Patents Examined by Amelia Owens
  • Methods for preparing an estrogenic preparation and isolated estrogenic compounds from a plant and uses thereof
    Patent number: 6750248
    Abstract: Methods for preparing an estrogenic preparation and isolating estrogenic compounds from a plant, such as an Epimedium plant, are provided. Also provided are estrogenic compounds from Epimedium plant that have been isolated and characterized, and methods for their use in modulating estrogen receptors and in treating conditions mediated by estrogen receptors, such as menopause and estrogen-dependent cancers. Also provided are preparations from Epimedium that are enriched for estrogenic compounds, and methods for their use in modulating estrogen receptors and preventing and treating conditions that are mediated by estrogen receptors.
    Type: Grant
    Filed: November 5, 2002
    Date of Patent: June 15, 2004
    Assignee: National University of Singapore
    Inventors: Eu Leong Yong, Sook Peng Yap
  • Glucamine salts for treating hepatitis virus infections
    Patent number: 6747149
    Abstract: N-Substituted glucamine compounds of formula I are effective in treatment of hepatitis infections, including hepatitis B and hepatitis C. In treating hepatitis infections the compounds of formular I may be used alone, or in combinatioin with another antiviral agent selected from among nucleosides, nucleotides, immunomodulators, immunostimulants or various combination of such other agents.
    Type: Grant
    Filed: December 17, 2002
    Date of Patent: June 8, 2004
    Assignee: G. D. Searle & Co.
    Inventors: Richard A. Mueller, Martin L. Bryant, Richard A. Partis
  • Non-natural galanin receptor ligands
    Patent number: 6747060
    Abstract: Compounds which are non-natural galanin receptor ligands are disclosed. The ligands are of small size, have agonist or antagonist galanin activity and may cross the blood-brain barrier to displace galanin from galanin receptors. The ligands are useful as medicaments for treatment of convulsions (e.g. in epilepsy), diseases and disorders related to endocrinology (e.g., growth hormone, insulin or prolactin release), tumors expressing galanin receptors, feeding disorders pain, allodynia, psychiatric disorders such as depression (involving e.g., noradrenaline or serotonin), cognitive disorders (e.g. Alzeimer's disease), and the like.
    Type: Grant
    Filed: May 24, 2002
    Date of Patent: June 8, 2004
    Assignee: Kemia, Inc.
    Inventors: Kulliki Saar, Tamas Bartfai, Ulo Langel, Gerd Hallnemo, Sven Hellberg
  • BIS hydrochloride monohydrate salt of RSV fusion inhibitor
    Patent number: 6737428
    Abstract: The novel crystalline bis hydrochloride monohydrate salt having the formula and pharmaceutical dosage forms thereof is provided having use in the treatment of respiratory syncytial viral infection.
    Type: Grant
    Filed: December 5, 2002
    Date of Patent: May 18, 2004
    Assignee: Bristol-Myers Squibb Company
    Inventors: Christoph Gesenberg, David Paul Provencal, Srinivasan Venkatesh, Hua Wang
  • Thin-film epoxidation of an unsaturated oil or alkyl fatty acid ester
    Patent number: 6734315
    Abstract: A method of epoxidizing an unsaturated compound having a carbon-to-carbon double bond to form an oxirane ring across the double bond comprising adding to said unsaturated compound an oxidizing agent selected from hydrogen peroxide, acetaldehyde monoperacetate, an organic hydroperoxide, or a combination thereof, to form a reactant mixture; and forming the reactant mixture in a film against a wall of the thin-film reactor that is at a temperature sufficient for reaction of the oxidizing agent with the unsaturated compound to form an oxirane ring across a double bond of the unsaturated compound.
    Type: Grant
    Filed: June 27, 2003
    Date of Patent: May 11, 2004
    Assignee: The C.P. Hall Company
    Inventors: James A. Nowak, Thomas A. Zillner, Leslie Patrick Mullin, III
  • Synthetic salicylihalamides, apicularens and derivatives thereof
    Patent number: 6734209
    Abstract: The present invention provides compounds having improved stability over that of natural benzolactones, and a process for synthesizing these compounds. These compounds exhibit anti-cancer activity and inhibit V-ATPase activity.
