Patents Examined by Amelia Averill Owens
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Patent number: 6951877Abstract: The subject invention provides novel HMG-CoA-reductase inhibitors. In a preferred embodiment, the HMG-CoA reductase inhibitors of the subject invention can be deactivated to a primary inactive metabolite by hydrolytic enzymes. Compounds of the present invention can be advantageously used to treat patients suffering hypercholesterolemia.Type: GrantFiled: July 21, 2003Date of Patent: October 4, 2005Assignee: ARYx Therapeutics, Inc.Inventors: Pascal Druzgala, Xiaoming Zhang
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Patent number: 6946556Abstract: A one-pot process for preparing opioid analgesics such as hydrocodone, hydromorphone, and analogues thereof by reacting codeine, morphine, and analogues thereof with hydrogen in a solvent system of benzophenone and neutral solvent in the presence of a metal catalyst followed by oxidation in the presence of potassium tert-alkylate.Type: GrantFiled: May 21, 2004Date of Patent: September 20, 2005Assignee: Acura Pharmaceuticals, Inc.Inventors: Igor Likhotvorik, Joseph J. Lisowski
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Patent number: 6930111Abstract: Disclosed are novel heterocyclic derivatives, useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction. The compounds are also useful in the treatment of diabetes, and for increasing HDL plasma levels in mammals.Type: GrantFiled: July 18, 2002Date of Patent: August 16, 2005Assignee: CV Therapeutics, Inc.Inventors: Prabha Ibrahim, Kevin Shenk, Elfatih Elzein, Venkata Palle, Jeff Zablocki, Kenneth S. Rehder
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Patent number: 6881851Abstract: Disclosed is a process for the preparation of tetrahydro-3-furoic acid by the thermal, non-catalytic oxidation of 3-formyltetrahydrofuran using molecular oxygen.Type: GrantFiled: April 21, 2004Date of Patent: April 19, 2005Assignee: Eastman Chemical CompanyInventors: John Robert Monnier, Elaine Beatrice Mackenzie
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Patent number: 5854280Abstract: A compound of formula ##STR1## wherein Z is a tetrahydro-pyrano group selected from ##STR2## having antifungal activity processes for their preparation and their use in medicines.Type: GrantFiled: October 18, 1996Date of Patent: December 29, 1998Assignee: Glaxo Wellcome S.A.Inventors: Jose R. Ruiz Gomez, Jose Maria Bueno Calderon, Silvestre Garcia-Ochoa Dorado, Maria T. Fraile Gabaldon, Julia C. Pichel, Jose M. Fiandor Roman, Domingo Gargallo Viola, Juan C. Cuevas Zurita, Jose L. Lavandera Diaz, Sophie Huss
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Patent number: 5777133Abstract: Compounds having the formula: ##STR1## wherein T is a polycycloalkylidene group (e.g., adamant-2-ylidene); R is a C.sub.1-20 alkyl, aralkyl or cycloalkyl group; and Y is a fluorescent chromophore (eg., m-phenylene), produced by reacting a compound having the formula: ##STR2## with an R-ylating agent (e.g., R.sub.2 SO.sub.4) in the presence of an alkali metal alkoxide in a polar aprotic solvent. Also, compounds having the formula: ##STR3## are produced by reacting a compound having the formula: ##STR4## wherein X is an electronegative leaving group (e.g., a halogen anion such as chloride ion) in the presence of a Lewis base (e.g., a trialkyl-amine) dissolved in an aprotic organic solvent (e.g., benzene or toluene). Also, compounds having the formula ##STR5## are produced by reacting a compound of the formula ##STR6## with a tetra-O-acylated-O-hexopyranoside halide, then hydrolyzing off the protective acyl groups.Type: GrantFiled: January 28, 1997Date of Patent: July 7, 1998
