (II) to form citalopram or a pharmaceutically acceptable salt thereof, or a direct conversion of the compound of Formula (I) to citalopram
    Type: Grant
    Filed: March 7, 2001
    Date of Patent: February 21, 2006
    Assignee: Resolution Chemicals Limited
    Inventors: Alan K. Greenwood, Derek McHattie, Josef A. Rechka, Paul C. M. Hedger, Mark P. Gamble
  • C7 carbonate taxane compositions
    Patent number: 6992104
    Abstract: Taxanes having a carbonate substituent at C(7), a hydroxy substituent at C(10), and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Grant
    Filed: December 22, 2003
    Date of Patent: January 31, 2006
    Assignee: FSU Research Foundation, Inc.
    Inventor: Robert A. Holton
  • Lactone compound
    Patent number: 6992197
    Abstract: A novel monomer compound having a lactone moiety of the present invention can be converted into polymers usable as resist materials with excellent properties, etc., and an alcohol compound having a lactone moiety of the invention is useful as a material for the monomer compound. The compounds are represented by the following general formula [1]: wherein one of R1 and R2 represents a hydrogen atom, an acryloyl group, or a methacryloyl group, and the other represents an alkyl group; R3 and R4 independently represent a hydrogen atom or an alkyl group; R5 and R6 both represent a hydrogen atom or are combined to form a methylene chain that may have an alkyl group; and R7 and R8 independently represent a hydrogen atom or a methyl group.
    Type: Grant
    Filed: June 10, 2004
    Date of Patent: January 31, 2006
    Assignee: Takasago International Corporation
    Inventors: Junji Nakamura, Shigetaka Numasawa, Hiroyuki Kenmochi, Yoji Hori
  • 5-Nitrobenzofurans
    Patent number: 6984741
    Abstract: The present invention relates to 5-nitrobenzofurans, to a process for preparing 5-nitrobenzofurans, and to 5-nitro-2,3-dihydrobenzofuran-3-ols, to a process for the preparation thereof and to intermediates.
    Type: Grant
    Filed: August 18, 2003
    Date of Patent: January 10, 2006
    Assignee: Bayer Aktiengesellschaft
    Inventor: Wolfgang Mägerlein
  • Oxindole derivatives
    Patent number: 6964977
    Abstract: The present invention is related to oxindole derivatives of structure (I), compositions containing the same, and methods of use and manufacture of the same. Such compounds generally are useful pharmacologically as agents in those disease states alleviated by the alteration of mitogen activated signaling pathways in general, and in particular in the inhibition or antagonism of protein kinases, which pathologically involve aberrant cellular proliferation. Such disease states include tumor growth, restenosis, atherosclerosis, pain and thrombosis. In particular, the present invention relates to a series of substituted oxindole compounds, which exhibit Trk family protein tyrosine kinase inhibition, and which are useful in cancer therapy and chronic pain indications.
    Type: Grant
    Filed: August 23, 2001
    Date of Patent: November 15, 2005
    Assignee: SmithKline Beecham Corporation
    Inventors: Philip Anthony Harris, Robert N Hunter, Robert Walton McNutt, Jr., Lee Frederick Kuyper, Karen Elizabeth Lackey, Michael Robert Peel, Edgar Raymond Wood, III
  • Process for the preparation of 4,10?-diacetoxy-2?-benzoyloxy-5?,20-epoxy-1,13?-dihydroxy-9-oxo-19-norcyclopropa[g]tax-11-ene
    Patent number: 6956124
    Abstract: There is disclosed a process for the preparation of 4-acetoxy-2?-benzoyloxy-5?,20-epoxy-1,13?-dihydroxy-9-oxo-19-norcyclopropa[g] tax-11-ene from 4-acetoxy-2?-benzoyloxy-5?,20-epoxy-1,13?-dihydroxy-9-oxo-7?-(trifluoromethyl sulfonyloxy) tax-11-ene by reaction with a molecular sieve in sulfolane.
    Type: Grant
    Filed: April 14, 2004
    Date of Patent: October 18, 2005
    Assignee: Aventis Pharma S.A.
    Inventors: Eric Didier, Guy Amouret
  • 2H-1-benzopyran derivatives processes for their preparation and pharmaceutical compositions thereof
    Patent number: 6951883
    Abstract: 2H-1-Benzopyran derivatives, processes for their preparation and use thereof for the preparation of pharmaceutical compositions for the prevention and treatment of postmenopausal pathologies.
    Type: Grant
    Filed: January 21, 2002
    Date of Patent: October 4, 2005
    Assignee: Chiesi Farmaceutici S.p.A.
    Inventors: Maurizio Delcanale, Gabriele Amari, Elisabetta Armani, Maurizio Civelli, Elisabetta Galbiati
  • Motilide compounds
    Patent number: 6946482
    Abstract: Motilide compounds having the formula (I), wherein R1, R2, R3, and R4 are as defined herein, and methods for their preparation and use in the treatment of diseases or conditions characterized by impaired gastric motility.
    Type: Grant
    Filed: August 26, 2003
    Date of Patent: September 20, 2005
    Assignee: Kosan Biosciences, Inc.
    Inventors: Daniel V. Santi, Brian Metcalf, Christopher Carreras, Yaoquan Liu, Robert McDaniel, Eduardo J. Rodriguez
  • 5-[phenyl-tetrahydronaphthalene-2-yl dihydronaphthalen-2-yl and heteroaryl-cyclopropyl]-pentadienoic acid derivatives having serum glucose reducing activity
    Patent number: 6936636
    Abstract: Compounds of the formula: where the variables have the meaning defined in the specification are capable of reducing serum glucose levels in diabetic mammals without the undesirable side effects of reducing serum thyroxine levels and transiently increasing triglyceride levels.
    Type: Grant
    Filed: June 26, 2003
    Date of Patent: August 30, 2005
    Assignee: Allergan, Inc.
    Inventors: Santosh Sinha, Kwok Yin Tsang, Smita Bhat, Roshantha A. Chandraratna
  • Synthetic salicylihalamides, apicularens and derivatives thereof
    Patent number: 6936723
    Abstract: The present invention provides compounds having improved stability over that of natural benzolactones, and a process for synthesizing these compounds. These compounds exhibit anti-cancer activity and inhibit V-ATPase activity.
    Type: Grant
    Filed: March 1, 2004
    Date of Patent: August 30, 2005
    Assignee: Board of Regents, The University of Texas System
    Inventors: Jef De Brabander, Yusheng Wu
  • Cannabinoid drugs
    Patent number: 6914072
    Abstract: The invention relates to the use of cannabinoid compounds (derivatives of tetrahydrocannabinol) for decreasing cell proliferation in a mammal.
    Type: Grant
    Filed: May 17, 2001
    Date of Patent: July 5, 2005
    Assignee: Indevus Pharmaceuticals, Inc.
    Inventors: Sumner Burstein, Lawrence Recht, Robert B. Zurier