    Type: Grant
    Filed: April 18, 2003
    Date of Patent: May 11, 2004
    Assignee: Board of Regents The University of Texas System
    Inventors: Jef De Brabander, Yusheng Wu
  • Synthesis of spiro esters, spiro ortho carbonates, and intermediates
    Patent number: 6734313
    Abstract: Ortho esters and ortho carbonates can be produced by alkylating esters and carbonates with, for example, the hexafluorophosphate salt of a trialkyl oxonium ion. The spiro species are useful intermediates in the synthesis of complex organic molecules. Synthetic pathways for the production of medically active compounds incorporates spiro ortho esters. Anti-first-pass effect materials are produced in high yield utilizing a synthetic strategy incorporating cyclic ortho ester intermediates.
    Type: Grant
    Filed: May 9, 2003
    Date of Patent: May 11, 2004
    Assignee: Bioavailability Systems, LLC
    Inventors: Robert Seemayer, Jack Liang
  • Method for the production of tetrahydrofuran
    Patent number: 6730800
    Abstract: Unsubstituted or alkyl-substituted THF is obtained by catalytic hydrogenation in the gas phase of C4-dicarboxylic acids and/or their derivatives using a catalyst comprising <80% by weight, preferably <70% by weight, in particular from 10 to 65% by weight, of CuO and >20% by weight, preferably >30% by weight, in particular from 35 to 90% by weight, of an oxidic support having acid centers, at a hot spot temperature of from 240 to 310° C., preferably from 240 to 280° C., and a WHSV over the catalyst of from 0.01 to 1.0, preferably from 0.02 to 1, in particular from 0.05 to 0.5, kg of starting material/l of catalyst x hour.
    Type: Grant
    Filed: June 4, 2003
    Date of Patent: May 4, 2004
    Assignee: BASF Aktiengesellschaft
    Inventors: Rolf-Hartmuth Fischer, Frank Stein, Rolf Pinkos, Michael Hesse, Michael Jolyon Sprague, Markus Rösch, Holger Borchert, Stephan Schlitter, Ralf-Thomas Rahn, Alexander Weck
  • Process for the preparation of substituted octanoyl amides
    Patent number: 6730798
    Abstract: Compounds of formula (II) are simultaneously halogenated in the 5 position and hydroxylated in the 4 position under lactonization, the halolactone is converted into a hydroxylactone and then the hydroxy group into a leaving group, the leaving group is replaced with azide, the lactone amidated and then the azide converted to the amine group, in order to obtain compounds of formula (I).
    Type: Grant
    Filed: January 3, 2003
    Date of Patent: May 4, 2004
    Assignee: Speedel Pharma AG
    Inventors: Stefan Stutz, Peter Herold, Felix Spindler
  • Synthetic intermediate for epothilone derivative and production method thereof
    Patent number: 6730803
    Abstract: The &bgr;-keto ester compound, &bgr;-hydroxy acid compound and acetonide form of a 1,3-diol derivative of the formulas (I), (V) and (VIII) wherein each symbol is as defined in the specification, are useful as a synthetic intermediate for an epothilone derivative being developed as a pharmaceutical agent having an antitumor activity.
    Type: Grant
    Filed: September 30, 2002
    Date of Patent: May 4, 2004
    Assignee: Sumika Fine Chemicals Co., Ltd.
    Inventors: Mitsuhiro Iwasaki, Kiyoshi Sugi, Hideto Miyamoto, Nobushige Itaya
  • Compounds affecting cholesterol absorption
    Patent number: 6727277
    Abstract: A class of novel compounds is described for use in affecting lymphatic absorption of cholesterol. Compounds of particular interest are defined by Formula I: or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: November 12, 2002
    Date of Patent: April 27, 2004
    Assignee: Kansas State University Research Foundation
    Inventors: Duy H. Hua, Sung I. Koo, Sang K. Noh
  • Tricyclic compounds and uses thereof
    Patent number: 6723736
    Abstract: Substituted isoquinolines, isochromanones and isothiochromanones that inhibit the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and/or interleukin-6 (IL-6) and/or the enzyme cyclooxygenase-2 (COX-2) and/or interleukin-10 (IL-10). Compositions containing such compounds and methods of using such compounds for treatment and/or prevention of inflammation, inflammatory diseases, immunologic diseases and other diseases mediated by TNF-alpha, IL-6, COX-2 and/or IL-10 are also disclosed.
    Type: Grant
    Filed: October 10, 2001
    Date of Patent: April 20, 2004
    Assignee: Theracos, Inc.