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Patent number: 5767147Abstract: This invention relates to novel haloenol lactone compounds. These compounds have the following general structure: ##STR1## in which Ar is an aryl group and Y is a haloenol lactone moiety. The compounds of the invention are useful for the specific measurement of particular isoenzymes of glutathione S-transferase. Measurement of glutathione S-transferase isoenzymes has importance in diagnostic medicine. The compounds of the invention are also useful for treatment of drug resistance in cancer and for preventing herbicide resistance in plants.Type: GrantFiled: April 21, 1995Date of Patent: June 16, 1998Assignee: The Regents of the University of CaliforniaInventors: A. Daniel Jones, Alyson E. Mitchell, Bruce D. Hammock, Jiang Zheng
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Patent number: 5747527Abstract: Novel hypoglycemically active eremophilanolide sesquiterpenes which can be isolated from Psacalium spp., processes for obtaining the novel eremophilanolide sesquiterpenes and methods for their use as hypoglycemic agents, for example, in the treatment of diabetes are described. Further described is the use of epicacalone, cacalone, cacalol or dimaturin as hypoglycemic agents, for example, in the treatment of diabetes. In a preferred embodiment, the hypoglycemically active compounds are obtained from the roots of Psacalium decompositum. As agents for the treatment of diabetes, the hypoglycemically active compounds of the present inventions are useful for treating insulin-dependent (type I) and/or non-insulin-dependent (type II) diabetes.Type: GrantFiled: June 6, 1995Date of Patent: May 5, 1998Assignee: Shaman Pharmaceuticals, Inc.Inventors: Wayne D. Inman, Steven Row King, Joseph L. Evans, Jian Luo
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Patent number: 5734067Abstract: Providing a novel tricyclic, condensed heterocyclic compound having an anti-oxidative action and being promising for use in pharmaceutical agents, cosmetics, chemical products and the like. By chemical synthesis, a novel anti-oxidative, tricyclic, condensed heterocyclic compound represented by the following formula: ##STR1## (wherein X--Y represents CH.sub.2 --C.dbd.O, CH.sub.2 --CH.sub.2 or CH.dbd.CH; Z represents O, S, or S.dbd.O; R.sub.1 to R.sub.8 represent independently those selected from the group consisting of hydrogen atom, a hydroxyl group, a halogen group, a lower alkyl group, a lower alkoxyl group, a lower alkyl ketone group and CF.sub.3 ; and at least two of R.sub.1 to R.sub.4 are hydroxyl groups); and the salts thereof are provided. The compound has an anti-oxidative activity at the same degree as or higher than the activity of .alpha.Type: GrantFiled: March 4, 1997Date of Patent: March 31, 1998Assignee: Nippon Suisan Kaisha, Ltd.Inventors: Shuji Jinno, Yasuyo Kogure, Hiroyuki Onuki, Takaaki Okita
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Patent number: 5723633Abstract: A pyran derivative has a structure ofR.sup.2 R.sup.3 C.dbd.(C.sub.5 H.sub.2 R.sup.1 O)--(CH.dbd.CH).sub.n --C.sub.6 H.sub.2 R.sup.6 R.sup.7 --NR.sup.4 R.sup.5wherein n is 3 or 4; R.sup.1 is a proton, alkyl or phenyl group; each of R.sup.2 and R.sup.3 is independently a cyano, alkoxycarbonyl having an alkyl, acyl having an alkyl, aracyl having phenyl, sulfonyl, aryl, or aryloxy; each of R.sup.4 and R.sup.5 is an alkyl group; and each of R.sup.6 and R.sup.7 is a proton, provided that R.sup.4 and R.sup.5 are alkyl groups, and a pair of R.sup.4 and R.sup.6 as well as a pair of R.sup.5 and R.sup.7 can be bonded to each other to form a heterocycle.A photosensitive composition comprises a polymerizable compound, a polymerization initiator and a photosensitizer which is the pyran derivative. A photosensitive resin composition comprises a crosslinkable polymer, a crosslinking agent and the photosensitizer.Type: GrantFiled: December 20, 1995Date of Patent: March 3, 1998Assignee: Canon Kabushiki KaishaInventors: Shin Kobayashi, Susumu Matsumura, Naosato Taniguchi, Yoko Yoshinaga, Toshiyuki Sudo, Hideki Morishima, Tadashi Kaneko
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Patent number: 5723488Abstract: A compound of formula (I): ##STR1## wherein the broken lines represent independently optional bonds, R.sup.1 and R.sup.2 being absent when the C.sub.22 -C.sub.23 double bond is present.Type: GrantFiled: August 12, 1996Date of Patent: March 3, 1998Assignee: Pfizer Inc.Inventor: Nigel Derek Walshe