    Inventors: Debendranath Dey, Partha Neogi, Ananda Sen, Somesh D. Sharma, Bishwajit Nag
  • Substituted 6H-DiBenzo[c,h]chromenes as estrogenic agents
    Patent number: 6723747
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R3, R4 R5, R6, and R7 are as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: December 11, 2002
    Date of Patent: April 20, 2004
    Assignee: Wyeth
    Inventors: Richard E. Mewshaw, Richard J. Edsall, Stephen T. Cohn, Heather A. Harris, James C. Keith, Jr., Leo M. Albert
  • Photochromic oxazine compounds and methods for their manufacture
    Patent number: 6720420
    Abstract: The present invention provides oxazine compounds having aromatic, heteroaromatic, or aliphatic substituents at the 2 position of the oxazine moiety.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: April 13, 2004
    Assignee: Johnson & Johnson Vision Care, Inc.
    Inventors: Weili Zhao, Erick M. Carreira
  • Oxindole derivatives
    Patent number: 6720332
    Abstract: Oxindole derivatives, specifically pyrrolo[3,2-f]quinoline-2-ones, which are useful as CDK4 inhibitors are described herein. The described invention also includes methods of making such oxindole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
    Type: Grant
    Filed: February 27, 2003
    Date of Patent: April 13, 2004
    Assignee: SmithKline Beecham Corporation
    Inventors: Scott Howard Dickerson, David Harold Drewry, James Andrew Linn
  • Systems and methods for generation of ascorbic acid with reduced color
    Patent number: 6716997
    Abstract: The present invention describes the synthesis of ascorbic acid with reduced color. The present invention employs palladium catalysts for the synthesis of ascorbic acid from 2-keto-gulonic acid or derivatives of 2-keto-gulonic acid. The palladium catalyst may include an inert support such as, but not limited to, carbon or barium sulfate. Unlike other palladium catalysts, the catalyst of the present invention is active under aqueous conditions suitable for ascorbic acid synthesis. Also described are systems for the conversion of 2-keto-gulonic acid or derivatives of 2-keto-gulonic acid to ascorbic acid in the presence of a solid palladium catalyst and ascorbic acid of reduced color made by the methods of the present invention.
    Type: Grant
    Filed: October 9, 2002
    Date of Patent: April 6, 2004
    Assignee: Eastman Chemical Company
    Inventor: Joseph R. Zoeller
  • Method for the preparation of citalopram
    Patent number: 6717000
    Abstract: The present invention relates to a method for the preparation of citalopram comprising reduction of a compound of formula wherein X is a cyano group or a group which can be converted to a cyano group, and if X is not a cyano group followed by conversion of X to a cyano group.
    Type: Grant
    Filed: September 9, 2002
    Date of Patent: April 6, 2004
    Assignee: H. Lundbeck A/S
    Inventor: Hans Petersen
  • Method to produce novel polyketides
    Patent number: 6710189
    Abstract: A polyketide, or an antibiotic which is obtainable from the polyketide by a method comprising treating the polyketide with a culture medium conditioned by Saccharopolyspora erythraea, selected from the group consisting of:
    Type: Grant
    Filed: June 28, 2002
    Date of Patent: March 23, 2004
    Assignees: Stanford University, Brown University
    Inventors: Chaitan Khosla, Rembert Pieper, Guanglin Luo, David E. Cane, Camilla Kao, Gary Ashley
  • Vasodilating compound and method of use
    Patent number: 6706756
    Abstract: The present invention is an isolated compound and method of inducing endothelium-dependent relaxation in blood vessels including the step of introducing isolated procyanidins having a preponderance of (−)-epicatechins to a patient wherein the procyanidins are preferably galloylated. To achieve both bioavailability and potency, it is also preferred that the number of epicatechins monomers forming each procyanidin is between two and five. More specifically, isolated epicatechin-(4-8)-epicatechin-(4-8)-epicatechin-gallate (C1-gallate) is administered to the patient.
    Type: Grant
    Filed: November 18, 2002
    Date of Patent: March 16, 2004
    Assignee: University of South Florida
    Inventor: David F. Fitzpatrick
  • Chiral derivatives of Hibiscus acid bearing lactone ring moiety, process for preparing the same and a convenient method for the large-scale isolation of Hibiscus acid
    Patent number: 6703515
    Abstract: The present invention relates to a novel chiral compound of Hibiscus acid bearing lactone moiety of formula I, Wherein: R1═R2═alkali salt of carboxylic acid or acid chloride or lower esters or the N-substituted cyclic imides. R3═hydroxyl or protected hydroxyl group and a process for preparing the same.
    Type: Grant
    Filed: September 5, 2001
    Date of Patent: March 9, 2004
    Assignee: Department of Science and Technology, Technology Bhavan
    Inventors: Ibrahim Ibnu Saud, Chitra Gopinath, Beena Thomas