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Patent number: 5721260Abstract: The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts therefor, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.Type: GrantFiled: April 4, 1996Date of Patent: February 24, 1998Assignee: Novo Nordisk A/SInventors: Rolf Hohlweg, Knud Erik Andersen, Tine Krogh J.o slashed.rgensen, Peter Madsen, Henrik Sune Andersen
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Patent number: 5719297Abstract: A vitamin D.sub.3 derivative represented by the following formula: ##STR1## wherein, R is, independently, a hydrogen atom, tri(C.sub.1 to C.sub.7 hydrocarbon)silyl group, C.sub.2 to C.sub.8 acyl group, or group forming an acetal bond together with an oxygen atom of a hydroxyl group, A is ##STR2## where, R.sup.1 is a methyl group or methylene group, and when R.sup.1 is a methylene group, the bond between the R.sup.1 and the 3-position of the lactone ring is a double bond, R.sup.2 is a hydrogen atom or C.sub.1 to C.sub.3 alkyl group, R.sup.3 is a hydrogen atom, or R.sup.2 and R.sup.3 together indicate a substitutable single methylene group.Type: GrantFiled: February 6, 1996Date of Patent: February 17, 1998Assignee: Teijin LimitedInventors: Masayasu Tabe, Atsuo Hazato, Kenji Manabe, Qingzhi Gao, Hiroko Tanaka
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Patent number: 5719299Abstract: A process for the catalytic vapor-phase oxidation of ethylene with a molecular oxygen-containing gas, in a reactor comprising a multitude of reaction tubes containing a supported silver catalyst and surrounded by a heat-exchange fluid which enters the reactor in liquid form and leaves the reactor in vapor form, characterized in that between 5 and 100 wt % of the liquid heat-exchange fluid is introduced to the reactor at its downstream end, at a temperature which is at least 20.degree. C. below the temperature of the heat-exchange fluid on leaving the reactor.Type: GrantFiled: April 17, 1996Date of Patent: February 17, 1998Assignee: Shell Oil CompanyInventor: Arend Jan Te Raa
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Patent number: 5719310Abstract: The present invention relates to a new 3-aryl-4-hydroxy-.DELTA..sup.3 -dihydrofuranone derivatives of the general formula (I) ##STR1## in which the radicals A, B, G, X, Y, Z and n have the meaning given in the description, to a plurality of processes for their preparation, and to their use as pesticides.Type: GrantFiled: November 5, 1996Date of Patent: February 17, 1998Assignee: Bayer AktiengesellschaftInventors: Reiner Fischer, Thomas Bretschneider, Bernd-Wieland Kruger, Hans-Joachim Santel, Markus Dollinger, Ulrike Wachendorff-Neumann, Christoph Erdelen
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Patent number: 5716599Abstract: The invention involves a cosmetic preparation containing kaolin which may be employed as a mask, lotion, gel or cream with a non-sticky, non-plasticized consistency and with a content of white kaolin with a high proportion of kaolinite and spherical inorganic particles of a particle size of less than 5 .mu.m, with a proportion of spherical particles in the kaolin mixture of 0.5 to 10% by weight as well as a cosmetic skin care composition, in which the proportion of the kaolin/spherical particle mixture falls within the range of over 2 to 65% by weight of the composition as a whole. The viscosity of the composition with the proportion of kaolin/spherical particles is around 2000 to over 15,000 cps higher than a similar composition with kaolin only and without spherical particles, with the difference in viscosity increasing with the proportion of kaolin/spherical particles.Type: GrantFiled: May 9, 1997Date of Patent: February 10, 1998Assignee: Lancaster Group GmbHInventors: Karin Golz, Leonhard Zastrow, Klaus Stanzl, Alfred Braunagel